node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
APLP2 | APP | ENSP00000263574 | ENSP00000284981 | amyloid beta (A4) precursor-like protein 2; May play a role in the regulation of hemostasis. The soluble form may have inhibitory properties towards coagulation factors. May interact with cellular G-protein signaling pathways. May bind to the DNA 5’-GTCACATG-3’(CDEI box). Inhibits trypsin, chymotrypsin, plasmin, factor XIA and plasma and glandular kallikrein. Modulates the Cu/Zn nitric oxide-catalyzed autodegradation of GPC1 heparan sulfate side chains in fibroblasts (By similarity) | amyloid beta (A4) precursor protein | 0.595 |
APLP2 | KIF5A | ENSP00000263574 | ENSP00000408979 | amyloid beta (A4) precursor-like protein 2; May play a role in the regulation of hemostasis. The soluble form may have inhibitory properties towards coagulation factors. May interact with cellular G-protein signaling pathways. May bind to the DNA 5’-GTCACATG-3’(CDEI box). Inhibits trypsin, chymotrypsin, plasmin, factor XIA and plasma and glandular kallikrein. Modulates the Cu/Zn nitric oxide-catalyzed autodegradation of GPC1 heparan sulfate side chains in fibroblasts (By similarity) | kinesin family member 5A; Microtubule-dependent motor required for slow axonal transport of neurofilament proteins (NFH, NFM and NFL) (By similarity) | 0.528 |
APLP2 | KIF5B | ENSP00000263574 | ENSP00000307078 | amyloid beta (A4) precursor-like protein 2; May play a role in the regulation of hemostasis. The soluble form may have inhibitory properties towards coagulation factors. May interact with cellular G-protein signaling pathways. May bind to the DNA 5’-GTCACATG-3’(CDEI box). Inhibits trypsin, chymotrypsin, plasmin, factor XIA and plasma and glandular kallikrein. Modulates the Cu/Zn nitric oxide-catalyzed autodegradation of GPC1 heparan sulfate side chains in fibroblasts (By similarity) | kinesin family member 5B; Microtubule-dependent motor required for normal distribution of mitochondria and lysosomes (By similarity) | 0.532 |
APLP2 | KLC3 | ENSP00000263574 | ENSP00000375810 | amyloid beta (A4) precursor-like protein 2; May play a role in the regulation of hemostasis. The soluble form may have inhibitory properties towards coagulation factors. May interact with cellular G-protein signaling pathways. May bind to the DNA 5’-GTCACATG-3’(CDEI box). Inhibits trypsin, chymotrypsin, plasmin, factor XIA and plasma and glandular kallikrein. Modulates the Cu/Zn nitric oxide-catalyzed autodegradation of GPC1 heparan sulfate side chains in fibroblasts (By similarity) | kinesin light chain 3; Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport | 0.670 |
APLP2 | MAPK8IP1 | ENSP00000263574 | ENSP00000241014 | amyloid beta (A4) precursor-like protein 2; May play a role in the regulation of hemostasis. The soluble form may have inhibitory properties towards coagulation factors. May interact with cellular G-protein signaling pathways. May bind to the DNA 5’-GTCACATG-3’(CDEI box). Inhibits trypsin, chymotrypsin, plasmin, factor XIA and plasma and glandular kallikrein. Modulates the Cu/Zn nitric oxide-catalyzed autodegradation of GPC1 heparan sulfate side chains in fibroblasts (By similarity) | mitogen-activated protein kinase 8 interacting protein 1; The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. Required for JNK activation in response to excitotoxic stress. Cytoplasmic MAPK8IP1 causes inhibition of JNK- regulated activity by retaining JNK in the cytoplasm and inhibiting JNK phosphorylation of c-Jun. May also participate in ApoER2-specific reelin signaling. Directly, or indirectly, regulates GLUT2 gene expression and beta-cell fun [...] | 0.861 |
APLP2 | MAPK8IP2 | ENSP00000263574 | ENSP00000330572 | amyloid beta (A4) precursor-like protein 2; May play a role in the regulation of hemostasis. The soluble form may have inhibitory properties towards coagulation factors. May interact with cellular G-protein signaling pathways. May bind to the DNA 5’-GTCACATG-3’(CDEI box). Inhibits trypsin, chymotrypsin, plasmin, factor XIA and plasma and glandular kallikrein. Modulates the Cu/Zn nitric oxide-catalyzed autodegradation of GPC1 heparan sulfate side chains in fibroblasts (By similarity) | mitogen-activated protein kinase 8 interacting protein 2; The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. JIP2 inhibits IL1 beta-induced apoptosis in insulin-secreting cells. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins (By similarity) | 0.820 |
APP | APLP2 | ENSP00000284981 | ENSP00000263574 | amyloid beta (A4) precursor protein | amyloid beta (A4) precursor-like protein 2; May play a role in the regulation of hemostasis. The soluble form may have inhibitory properties towards coagulation factors. May interact with cellular G-protein signaling pathways. May bind to the DNA 5’-GTCACATG-3’(CDEI box). Inhibits trypsin, chymotrypsin, plasmin, factor XIA and plasma and glandular kallikrein. Modulates the Cu/Zn nitric oxide-catalyzed autodegradation of GPC1 heparan sulfate side chains in fibroblasts (By similarity) | 0.595 |
APP | KIF5A | ENSP00000284981 | ENSP00000408979 | amyloid beta (A4) precursor protein | kinesin family member 5A; Microtubule-dependent motor required for slow axonal transport of neurofilament proteins (NFH, NFM and NFL) (By similarity) | 0.609 |
APP | KIF5B | ENSP00000284981 | ENSP00000307078 | amyloid beta (A4) precursor protein | kinesin family member 5B; Microtubule-dependent motor required for normal distribution of mitochondria and lysosomes (By similarity) | 0.640 |
APP | KLC3 | ENSP00000284981 | ENSP00000375810 | amyloid beta (A4) precursor protein | kinesin light chain 3; Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport | 0.717 |
APP | MAPK8IP1 | ENSP00000284981 | ENSP00000241014 | amyloid beta (A4) precursor protein | mitogen-activated protein kinase 8 interacting protein 1; The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. Required for JNK activation in response to excitotoxic stress. Cytoplasmic MAPK8IP1 causes inhibition of JNK- regulated activity by retaining JNK in the cytoplasm and inhibiting JNK phosphorylation of c-Jun. May also participate in ApoER2-specific reelin signaling. Directly, or indirectly, regulates GLUT2 gene expression and beta-cell fun [...] | 0.998 |
APP | MAPK8IP2 | ENSP00000284981 | ENSP00000330572 | amyloid beta (A4) precursor protein | mitogen-activated protein kinase 8 interacting protein 2; The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. JIP2 inhibits IL1 beta-induced apoptosis in insulin-secreting cells. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins (By similarity) | 0.968 |
KIF5A | APLP2 | ENSP00000408979 | ENSP00000263574 | kinesin family member 5A; Microtubule-dependent motor required for slow axonal transport of neurofilament proteins (NFH, NFM and NFL) (By similarity) | amyloid beta (A4) precursor-like protein 2; May play a role in the regulation of hemostasis. The soluble form may have inhibitory properties towards coagulation factors. May interact with cellular G-protein signaling pathways. May bind to the DNA 5’-GTCACATG-3’(CDEI box). Inhibits trypsin, chymotrypsin, plasmin, factor XIA and plasma and glandular kallikrein. Modulates the Cu/Zn nitric oxide-catalyzed autodegradation of GPC1 heparan sulfate side chains in fibroblasts (By similarity) | 0.528 |
KIF5A | APP | ENSP00000408979 | ENSP00000284981 | kinesin family member 5A; Microtubule-dependent motor required for slow axonal transport of neurofilament proteins (NFH, NFM and NFL) (By similarity) | amyloid beta (A4) precursor protein | 0.609 |
KIF5A | KIF5B | ENSP00000408979 | ENSP00000307078 | kinesin family member 5A; Microtubule-dependent motor required for slow axonal transport of neurofilament proteins (NFH, NFM and NFL) (By similarity) | kinesin family member 5B; Microtubule-dependent motor required for normal distribution of mitochondria and lysosomes (By similarity) | 0.630 |
KIF5A | KLC3 | ENSP00000408979 | ENSP00000375810 | kinesin family member 5A; Microtubule-dependent motor required for slow axonal transport of neurofilament proteins (NFH, NFM and NFL) (By similarity) | kinesin light chain 3; Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport | 0.846 |
KIF5A | MAPK8IP1 | ENSP00000408979 | ENSP00000241014 | kinesin family member 5A; Microtubule-dependent motor required for slow axonal transport of neurofilament proteins (NFH, NFM and NFL) (By similarity) | mitogen-activated protein kinase 8 interacting protein 1; The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. Required for JNK activation in response to excitotoxic stress. Cytoplasmic MAPK8IP1 causes inhibition of JNK- regulated activity by retaining JNK in the cytoplasm and inhibiting JNK phosphorylation of c-Jun. May also participate in ApoER2-specific reelin signaling. Directly, or indirectly, regulates GLUT2 gene expression and beta-cell fun [...] | 0.790 |
KIF5A | MAPK8IP2 | ENSP00000408979 | ENSP00000330572 | kinesin family member 5A; Microtubule-dependent motor required for slow axonal transport of neurofilament proteins (NFH, NFM and NFL) (By similarity) | mitogen-activated protein kinase 8 interacting protein 2; The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. JIP2 inhibits IL1 beta-induced apoptosis in insulin-secreting cells. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins (By similarity) | 0.778 |
KIF5B | APLP2 | ENSP00000307078 | ENSP00000263574 | kinesin family member 5B; Microtubule-dependent motor required for normal distribution of mitochondria and lysosomes (By similarity) | amyloid beta (A4) precursor-like protein 2; May play a role in the regulation of hemostasis. The soluble form may have inhibitory properties towards coagulation factors. May interact with cellular G-protein signaling pathways. May bind to the DNA 5’-GTCACATG-3’(CDEI box). Inhibits trypsin, chymotrypsin, plasmin, factor XIA and plasma and glandular kallikrein. Modulates the Cu/Zn nitric oxide-catalyzed autodegradation of GPC1 heparan sulfate side chains in fibroblasts (By similarity) | 0.532 |
KIF5B | APP | ENSP00000307078 | ENSP00000284981 | kinesin family member 5B; Microtubule-dependent motor required for normal distribution of mitochondria and lysosomes (By similarity) | amyloid beta (A4) precursor protein | 0.640 |