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HTR1A HTR1A GPR55 GPR55 CNR1 CNR1 CNR2 CNR2 OXER1 OXER1 LPAR2 LPAR2 P2RY14 P2RY14 NMUR1 NMUR1 DRD2 DRD2 GPR18 GPR18 P2RY13 P2RY13
"GPR55" - G protein-coupled receptor 55 in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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protein of unknown 3D structure
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some 3D structure is known or predicted
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query proteins and first shell of interactors
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second shell of interactors
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Known Interactions
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Predicted Interactions
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fusion edge
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cooccurrence edge
gene co-occurrence
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textmining
coexpression edge
co-expression
homology edge
protein homology
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Score
GPR55G protein-coupled receptor 55; May be involved in hyperalgesia associated with inflammatory and neuropathic pain (By similarity). Receptor for L- alpha-lysophosphatidylinositol (LPI). LPI induces Ca(2+) release from intracellular stores via the heterotrimeric G protein GNA13 and RHOA. Putative cannabinoid receptor. May play a role in bone physiology by regulating osteoclast number and function (319 aa)    
Predicted Functional Partners:
CNR1
cannabinoid receptor 1 (brain) (472 aa)
           score_image score_image   0.967
CNR2
cannabinoid receptor 2 (macrophage); Heterotrimeric G protein-coupled receptor for endocannabinoid 2-arachidonoylglycerol mediating inhibition of adenylate cyclase. May function in inflammatory response, nociceptive transmission and bone homeostasis (360 aa)
           score_image score_image   0.921
GPR18
G protein-coupled receptor 18; Receptor for N-arachidonyl glycine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. May contribute to regulation of the immune system (331 aa)
           score_image score_image score_image 0.917
HTR1A
5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled; This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity (422 aa)
           score_image score_image   0.912
NMUR1
neuromedin U receptor 1; Receptor for the neuromedin-U and neuromedin-S neuropeptides (By similarity) (426 aa)
           score_image score_image   0.912
OXER1
oxoeicosanoid (OXE) receptor 1; Receptor for eicosanoids and polyunsaturated fatty acids such as 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-OXO-ETE), 5(S)-hydroperoxy-6E,8Z,11Z,14Z-eicosatetraenoic acid (5(S)-HPETE) and arachidonic acid. Seems to be coupled to the G(i)/G(o), families of heteromeric G proteins (423 aa)
           score_image score_image   0.907
DRD2
dopamine receptor D2; Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase (By similarity) (443 aa)
           score_image score_image   0.906
LPAR2
lysophosphatidic acid receptor 2; Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Seems to be coupled to the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins. Plays a key role in phospholipase C-beta (PLC-beta) signaling pathway. Stimulates phospholipase C (PLC) activity in a manner that is independent of RALA activation (351 aa)
           score_image score_image   0.906
P2RY14
purinergic receptor P2Y, G-protein coupled, 14; Receptor for UDP-glucose and other UDP-sugar coupled to G-proteins. Not activated by ATP, ADP, UTP or ATP (338 aa)
           score_image score_image score_image 0.904
P2RY13
purinergic receptor P2Y, G-protein coupled, 13; Receptor for ADP. Coupled to G(i)-proteins. May play a role in hematopoiesis and the immune system (354 aa)
           score_image score_image score_image 0.903
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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