node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ARID3A | PML | ENSP00000263620 | ENSP00000268058 | AT rich interactive domain 3A (BRIGHT-like); Transcription factor which may be involved in the control of cell cycle progression by the RB1/E2F1 pathway and in B-cell differentiation | promyelocytic leukemia | 0.619 |
ARID3A | SP140 | ENSP00000263620 | ENSP00000375899 | AT rich interactive domain 3A (BRIGHT-like); Transcription factor which may be involved in the control of cell cycle progression by the RB1/E2F1 pathway and in B-cell differentiation | SP140 nuclear body protein; Component of the nuclear body, also known as nuclear domain 10, PML oncogenic domain, and KR body. May be involved in the pathogenesis of acute promyelocytic leukemia and viral infection | 0.836 |
ARID3A | SUMO1 | ENSP00000263620 | ENSP00000376076 | AT rich interactive domain 3A (BRIGHT-like); Transcription factor which may be involved in the control of cell cycle progression by the RB1/E2F1 pathway and in B-cell differentiation | SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae); Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by E3 ligases such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. [...] | 0.617 |
CBX5 | SP140 | ENSP00000209875 | ENSP00000375899 | chromobox homolog 5; Component of heterochromatin that recognizes and binds histone H3 tails methylated at ’Lys-9’ (H3K9me), leading to epigenetic repression. In contrast, it is excluded from chromatin when ’Tyr-41’ of histone H3 is phosphorylated (H3Y41ph). Can interact with lamin-B receptor (LBR). This interaction can contribute to the association of the heterochromatin with the inner nuclear membrane. Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins | SP140 nuclear body protein; Component of the nuclear body, also known as nuclear domain 10, PML oncogenic domain, and KR body. May be involved in the pathogenesis of acute promyelocytic leukemia and viral infection | 0.516 |
DAXX | ETS2 | ENSP00000266000 | ENSP00000353344 | death-domain associated protein | v-ets erythroblastosis virus E26 oncogene homolog 2 (avian); Transcription factor activating transcription. Binds specifically the DNA GGAA/T core motif (Ets-binding site or EBS) in gene promoters and stimulates transcription | 0.596 |
DAXX | PML | ENSP00000266000 | ENSP00000268058 | death-domain associated protein | promyelocytic leukemia | 0.882 |
DAXX | SP140 | ENSP00000266000 | ENSP00000375899 | death-domain associated protein | SP140 nuclear body protein; Component of the nuclear body, also known as nuclear domain 10, PML oncogenic domain, and KR body. May be involved in the pathogenesis of acute promyelocytic leukemia and viral infection | 0.522 |
DAXX | SUMO1 | ENSP00000266000 | ENSP00000376076 | death-domain associated protein | SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae); Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by E3 ligases such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. [...] | 0.972 |
ETS2 | DAXX | ENSP00000353344 | ENSP00000266000 | v-ets erythroblastosis virus E26 oncogene homolog 2 (avian); Transcription factor activating transcription. Binds specifically the DNA GGAA/T core motif (Ets-binding site or EBS) in gene promoters and stimulates transcription | death-domain associated protein | 0.596 |
ETS2 | SP140 | ENSP00000353344 | ENSP00000375899 | v-ets erythroblastosis virus E26 oncogene homolog 2 (avian); Transcription factor activating transcription. Binds specifically the DNA GGAA/T core motif (Ets-binding site or EBS) in gene promoters and stimulates transcription | SP140 nuclear body protein; Component of the nuclear body, also known as nuclear domain 10, PML oncogenic domain, and KR body. May be involved in the pathogenesis of acute promyelocytic leukemia and viral infection | 0.724 |
HMGB1 | SP140 | ENSP00000343040 | ENSP00000375899 | high mobility group box 1; DNA binding proteins that associates with chromatin and has the ability to bend DNA. Binds preferentially single-stranded DNA. Involved in V(D)J recombination by acting as a cofactor of the RAG complex. Acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS). Heparin-binding protein that has a role in the extension of neurite-type cytoplasmic processes in developing cells (By similarity) | SP140 nuclear body protein; Component of the nuclear body, also known as nuclear domain 10, PML oncogenic domain, and KR body. May be involved in the pathogenesis of acute promyelocytic leukemia and viral infection | 0.606 |
PIN1 | PML | ENSP00000247970 | ENSP00000268058 | peptidylprolyl cis/trans isomerase, NIMA-interacting 1; Essential PPIase that regulates mitosis presumably by interacting with NIMA and attenuating its mitosis-promoting activity. Displays a preference for an acidic residue N-terminal to the isomerized proline bond. Catalyzes pSer/Thr-Pro cis/trans isomerizations. Down-regulates kinase activity of BTK. Can transactivate multiple oncogenes and induce centrosome amplification, chromosome instability and cell transformation. Required for the efficient dephosphorylation and recycling of RAF1 after mitogen activation. Binds and targets PML [...] | promyelocytic leukemia | 0.964 |
PIN1 | SP140 | ENSP00000247970 | ENSP00000375899 | peptidylprolyl cis/trans isomerase, NIMA-interacting 1; Essential PPIase that regulates mitosis presumably by interacting with NIMA and attenuating its mitosis-promoting activity. Displays a preference for an acidic residue N-terminal to the isomerized proline bond. Catalyzes pSer/Thr-Pro cis/trans isomerizations. Down-regulates kinase activity of BTK. Can transactivate multiple oncogenes and induce centrosome amplification, chromosome instability and cell transformation. Required for the efficient dephosphorylation and recycling of RAF1 after mitogen activation. Binds and targets PML [...] | SP140 nuclear body protein; Component of the nuclear body, also known as nuclear domain 10, PML oncogenic domain, and KR body. May be involved in the pathogenesis of acute promyelocytic leukemia and viral infection | 0.576 |
PML | ARID3A | ENSP00000268058 | ENSP00000263620 | promyelocytic leukemia | AT rich interactive domain 3A (BRIGHT-like); Transcription factor which may be involved in the control of cell cycle progression by the RB1/E2F1 pathway and in B-cell differentiation | 0.619 |
PML | DAXX | ENSP00000268058 | ENSP00000266000 | promyelocytic leukemia | death-domain associated protein | 0.882 |
PML | PIN1 | ENSP00000268058 | ENSP00000247970 | promyelocytic leukemia | peptidylprolyl cis/trans isomerase, NIMA-interacting 1; Essential PPIase that regulates mitosis presumably by interacting with NIMA and attenuating its mitosis-promoting activity. Displays a preference for an acidic residue N-terminal to the isomerized proline bond. Catalyzes pSer/Thr-Pro cis/trans isomerizations. Down-regulates kinase activity of BTK. Can transactivate multiple oncogenes and induce centrosome amplification, chromosome instability and cell transformation. Required for the efficient dephosphorylation and recycling of RAF1 after mitogen activation. Binds and targets PML [...] | 0.964 |
PML | SP140 | ENSP00000268058 | ENSP00000375899 | promyelocytic leukemia | SP140 nuclear body protein; Component of the nuclear body, also known as nuclear domain 10, PML oncogenic domain, and KR body. May be involved in the pathogenesis of acute promyelocytic leukemia and viral infection | 0.472 |
PML | SUMO1 | ENSP00000268058 | ENSP00000376076 | promyelocytic leukemia | SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae); Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by E3 ligases such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. [...] | 0.999 |
SERPINA4 | SP140 | ENSP00000298841 | ENSP00000375899 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 4; Inhibits human amidolytic and kininogenase activities of tissue kallikrein. Inhibition is achieved by formation of an equimolar, heat- and SDS-stable complex between the inhibitor and the enzyme, and generation of a small C-terminal fragment of the inhibitor due to cleavage at the reactive site by tissue kallikrein | SP140 nuclear body protein; Component of the nuclear body, also known as nuclear domain 10, PML oncogenic domain, and KR body. May be involved in the pathogenesis of acute promyelocytic leukemia and viral infection | 0.518 |
SIRT2 | SP140 | ENSP00000249396 | ENSP00000375899 | sirtuin 2; NAD-dependent protein deacetylase, which deacetylates internal lysines on histone and non-histone proteins. Deacetylates ’Lys-40’ of alpha-tubulin. Involved in the control of mitotic exit in the cell cycle, probably via its role in the regulation of cytoskeleton. Deacetylates PCK1, opposing proteasomal degradation. Deacetylates ’Lys-310’ of RELA | SP140 nuclear body protein; Component of the nuclear body, also known as nuclear domain 10, PML oncogenic domain, and KR body. May be involved in the pathogenesis of acute promyelocytic leukemia and viral infection | 0.585 |