node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ADHFE1 | ARMC6 | ENSP00000379865 | ENSP00000376148 | alcohol dehydrogenase, iron containing, 1; Catalyzes the cofactor-independent reversible oxidation of gamma-hydroxybutyrate (GHB) to succinic semialdehyde (SSA) coupled to reduction of 2-ketoglutarate (2-KG) to D-2- hydroxyglutarate (D-2-HG). D,L-3-hydroxyisobutyrate and L-3- hydroxybutyrate (L-3-OHB) are also substrates for HOT with 10-fold lower activities | armadillo repeat containing 6 | 0.621 |
ADHFE1 | QPCTL | ENSP00000379865 | ENSP00000012049 | alcohol dehydrogenase, iron containing, 1; Catalyzes the cofactor-independent reversible oxidation of gamma-hydroxybutyrate (GHB) to succinic semialdehyde (SSA) coupled to reduction of 2-ketoglutarate (2-KG) to D-2- hydroxyglutarate (D-2-HG). D,L-3-hydroxyisobutyrate and L-3- hydroxybutyrate (L-3-OHB) are also substrates for HOT with 10-fold lower activities | glutaminyl-peptide cyclotransferase-like; Responsible for the biosynthesis of pyroglutamyl peptides | 0.500 |
ADHFE1 | SYTL3 | ENSP00000379865 | ENSP00000297239 | alcohol dehydrogenase, iron containing, 1; Catalyzes the cofactor-independent reversible oxidation of gamma-hydroxybutyrate (GHB) to succinic semialdehyde (SSA) coupled to reduction of 2-ketoglutarate (2-KG) to D-2- hydroxyglutarate (D-2-HG). D,L-3-hydroxyisobutyrate and L-3- hydroxybutyrate (L-3-OHB) are also substrates for HOT with 10-fold lower activities | synaptotagmin-like 3; May act as Rab effector protein and play a role in vesicle trafficking. Binds phospholipids in the presence of calcium ions (By similarity) | 0.489 |
ADHFE1 | WDR6 | ENSP00000379865 | ENSP00000378857 | alcohol dehydrogenase, iron containing, 1; Catalyzes the cofactor-independent reversible oxidation of gamma-hydroxybutyrate (GHB) to succinic semialdehyde (SSA) coupled to reduction of 2-ketoglutarate (2-KG) to D-2- hydroxyglutarate (D-2-HG). D,L-3-hydroxyisobutyrate and L-3- hydroxybutyrate (L-3-OHB) are also substrates for HOT with 10-fold lower activities | WD repeat domain 6; Enhances the STK11/LKB1-induced cell growth suppression activity. Negative regulator of amino acid starvation-induced autophagy | 0.490 |
ADHFE1 | ZADH2 | ENSP00000379865 | ENSP00000323678 | alcohol dehydrogenase, iron containing, 1; Catalyzes the cofactor-independent reversible oxidation of gamma-hydroxybutyrate (GHB) to succinic semialdehyde (SSA) coupled to reduction of 2-ketoglutarate (2-KG) to D-2- hydroxyglutarate (D-2-HG). D,L-3-hydroxyisobutyrate and L-3- hydroxybutyrate (L-3-OHB) are also substrates for HOT with 10-fold lower activities | zinc binding alcohol dehydrogenase domain containing 2 | 0.511 |
ARMC6 | ADHFE1 | ENSP00000376148 | ENSP00000379865 | armadillo repeat containing 6 | alcohol dehydrogenase, iron containing, 1; Catalyzes the cofactor-independent reversible oxidation of gamma-hydroxybutyrate (GHB) to succinic semialdehyde (SSA) coupled to reduction of 2-ketoglutarate (2-KG) to D-2- hydroxyglutarate (D-2-HG). D,L-3-hydroxyisobutyrate and L-3- hydroxybutyrate (L-3-OHB) are also substrates for HOT with 10-fold lower activities | 0.621 |
ARMC6 | FAM82B | ENSP00000376148 | ENSP00000385927 | armadillo repeat containing 6 | family with sequence similarity 82, member B | 0.485 |
ARMC6 | KBTBD10 | ENSP00000376148 | ENSP00000284669 | armadillo repeat containing 6 | kelch repeat and BTB (POZ) domain containing 10; Involved in skeletal muscle development and differentiation. Regulates proliferation and differentiation of myoblasts and plays a role in myofibril assembly by promoting lateral fusion of adjacent thin fibrils into mature, wide myofibrils. Required for pseudopod elongation in transformed cells (By similarity) | 0.562 |
ARMC6 | QPCTL | ENSP00000376148 | ENSP00000012049 | armadillo repeat containing 6 | glutaminyl-peptide cyclotransferase-like; Responsible for the biosynthesis of pyroglutamyl peptides | 0.579 |
ARMC6 | STK36 | ENSP00000376148 | ENSP00000295709 | armadillo repeat containing 6 | serine/threonine kinase 36; Serine/threonine protein kinase which plays an important role in the sonic hedgehog (Shh) pathway by regulating the activity of GLI transcription factors. Controls the activity of the transcriptional regulators GLI1, GLI2 and GLI3 by opposing the effect of SUFU and promoting their nuclear localization. GLI2 requires an additional function of STK36 to become transcriptionally active, but the enzyme does not need to possess an active kinase catalytic site for this to occur. Required for postnatal development, possibly by regulating the homeostasis of cerebral [...] | 0.482 |
ARMC6 | SYTL3 | ENSP00000376148 | ENSP00000297239 | armadillo repeat containing 6 | synaptotagmin-like 3; May act as Rab effector protein and play a role in vesicle trafficking. Binds phospholipids in the presence of calcium ions (By similarity) | 0.636 |
ARMC6 | UBC | ENSP00000376148 | ENSP00000344818 | armadillo repeat containing 6 | ubiquitin C | 0.970 |
ARMC6 | WDR6 | ENSP00000376148 | ENSP00000378857 | armadillo repeat containing 6 | WD repeat domain 6; Enhances the STK11/LKB1-induced cell growth suppression activity. Negative regulator of amino acid starvation-induced autophagy | 0.632 |
ARMC6 | ZADH2 | ENSP00000376148 | ENSP00000323678 | armadillo repeat containing 6 | zinc binding alcohol dehydrogenase domain containing 2 | 0.520 |
ARMC6 | ZMIZ1 | ENSP00000376148 | ENSP00000334474 | armadillo repeat containing 6 | zinc finger, MIZ-type containing 1; Increases ligand-dependent transcriptional activity of AR and promotes AR sumoylation. The stimulation of AR activity is dependent upon sumoylation | 0.533 |
FAM82B | ARMC6 | ENSP00000385927 | ENSP00000376148 | family with sequence similarity 82, member B | armadillo repeat containing 6 | 0.485 |
FAM82B | UBC | ENSP00000385927 | ENSP00000344818 | family with sequence similarity 82, member B | ubiquitin C | 0.620 |
KBTBD10 | ARMC6 | ENSP00000284669 | ENSP00000376148 | kelch repeat and BTB (POZ) domain containing 10; Involved in skeletal muscle development and differentiation. Regulates proliferation and differentiation of myoblasts and plays a role in myofibril assembly by promoting lateral fusion of adjacent thin fibrils into mature, wide myofibrils. Required for pseudopod elongation in transformed cells (By similarity) | armadillo repeat containing 6 | 0.562 |
KBTBD10 | SYTL3 | ENSP00000284669 | ENSP00000297239 | kelch repeat and BTB (POZ) domain containing 10; Involved in skeletal muscle development and differentiation. Regulates proliferation and differentiation of myoblasts and plays a role in myofibril assembly by promoting lateral fusion of adjacent thin fibrils into mature, wide myofibrils. Required for pseudopod elongation in transformed cells (By similarity) | synaptotagmin-like 3; May act as Rab effector protein and play a role in vesicle trafficking. Binds phospholipids in the presence of calcium ions (By similarity) | 0.419 |
KBTBD10 | UBC | ENSP00000284669 | ENSP00000344818 | kelch repeat and BTB (POZ) domain containing 10; Involved in skeletal muscle development and differentiation. Regulates proliferation and differentiation of myoblasts and plays a role in myofibril assembly by promoting lateral fusion of adjacent thin fibrils into mature, wide myofibrils. Required for pseudopod elongation in transformed cells (By similarity) | ubiquitin C | 0.699 |