node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CHRDL2 | CRLF1 | ENSP00000263671 | ENSP00000376188 | chordin-like 2; May inhibit BMPs activity by blocking their interaction with their receptors. Has a negative regulator effect on the cartilage formation/regeneration from immature mesenchymal cells, by preventing or reducing the rate of matrix accumulation (By similarity). Implicated in tumor angiogenesis. May play a role during myoblast and osteoblast differentiation, and maturation | cytokine receptor-like factor 1; Cytokine receptor subunit, possibly playing a regulatory role in the immune system and during fetal development. May be involved in nervous system development | 0.468 |
CLCF1 | CNTF | ENSP00000309338 | ENSP00000355370 | cardiotrophin-like cytokine factor 1; Cytokine with B-cell stimulating capability. Binds to and activates the ILST/gp130 receptor | ciliary neurotrophic factor; CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy | 0.923 |
CLCF1 | CNTFR | ENSP00000309338 | ENSP00000242338 | cardiotrophin-like cytokine factor 1; Cytokine with B-cell stimulating capability. Binds to and activates the ILST/gp130 receptor | ciliary neurotrophic factor receptor; Binds to CNTF. The alpha subunit provides the receptor specificity | 0.987 |
CLCF1 | CRLF1 | ENSP00000309338 | ENSP00000376188 | cardiotrophin-like cytokine factor 1; Cytokine with B-cell stimulating capability. Binds to and activates the ILST/gp130 receptor | cytokine receptor-like factor 1; Cytokine receptor subunit, possibly playing a regulatory role in the immune system and during fetal development. May be involved in nervous system development | 0.986 |
CNTF | CLCF1 | ENSP00000355370 | ENSP00000309338 | ciliary neurotrophic factor; CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy | cardiotrophin-like cytokine factor 1; Cytokine with B-cell stimulating capability. Binds to and activates the ILST/gp130 receptor | 0.923 |
CNTF | CNTFR | ENSP00000355370 | ENSP00000242338 | ciliary neurotrophic factor; CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy | ciliary neurotrophic factor receptor; Binds to CNTF. The alpha subunit provides the receptor specificity | 0.999 |
CNTF | CRLF1 | ENSP00000355370 | ENSP00000376188 | ciliary neurotrophic factor; CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy | cytokine receptor-like factor 1; Cytokine receptor subunit, possibly playing a regulatory role in the immune system and during fetal development. May be involved in nervous system development | 0.487 |
CNTFR | CLCF1 | ENSP00000242338 | ENSP00000309338 | ciliary neurotrophic factor receptor; Binds to CNTF. The alpha subunit provides the receptor specificity | cardiotrophin-like cytokine factor 1; Cytokine with B-cell stimulating capability. Binds to and activates the ILST/gp130 receptor | 0.987 |
CNTFR | CNTF | ENSP00000242338 | ENSP00000355370 | ciliary neurotrophic factor receptor; Binds to CNTF. The alpha subunit provides the receptor specificity | ciliary neurotrophic factor; CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy | 0.999 |
CNTFR | CRLF1 | ENSP00000242338 | ENSP00000376188 | ciliary neurotrophic factor receptor; Binds to CNTF. The alpha subunit provides the receptor specificity | cytokine receptor-like factor 1; Cytokine receptor subunit, possibly playing a regulatory role in the immune system and during fetal development. May be involved in nervous system development | 0.686 |
CNTFR | IL24 | ENSP00000242338 | ENSP00000375795 | ciliary neurotrophic factor receptor; Binds to CNTF. The alpha subunit provides the receptor specificity | interleukin 24; Has antiproliferative properties on melanoma cells and may contribute to terminal cell differentiation | 0.800 |
CRLF1 | CHRDL2 | ENSP00000376188 | ENSP00000263671 | cytokine receptor-like factor 1; Cytokine receptor subunit, possibly playing a regulatory role in the immune system and during fetal development. May be involved in nervous system development | chordin-like 2; May inhibit BMPs activity by blocking their interaction with their receptors. Has a negative regulator effect on the cartilage formation/regeneration from immature mesenchymal cells, by preventing or reducing the rate of matrix accumulation (By similarity). Implicated in tumor angiogenesis. May play a role during myoblast and osteoblast differentiation, and maturation | 0.468 |
CRLF1 | CLCF1 | ENSP00000376188 | ENSP00000309338 | cytokine receptor-like factor 1; Cytokine receptor subunit, possibly playing a regulatory role in the immune system and during fetal development. May be involved in nervous system development | cardiotrophin-like cytokine factor 1; Cytokine with B-cell stimulating capability. Binds to and activates the ILST/gp130 receptor | 0.986 |
CRLF1 | CNTF | ENSP00000376188 | ENSP00000355370 | cytokine receptor-like factor 1; Cytokine receptor subunit, possibly playing a regulatory role in the immune system and during fetal development. May be involved in nervous system development | ciliary neurotrophic factor; CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy | 0.487 |
CRLF1 | CNTFR | ENSP00000376188 | ENSP00000242338 | cytokine receptor-like factor 1; Cytokine receptor subunit, possibly playing a regulatory role in the immune system and during fetal development. May be involved in nervous system development | ciliary neurotrophic factor receptor; Binds to CNTF. The alpha subunit provides the receptor specificity | 0.686 |
CRLF1 | FAM155B | ENSP00000376188 | ENSP00000252338 | cytokine receptor-like factor 1; Cytokine receptor subunit, possibly playing a regulatory role in the immune system and during fetal development. May be involved in nervous system development | family with sequence similarity 155, member B | 0.416 |
CRLF1 | IL24 | ENSP00000376188 | ENSP00000375795 | cytokine receptor-like factor 1; Cytokine receptor subunit, possibly playing a regulatory role in the immune system and during fetal development. May be involved in nervous system development | interleukin 24; Has antiproliferative properties on melanoma cells and may contribute to terminal cell differentiation | 0.453 |
CRLF1 | MYH3 | ENSP00000376188 | ENSP00000226209 | cytokine receptor-like factor 1; Cytokine receptor subunit, possibly playing a regulatory role in the immune system and during fetal development. May be involved in nervous system development | myosin, heavy chain 3, skeletal muscle, embryonic; Muscle contraction | 0.608 |
CRLF1 | PRSS46 | ENSP00000376188 | ENSP00000430307 | cytokine receptor-like factor 1; Cytokine receptor subunit, possibly playing a regulatory role in the immune system and during fetal development. May be involved in nervous system development | protease, serine, 46 | 0.419 |
CRLF1 | RRAS2 | ENSP00000376188 | ENSP00000256196 | cytokine receptor-like factor 1; Cytokine receptor subunit, possibly playing a regulatory role in the immune system and during fetal development. May be involved in nervous system development | related RAS viral (r-ras) oncogene homolog 2; It is a plasma membrane-associated GTP-binding protein with GTPase activity. Might transduce growth inhibitory signals across the cell membrane, exerting its effect through an effector shared with the Ras proteins but in an antagonistic fashion | 0.517 |