CCDC50 protein (Homo sapiens) - STRING network view

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CCDC50

coiled-coil domain containing 50; Involved in EGFR signaling (482 aa)

Predicted Functional Partners:

UBC

0.998

EGFR

0.916

RIPK1

0.811

COIL

0.660

OTUD7B

0.596

TNFAIP3

0.576

SH3RF2

0.575

UBB

0.574

CRIPT

0.564

FGF12

0.564

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CCDC50	COIL	ENSP00000376250	ENSP00000240316	coiled-coil domain containing 50; Involved in EGFR signaling	coilin; Is a component of the nuclear coiled bodies (CBS) which are involved in the function or assembly/disassembly of nucleoplasmic snRNPs. During mitosis, CBS disassemble, coinciding with a mitotic-specific phosphorylation of p80 coilin	0.660
CCDC50	CRIPT	ENSP00000376250	ENSP00000238892	coiled-coil domain containing 50; Involved in EGFR signaling	cysteine-rich PDZ-binding protein; Involved in the cytoskeletal anchoring of DLG4 in excitatory synapses (By similarity)	0.564
CCDC50	EGFR	ENSP00000376250	ENSP00000275493	coiled-coil domain containing 50; Involved in EGFR signaling	epidermal growth factor receptor	0.916
CCDC50	FGF12	ENSP00000376250	ENSP00000413496	coiled-coil domain containing 50; Involved in EGFR signaling	fibroblast growth factor 12; Probably involved in nervous system development and function	0.564
CCDC50	OTUD7B	ENSP00000376250	ENSP00000358131	coiled-coil domain containing 50; Involved in EGFR signaling	OTU domain containing 7B; Negative regulator of the non-canonical NF-kappa-B pathway that acts by mediating deubiquitination of TRAF3, an inhibitor of the NF-kappa-B pathway, thereby acting as a negative regulator of B-cell responses. In response to non-canonical NF- kappa-B stimuli, deubiquitinates ’Lys-48’-linked polyubiquitin chains of TRAF3, preventing TRAF3 proteolysis and over-activation of non-canonical NF-kappa-B. Negatively regulates mucosal immunity against infections. Mediates deubiquitination of EGFR. Has deubiquitinating activity toward ’Lys-11’, ’Lys-48’ or ’Lys-63’- link [...]	0.596
CCDC50	RIPK1	ENSP00000376250	ENSP00000259808	coiled-coil domain containing 50; Involved in EGFR signaling	receptor (TNFRSF)-interacting serine-threonine kinase 1; Serine-threonine kinase which transduces inflammatory and cell-death signals (programmed necrosis) following death receptors ligation, activation of pathogen recognition receptors (PRRs), and DNA damage. Upon activation of TNFR1 by the TNF-alpha family cytokines, TRADD and TRAF2 are recruited to the receptor. Phosphorylates DAB2IP at ’Ser-728’ in a TNF-alpha-dependent manner, and thereby activates the MAP3K5-JNK apoptotic cascade. Ubiquitination by TRAF2 via ’Lys-63’-link chains acts as a critical enhancer of communication with d [...]	0.811
CCDC50	SH3RF2	ENSP00000376250	ENSP00000352028	coiled-coil domain containing 50; Involved in EGFR signaling	SH3 domain containing ring finger 2; Inhibits PPP1CA phosphatase activity. May be a E3 ubiquitin-protein ligase (Potential). May play a role in cardiac function	0.575
CCDC50	TNFAIP3	ENSP00000376250	ENSP00000237289	coiled-coil domain containing 50; Involved in EGFR signaling	tumor necrosis factor, alpha-induced protein 3; Ubiquitin-editing enzyme that contains both ubiquitin ligase and deubiquitinase activities. Involved in immune and inflammatory responses signaled by cytokines, such as TNF-alpha and IL-1 beta, or pathogens via Toll-like receptors (TLRs) through terminating NF-kappa-B activity. Essential component of a ubiquitin-editing protein complex, comprising also RNF11, ITCH and TAX1BP1, that ensures the transient nature of inflammatory signaling pathways. In cooperation with TAX1BP1 promotes disassembly of E2-E3 ubiquitin protein ligase complexes i [...]	0.576
CCDC50	UBB	ENSP00000376250	ENSP00000304697	coiled-coil domain containing 50; Involved in EGFR signaling	ubiquitin B	0.574
CCDC50	UBC	ENSP00000376250	ENSP00000344818	coiled-coil domain containing 50; Involved in EGFR signaling	ubiquitin C	0.998
COIL	CCDC50	ENSP00000240316	ENSP00000376250	coilin; Is a component of the nuclear coiled bodies (CBS) which are involved in the function or assembly/disassembly of nucleoplasmic snRNPs. During mitosis, CBS disassemble, coinciding with a mitotic-specific phosphorylation of p80 coilin	coiled-coil domain containing 50; Involved in EGFR signaling	0.660
COIL	UBC	ENSP00000240316	ENSP00000344818	coilin; Is a component of the nuclear coiled bodies (CBS) which are involved in the function or assembly/disassembly of nucleoplasmic snRNPs. During mitosis, CBS disassemble, coinciding with a mitotic-specific phosphorylation of p80 coilin	ubiquitin C	0.856
CRIPT	CCDC50	ENSP00000238892	ENSP00000376250	cysteine-rich PDZ-binding protein; Involved in the cytoskeletal anchoring of DLG4 in excitatory synapses (By similarity)	coiled-coil domain containing 50; Involved in EGFR signaling	0.564
CRIPT	UBC	ENSP00000238892	ENSP00000344818	cysteine-rich PDZ-binding protein; Involved in the cytoskeletal anchoring of DLG4 in excitatory synapses (By similarity)	ubiquitin C	0.483
EGFR	CCDC50	ENSP00000275493	ENSP00000376250	epidermal growth factor receptor	coiled-coil domain containing 50; Involved in EGFR signaling	0.916
EGFR	FGF12	ENSP00000275493	ENSP00000413496	epidermal growth factor receptor	fibroblast growth factor 12; Probably involved in nervous system development and function	0.887
EGFR	OTUD7B	ENSP00000275493	ENSP00000358131	epidermal growth factor receptor	OTU domain containing 7B; Negative regulator of the non-canonical NF-kappa-B pathway that acts by mediating deubiquitination of TRAF3, an inhibitor of the NF-kappa-B pathway, thereby acting as a negative regulator of B-cell responses. In response to non-canonical NF- kappa-B stimuli, deubiquitinates ’Lys-48’-linked polyubiquitin chains of TRAF3, preventing TRAF3 proteolysis and over-activation of non-canonical NF-kappa-B. Negatively regulates mucosal immunity against infections. Mediates deubiquitination of EGFR. Has deubiquitinating activity toward ’Lys-11’, ’Lys-48’ or ’Lys-63’- link [...]	0.613
EGFR	RIPK1	ENSP00000275493	ENSP00000259808	epidermal growth factor receptor	receptor (TNFRSF)-interacting serine-threonine kinase 1; Serine-threonine kinase which transduces inflammatory and cell-death signals (programmed necrosis) following death receptors ligation, activation of pathogen recognition receptors (PRRs), and DNA damage. Upon activation of TNFR1 by the TNF-alpha family cytokines, TRADD and TRAF2 are recruited to the receptor. Phosphorylates DAB2IP at ’Ser-728’ in a TNF-alpha-dependent manner, and thereby activates the MAP3K5-JNK apoptotic cascade. Ubiquitination by TRAF2 via ’Lys-63’-link chains acts as a critical enhancer of communication with d [...]	0.622
EGFR	UBB	ENSP00000275493	ENSP00000304697	epidermal growth factor receptor	ubiquitin B	0.973
EGFR	UBC	ENSP00000275493	ENSP00000344818	epidermal growth factor receptor	ubiquitin C	0.999

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