node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
DDX58 | SEC14L1 | ENSP00000369213 | ENSP00000376268 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 58; Innate immune receptor which acts as a cytoplasmic sensor of viral nucleic acids and plays a major role in sensing viral infection and in the activation of a cascade of antiviral responses including the induction of type I interferons and proinflammatory cytokines. Its ligands include- 5’- triphosphorylated ssRNA and dsRNA and short dsRNA (<1 kb in length). In addition to the 5’-triphosphate moiety, blunt-end base pairing at the 5’-end of the RNA is very essential. Overhangs at the non-triphosphorylated end of the dsRNA RNA have no major impac [...] | SEC14-like 1 (S. cerevisiae) | 0.800 |
DDX58 | UBC | ENSP00000369213 | ENSP00000344818 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 58; Innate immune receptor which acts as a cytoplasmic sensor of viral nucleic acids and plays a major role in sensing viral infection and in the activation of a cascade of antiviral responses including the induction of type I interferons and proinflammatory cytokines. Its ligands include- 5’- triphosphorylated ssRNA and dsRNA and short dsRNA (<1 kb in length). In addition to the 5’-triphosphate moiety, blunt-end base pairing at the 5’-end of the RNA is very essential. Overhangs at the non-triphosphorylated end of the dsRNA RNA have no major impac [...] | ubiquitin C | 0.999 |
MOSPD2 | PLD1 | ENSP00000369860 | ENSP00000342793 | motile sperm domain containing 2 | phospholipase D1, phosphatidylcholine-specific; Implicated as a critical step in numerous cellular pathways, including signal transduction, membrane trafficking, and the regulation of mitosis. May be involved in the regulation of perinuclear intravesicular membrane traffic (By similarity) | 0.530 |
MOSPD2 | PLD2 | ENSP00000369860 | ENSP00000263088 | motile sperm domain containing 2 | phospholipase D2; May have a role in signal-induced cytoskeletal regulation and/or endocytosis (By similarity) | 0.530 |
MOSPD2 | SEC14L1 | ENSP00000369860 | ENSP00000376268 | motile sperm domain containing 2 | SEC14-like 1 (S. cerevisiae) | 0.719 |
MOSPD2 | UBC | ENSP00000369860 | ENSP00000344818 | motile sperm domain containing 2 | ubiquitin C | 0.835 |
PCYT1A | SEC14L1 | ENSP00000292823 | ENSP00000376268 | phosphate cytidylyltransferase 1, choline, alpha; Controls phosphatidylcholine synthesis | SEC14-like 1 (S. cerevisiae) | 0.613 |
PCYT1A | UBC | ENSP00000292823 | ENSP00000344818 | phosphate cytidylyltransferase 1, choline, alpha; Controls phosphatidylcholine synthesis | ubiquitin C | 0.796 |
PCYT1B | PLD1 | ENSP00000368439 | ENSP00000342793 | phosphate cytidylyltransferase 1, choline, beta; Controls phosphatidylcholine synthesis | phospholipase D1, phosphatidylcholine-specific; Implicated as a critical step in numerous cellular pathways, including signal transduction, membrane trafficking, and the regulation of mitosis. May be involved in the regulation of perinuclear intravesicular membrane traffic (By similarity) | 0.421 |
PCYT1B | SEC14L1 | ENSP00000368439 | ENSP00000376268 | phosphate cytidylyltransferase 1, choline, beta; Controls phosphatidylcholine synthesis | SEC14-like 1 (S. cerevisiae) | 0.613 |
PLD1 | MOSPD2 | ENSP00000342793 | ENSP00000369860 | phospholipase D1, phosphatidylcholine-specific; Implicated as a critical step in numerous cellular pathways, including signal transduction, membrane trafficking, and the regulation of mitosis. May be involved in the regulation of perinuclear intravesicular membrane traffic (By similarity) | motile sperm domain containing 2 | 0.530 |
PLD1 | PCYT1B | ENSP00000342793 | ENSP00000368439 | phospholipase D1, phosphatidylcholine-specific; Implicated as a critical step in numerous cellular pathways, including signal transduction, membrane trafficking, and the regulation of mitosis. May be involved in the regulation of perinuclear intravesicular membrane traffic (By similarity) | phosphate cytidylyltransferase 1, choline, beta; Controls phosphatidylcholine synthesis | 0.421 |
PLD1 | SEC14L1 | ENSP00000342793 | ENSP00000376268 | phospholipase D1, phosphatidylcholine-specific; Implicated as a critical step in numerous cellular pathways, including signal transduction, membrane trafficking, and the regulation of mitosis. May be involved in the regulation of perinuclear intravesicular membrane traffic (By similarity) | SEC14-like 1 (S. cerevisiae) | 0.707 |
PLD1 | UBC | ENSP00000342793 | ENSP00000344818 | phospholipase D1, phosphatidylcholine-specific; Implicated as a critical step in numerous cellular pathways, including signal transduction, membrane trafficking, and the regulation of mitosis. May be involved in the regulation of perinuclear intravesicular membrane traffic (By similarity) | ubiquitin C | 0.906 |
PLD2 | MOSPD2 | ENSP00000263088 | ENSP00000369860 | phospholipase D2; May have a role in signal-induced cytoskeletal regulation and/or endocytosis (By similarity) | motile sperm domain containing 2 | 0.530 |
PLD2 | SEC14L1 | ENSP00000263088 | ENSP00000376268 | phospholipase D2; May have a role in signal-induced cytoskeletal regulation and/or endocytosis (By similarity) | SEC14-like 1 (S. cerevisiae) | 0.707 |
PLD2 | UBC | ENSP00000263088 | ENSP00000344818 | phospholipase D2; May have a role in signal-induced cytoskeletal regulation and/or endocytosis (By similarity) | ubiquitin C | 0.919 |
PPTC7 | SEC14L1 | ENSP00000346255 | ENSP00000376268 | PTC7 protein phosphatase homolog (S. cerevisiae) | SEC14-like 1 (S. cerevisiae) | 0.635 |
PTPN9 | SEC14L1 | ENSP00000303554 | ENSP00000376268 | protein tyrosine phosphatase, non-receptor type 9; Protein-tyrosine phosphatase that could participate in the transfer of hydrophobic ligands or in functions of the Golgi apparatus | SEC14-like 1 (S. cerevisiae) | 0.864 |
PTPN9 | UBC | ENSP00000303554 | ENSP00000344818 | protein tyrosine phosphatase, non-receptor type 9; Protein-tyrosine phosphatase that could participate in the transfer of hydrophobic ligands or in functions of the Golgi apparatus | ubiquitin C | 0.495 |