node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
GM2A | NPY1R | ENSP00000349687 | ENSP00000354652 | GM2 ganglioside activator; The large binding pocket can accommodate several single chain phospholipids and fatty acids, GM2A also exhibits some calcium-independent phospholipase activity (By similarity). Binds gangliosides and stimulates ganglioside GM2 degradation. It stimulates only the breakdown of ganglioside GM2 and glycolipid GA2 by beta-hexosaminidase A. It extracts single GM2 molecules from membranes and presents them in soluble form to beta- hexosaminidase A for cleavage of N-acetyl-D-galactosamine and conversion to GM3 | neuropeptide Y receptor Y1; Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is NPY > [Pro-34] PYY, PYY and [Leu-31, Pro-34] NPY > NPY (2-36) > [Ile-31, Gln-34] PP and PYY (3-36) > PP > NPY free acid | 0.457 |
GM2A | OSBPL6 | ENSP00000349687 | ENSP00000376293 | GM2 ganglioside activator; The large binding pocket can accommodate several single chain phospholipids and fatty acids, GM2A also exhibits some calcium-independent phospholipase activity (By similarity). Binds gangliosides and stimulates ganglioside GM2 degradation. It stimulates only the breakdown of ganglioside GM2 and glycolipid GA2 by beta-hexosaminidase A. It extracts single GM2 molecules from membranes and presents them in soluble form to beta- hexosaminidase A for cleavage of N-acetyl-D-galactosamine and conversion to GM3 | oxysterol binding protein-like 6 | 0.537 |
MOSPD3 | OSBPL6 | ENSP00000223054 | ENSP00000376293 | motile sperm domain containing 3 | oxysterol binding protein-like 6 | 0.602 |
NFE2L3 | OSBPL6 | ENSP00000056233 | ENSP00000376293 | nuclear factor (erythroid-derived 2)-like 3; Activates erythroid-specific, globin gene expression | oxysterol binding protein-like 6 | 0.549 |
NPY1R | GM2A | ENSP00000354652 | ENSP00000349687 | neuropeptide Y receptor Y1; Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is NPY > [Pro-34] PYY, PYY and [Leu-31, Pro-34] NPY > NPY (2-36) > [Ile-31, Gln-34] PP and PYY (3-36) > PP > NPY free acid | GM2 ganglioside activator; The large binding pocket can accommodate several single chain phospholipids and fatty acids, GM2A also exhibits some calcium-independent phospholipase activity (By similarity). Binds gangliosides and stimulates ganglioside GM2 degradation. It stimulates only the breakdown of ganglioside GM2 and glycolipid GA2 by beta-hexosaminidase A. It extracts single GM2 molecules from membranes and presents them in soluble form to beta- hexosaminidase A for cleavage of N-acetyl-D-galactosamine and conversion to GM3 | 0.457 |
NPY1R | OSBPL6 | ENSP00000354652 | ENSP00000376293 | neuropeptide Y receptor Y1; Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is NPY > [Pro-34] PYY, PYY and [Leu-31, Pro-34] NPY > NPY (2-36) > [Ile-31, Gln-34] PP and PYY (3-36) > PP > NPY free acid | oxysterol binding protein-like 6 | 0.522 |
OSBPL6 | GM2A | ENSP00000376293 | ENSP00000349687 | oxysterol binding protein-like 6 | GM2 ganglioside activator; The large binding pocket can accommodate several single chain phospholipids and fatty acids, GM2A also exhibits some calcium-independent phospholipase activity (By similarity). Binds gangliosides and stimulates ganglioside GM2 degradation. It stimulates only the breakdown of ganglioside GM2 and glycolipid GA2 by beta-hexosaminidase A. It extracts single GM2 molecules from membranes and presents them in soluble form to beta- hexosaminidase A for cleavage of N-acetyl-D-galactosamine and conversion to GM3 | 0.537 |
OSBPL6 | MOSPD3 | ENSP00000376293 | ENSP00000223054 | oxysterol binding protein-like 6 | motile sperm domain containing 3 | 0.602 |
OSBPL6 | NFE2L3 | ENSP00000376293 | ENSP00000056233 | oxysterol binding protein-like 6 | nuclear factor (erythroid-derived 2)-like 3; Activates erythroid-specific, globin gene expression | 0.549 |
OSBPL6 | NPY1R | ENSP00000376293 | ENSP00000354652 | oxysterol binding protein-like 6 | neuropeptide Y receptor Y1; Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is NPY > [Pro-34] PYY, PYY and [Leu-31, Pro-34] NPY > NPY (2-36) > [Ile-31, Gln-34] PP and PYY (3-36) > PP > NPY free acid | 0.522 |
OSBPL6 | PLEK | ENSP00000376293 | ENSP00000234313 | oxysterol binding protein-like 6 | pleckstrin; Major protein kinase C substrate of platelets | 0.590 |
OSBPL6 | PRKD1 | ENSP00000376293 | ENSP00000333568 | oxysterol binding protein-like 6 | protein kinase D1; Serine/threonine-protein kinase that converts transient diacylglycerol (DAG) signals into prolonged physiological effects downstream of PKC, and is involved in the regulation of MAPK8/JNK1 and Ras signaling, Golgi membrane integrity and trafficking, cell survival through NF-kappa-B activation, cell migration, cell differentiation by mediating HDAC7 nuclear export, cell proliferation via MAPK1/3 (ERK1/2) signaling, and plays a role in cardiac hypertrophy, VEGFA-induced angiogenesis, genotoxic-induced apoptosis and flagellin-stimulated inflammatory response. Phosphoryl [...] | 0.613 |
OSBPL6 | PRKD2 | ENSP00000376293 | ENSP00000291281 | oxysterol binding protein-like 6 | protein kinase D2; Serine/threonine-protein kinase that converts transient diacylglycerol (DAG) signals into prolonged physiological effects downstream of PKC, and is involved in the regulation of cell proliferation via MAPK1/3 (ERK1/2) signaling, oxidative stress- induced NF-kappa-B activation, inhibition of HDAC7 transcriptional repression, signaling downstream of T-cell antigen receptor (TCR) and cytokine production, and plays a role in Golgi membrane trafficking, angiogenesis, secretory granule release and cell adhesion. May potentiate mitogenesis induced by the neuropeptide bombes [...] | 0.613 |
OSBPL6 | PRKD3 | ENSP00000376293 | ENSP00000234179 | oxysterol binding protein-like 6 | protein kinase D3; Converts transient diacylglycerol (DAG) signals into prolonged physiological effects, downstream of PKC. Involved in resistance to oxidative stress (By similarity) | 0.613 |
OSBPL6 | VAPA | ENSP00000376293 | ENSP00000345656 | oxysterol binding protein-like 6 | VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa; May play a role in vesicle trafficking | 0.608 |
OSBPL6 | VAPB | ENSP00000376293 | ENSP00000417175 | oxysterol binding protein-like 6 | VAMP (vesicle-associated membrane protein)-associated protein B and C; Participates in the endoplasmic reticulum unfolded protein response (UPR) by inducing ERN1/IRE1 activity. Involved in cellular calcium homeostasis regulation | 0.898 |
PLEK | OSBPL6 | ENSP00000234313 | ENSP00000376293 | pleckstrin; Major protein kinase C substrate of platelets | oxysterol binding protein-like 6 | 0.590 |
PLEK | PRKD1 | ENSP00000234313 | ENSP00000333568 | pleckstrin; Major protein kinase C substrate of platelets | protein kinase D1; Serine/threonine-protein kinase that converts transient diacylglycerol (DAG) signals into prolonged physiological effects downstream of PKC, and is involved in the regulation of MAPK8/JNK1 and Ras signaling, Golgi membrane integrity and trafficking, cell survival through NF-kappa-B activation, cell migration, cell differentiation by mediating HDAC7 nuclear export, cell proliferation via MAPK1/3 (ERK1/2) signaling, and plays a role in cardiac hypertrophy, VEGFA-induced angiogenesis, genotoxic-induced apoptosis and flagellin-stimulated inflammatory response. Phosphoryl [...] | 0.509 |
PLEK | PRKD2 | ENSP00000234313 | ENSP00000291281 | pleckstrin; Major protein kinase C substrate of platelets | protein kinase D2; Serine/threonine-protein kinase that converts transient diacylglycerol (DAG) signals into prolonged physiological effects downstream of PKC, and is involved in the regulation of cell proliferation via MAPK1/3 (ERK1/2) signaling, oxidative stress- induced NF-kappa-B activation, inhibition of HDAC7 transcriptional repression, signaling downstream of T-cell antigen receptor (TCR) and cytokine production, and plays a role in Golgi membrane trafficking, angiogenesis, secretory granule release and cell adhesion. May potentiate mitogenesis induced by the neuropeptide bombes [...] | 0.410 |
PLEK | PRKD3 | ENSP00000234313 | ENSP00000234179 | pleckstrin; Major protein kinase C substrate of platelets | protein kinase D3; Converts transient diacylglycerol (DAG) signals into prolonged physiological effects, downstream of PKC. Involved in resistance to oxidative stress (By similarity) | 0.499 |