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STRINGSTRING
MOSPD3 MOSPD3 VAPB VAPB VAPA VAPA PRKD2 PRKD2 OSBPL6 OSBPL6 NFE2L3 NFE2L3 PLEK PLEK PRKD1 PRKD1 NPY1R NPY1R PRKD3 PRKD3 GM2A GM2A
"OSBPL6" - oxysterol binding protein-like 6 in Homo sapiens
Nodes:
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
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colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
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gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
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[Homology]
Score
OSBPL6oxysterol binding protein-like 6 (959 aa)    
Predicted Functional Partners:
VAPB
VAMP (vesicle-associated membrane protein)-associated protein B and C; Participates in the endoplasmic reticulum unfolded protein response (UPR) by inducing ERN1/IRE1 activity. Involved in cellular calcium homeostasis regulation (243 aa)
        score_image   score_image   0.898
PRKD1
protein kinase D1; Serine/threonine-protein kinase that converts transient diacylglycerol (DAG) signals into prolonged physiological effects downstream of PKC, and is involved in the regulation of MAPK8/JNK1 and Ras signaling, Golgi membrane integrity and trafficking, cell survival through NF-kappa-B activation, cell migration, cell differentiation by mediating HDAC7 nuclear export, cell proliferation via MAPK1/3 (ERK1/2) signaling, and plays a role in cardiac hypertrophy, VEGFA-induced angiogenesis, genotoxic-induced apoptosis and flagellin-stimulated inflammatory response. Phosphoryl [...] (912 aa)
            score_image   0.613
PRKD2
protein kinase D2; Serine/threonine-protein kinase that converts transient diacylglycerol (DAG) signals into prolonged physiological effects downstream of PKC, and is involved in the regulation of cell proliferation via MAPK1/3 (ERK1/2) signaling, oxidative stress- induced NF-kappa-B activation, inhibition of HDAC7 transcriptional repression, signaling downstream of T-cell antigen receptor (TCR) and cytokine production, and plays a role in Golgi membrane trafficking, angiogenesis, secretory granule release and cell adhesion. May potentiate mitogenesis induced by the neuropeptide bombes [...] (878 aa)
            score_image   0.613
PRKD3
protein kinase D3; Converts transient diacylglycerol (DAG) signals into prolonged physiological effects, downstream of PKC. Involved in resistance to oxidative stress (By similarity) (890 aa)
            score_image   0.613
VAPA
VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa; May play a role in vesicle trafficking (294 aa)
        score_image   score_image   0.608
MOSPD3
motile sperm domain containing 3 (235 aa)
        score_image   score_image   0.602
PLEK
pleckstrin; Major protein kinase C substrate of platelets (350 aa)
            score_image   0.590
NFE2L3
nuclear factor (erythroid-derived 2)-like 3; Activates erythroid-specific, globin gene expression (694 aa)
            score_image   0.549
GM2A
GM2 ganglioside activator; The large binding pocket can accommodate several single chain phospholipids and fatty acids, GM2A also exhibits some calcium-independent phospholipase activity (By similarity). Binds gangliosides and stimulates ganglioside GM2 degradation. It stimulates only the breakdown of ganglioside GM2 and glycolipid GA2 by beta-hexosaminidase A. It extracts single GM2 molecules from membranes and presents them in soluble form to beta- hexosaminidase A for cleavage of N-acetyl-D-galactosamine and conversion to GM3 (193 aa)
            score_image   0.537
NPY1R
neuropeptide Y receptor Y1; Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is NPY > [Pro-34] PYY, PYY and [Leu-31, Pro-34] NPY > NPY (2-36) > [Ile-31, Gln-34] PP and PYY (3-36) > PP > NPY free acid (384 aa)
            score_image   0.522
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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