Full Link:
  • Version:
  • 10.0 (archived version)
STRINGSTRING
NCAM1 NCAM1 RTP1 RTP1 REEP2 REEP2 LRP1 LRP1 RIC8B RIC8B TMTC1 TMTC1 GNAS GNAS GNAQ GNAQ GNAL GNAL GNA11 GNA11 GNAI3 GNAI3
"RIC8B" - resistance to inhibitors of cholinesterase 8 homolog B (C. elegans) in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
RIC8Bresistance to inhibitors of cholinesterase 8 homolog B (C. elegans); Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins by exchanging bound GDP for free GTP (By similarity). Able to potentiate G(olf)-alpha- dependent cAMP accumulation suggesting that it may be an important component for odorant signal transduction (By similarity) (520 aa)    
Predicted Functional Partners:
GNAQ
guanine nucleotide binding protein (G protein), q polypeptide; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Regulates B-cell selection and survival and is required to prevent B-cell-dependent autoimmunity. Regulates chemotaxis of BM-derived neutrophils and dendritic cells (in vitro) (By similarity) (359 aa)
        score_image   score_image   0.962
GNA11
guanine nucleotide binding protein (G protein), alpha 11 (Gq class); Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Acts as an activator of phospholipase C (359 aa)
        score_image   score_image   0.907
GNAL
guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. G(olf) alpha mediates signal transduction within the olfactory neuroepithelium and the basal ganglia. May be involved in some aspect of visual transduction, and in mediating the effect of one or more hormones/neurotransmitters (458 aa)
            score_image   0.900
GNAS
GNAS complex locus; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(s) protein is involved in hormonal regulation of adenylate cyclase- it activates the cyclase in response to beta-adrenergic stimuli. XLas isoforms interact with the same set of receptors as Gnas isoforms (By similarity) (1037 aa)
        score_image   score_image   0.872
GNAI3
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. G(k) is the stimulatory G protein of receptor- regulated K(+) channels. The active GTP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division (354 aa)
        score_image   score_image   0.694
TMTC1
transmembrane and tetratricopeptide repeat containing 1 (882 aa)
            score_image   0.681
REEP2
receptor accessory protein 2; May enhance the cell surface expression of odorant receptors (By similarity) (252 aa)
            score_image   0.653
NCAM1
neural cell adhesion molecule 1 (848 aa)
            score_image   0.648
LRP1
low density lipoprotein receptor-related protein 1; Endocytic receptor involved in endocytosis and in phagocytosis of apoptotic cells. Required for early embryonic development. Involved in cellular lipid homeostasis. Involved in the plasma clearance of chylomicron remnants and activated LRPAP1 (alpha 2-macroglobulin), as well as the local metabolism of complexes between plasminogen activators and their endogenous inhibitors. May modulate cellular events, such as APP metabolism, kinase-dependent intracellular signaling, neuronal calcium signaling as well as neurotransmission (4544 aa)
        score_image   score_image   0.589
RTP1
receptor (chemosensory) transporter protein 1; Specifically promotes functional cell surface expression of olfactory receptors, but not of other GPCRs (By similarity) (263 aa)
            score_image   0.583
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Server load: low (24%)