CSH2 protein (Homo sapiens) - STRING network view

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CSH2

chorionic somatomammotropin hormone 2 (217 aa)

Predicted Functional Partners:

CMAS

0.846

GHR

0.825

LIFR

0.824

PRLR

0.812

JAK2

0.801

IFNAR2

0.800

IL20RA

0.800

ENSG00000258728

0.800

IL12RB1

0.800

CSF2RA

0.800

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CMAS	CSH2	ENSP00000229329	ENSP00000376623	cytidine monophosphate N-acetylneuraminic acid synthetase; Catalyzes the activation of N-acetylneuraminic acid (NeuNAc) to cytidine 5’-monophosphate N-acetylneuraminic acid (CMP-NeuNAc), a substrate required for the addition of sialic acid. Has some activity toward NeuNAc, N-glycolylneuraminic acid (Neu5Gc) or 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN)	chorionic somatomammotropin hormone 2	0.846
CSF2RA	CSH2	ENSP00000394227	ENSP00000376623	colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)	chorionic somatomammotropin hormone 2	0.800
CSF2RA	JAK2	ENSP00000394227	ENSP00000371067	colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)	Janus kinase 2; Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin (THPO); or type II receptors including IFN-alpha, IFN-beta, IFN-gamma and multiple interleukins. Following ligand-binding to cell surface receptors, phosphorylate [...]	0.939
CSH2	CMAS	ENSP00000376623	ENSP00000229329	chorionic somatomammotropin hormone 2	cytidine monophosphate N-acetylneuraminic acid synthetase; Catalyzes the activation of N-acetylneuraminic acid (NeuNAc) to cytidine 5’-monophosphate N-acetylneuraminic acid (CMP-NeuNAc), a substrate required for the addition of sialic acid. Has some activity toward NeuNAc, N-glycolylneuraminic acid (Neu5Gc) or 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN)	0.846
CSH2	CSF2RA	ENSP00000376623	ENSP00000394227	chorionic somatomammotropin hormone 2	colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)	0.800
CSH2	ENSG00000258728	ENSP00000376623	ENSP00000451792	chorionic somatomammotropin hormone 2	Uncharacterized protein	0.800
CSH2	GHR	ENSP00000376623	ENSP00000230882	chorionic somatomammotropin hormone 2	growth hormone receptor; Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to the JAK2/STAT5 pathway (By similarity)	0.825
CSH2	IFNAR2	ENSP00000376623	ENSP00000343957	chorionic somatomammotropin hormone 2	interferon (alpha, beta and omega) receptor 2; Associates with IFNAR1 to form the type I interferon receptor. Receptor for interferons alpha and beta. Involved in IFN-mediated STAT1, STAT2 and STAT3 activation. Isoform 1 and isoform 2 are directly involved in signal transduction due to their association with the TYR kinase, JAK1. Isoform 3 is a potent inhibitor of type I IFN receptor activity	0.800
CSH2	IL12RB1	ENSP00000376623	ENSP00000403103	chorionic somatomammotropin hormone 2	interleukin 12 receptor, beta 1; Functions as an interleukin receptor which binds interleukin-12 with low affinity and is involved in IL12 transduction. Associated with IL12RB2 it forms a functional, high affinity receptor for IL12. Associates also with IL23R to form the interleukin-23 receptor which functions in IL23 signal transduction probably through activation of the Jak-Stat signaling cascade	0.800
CSH2	IL20RA	ENSP00000376623	ENSP00000314976	chorionic somatomammotropin hormone 2	interleukin 20 receptor, alpha; The IL20RA/IL20RB dimer is a receptor for IL19, IL20 and IL24. The IL20RA/IL10RB dimer is a receptor for IL26	0.800
CSH2	JAK2	ENSP00000376623	ENSP00000371067	chorionic somatomammotropin hormone 2	Janus kinase 2; Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin (THPO); or type II receptors including IFN-alpha, IFN-beta, IFN-gamma and multiple interleukins. Following ligand-binding to cell surface receptors, phosphorylate [...]	0.801
CSH2	LIFR	ENSP00000376623	ENSP00000263409	chorionic somatomammotropin hormone 2	leukemia inhibitory factor receptor alpha; Signal-transducing molecule. May have a common pathway with IL6ST. The soluble form inhibits the biological activity of LIF by blocking its binding to receptors on target cells	0.824
CSH2	PRLR	ENSP00000376623	ENSP00000371432	chorionic somatomammotropin hormone 2	prolactin receptor	0.812
ENSG00000258728	CSH2	ENSP00000451792	ENSP00000376623	Uncharacterized protein	chorionic somatomammotropin hormone 2	0.800
ENSG00000258728	JAK2	ENSP00000451792	ENSP00000371067	Uncharacterized protein	Janus kinase 2; Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin (THPO); or type II receptors including IFN-alpha, IFN-beta, IFN-gamma and multiple interleukins. Following ligand-binding to cell surface receptors, phosphorylate [...]	0.800
GHR	CSH2	ENSP00000230882	ENSP00000376623	growth hormone receptor; Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to the JAK2/STAT5 pathway (By similarity)	chorionic somatomammotropin hormone 2	0.825
GHR	JAK2	ENSP00000230882	ENSP00000371067	growth hormone receptor; Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to the JAK2/STAT5 pathway (By similarity)	Janus kinase 2; Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin (THPO); or type II receptors including IFN-alpha, IFN-beta, IFN-gamma and multiple interleukins. Following ligand-binding to cell surface receptors, phosphorylate [...]	0.999
GHR	LIFR	ENSP00000230882	ENSP00000263409	growth hormone receptor; Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to the JAK2/STAT5 pathway (By similarity)	leukemia inhibitory factor receptor alpha; Signal-transducing molecule. May have a common pathway with IL6ST. The soluble form inhibits the biological activity of LIF by blocking its binding to receptors on target cells	0.620
GHR	PRLR	ENSP00000230882	ENSP00000371432	growth hormone receptor; Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to the JAK2/STAT5 pathway (By similarity)	prolactin receptor	0.926
IFNAR2	CSH2	ENSP00000343957	ENSP00000376623	interferon (alpha, beta and omega) receptor 2; Associates with IFNAR1 to form the type I interferon receptor. Receptor for interferons alpha and beta. Involved in IFN-mediated STAT1, STAT2 and STAT3 activation. Isoform 1 and isoform 2 are directly involved in signal transduction due to their association with the TYR kinase, JAK1. Isoform 3 is a potent inhibitor of type I IFN receptor activity	chorionic somatomammotropin hormone 2	0.800

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