Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes:
protein of unknown 3D structure
protein of unknown 3D structure
large nodes:
some 3D structure is known or predicted
some 3D structure is known or predicted
Node Color
colored nodes:
query proteins and first shell of interactors
query proteins and first shell of interactors
white nodes:
second shell of interactors
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
|
Your Input:
|
Neighborhood |
Gene Fusion |
Cooccurence |
Coexpression |
Experiments |
Databases |
Textmining |
[Homology] |
Score |
|||||
 | C7orf49 | chromosome 7 open reading frame 49; May act as a regulator of proteasome (By similarity) (157 aa) | ||||||||||||
Predicted Functional Partners:
| ||||||||||||||
 | AMHR2 | anti-Mullerian hormone receptor, type II; On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for anti-Muellerian hormone (573 aa) |
 |
0.747 | ||||||||||
 | CTNND2 | catenin (cadherin-associated protein), delta 2 (1225 aa) |
|
0.690 | ||||||||||
 | PRKG2 | protein kinase, cGMP-dependent, type II (762 aa) |
|
0.687 | ||||||||||
 | CDKN1C | cyclin-dependent kinase inhibitor 1C (p57, Kip2); Potent tight-binding inhibitor of several G1 cyclin/CDK complexes (cyclin E-CDK2, cyclin D2-CDK4, and cyclin A-CDK2) and, to lesser extent, of the mitotic cyclin B-CDC2. Negative regulator of cell proliferation. May play a role in maintenance of the non- proliferative state throughout life (316 aa) |
|
0.633 | ||||||||||
 | ERCC6L2 | excision repair cross-complementing rodent repair deficiency, complementation group 6-like 2 (712 aa) |
|
0.613 | ||||||||||
 | COL10A1 | collagen, type X, alpha 1; Type X collagen is a product of hypertrophic chondrocytes and has been localized to presumptive mineralization zones of hyaline cartilage (680 aa) |
|
0.610 | ||||||||||
 | KCNE1 | potassium voltage-gated channel, Isk-related family, member 1; Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. Assembled with KCNQ1/KVLQT1 is proposed to form the slowly activating delayed rectifier cardiac potassium (IKs) channel. The outward current reaches its steady state only after 50 seconds. Assembled with KCNH2/HERG may modulate the rapidly activating component of the delayed rectifying potassium current in heart (IKr) (129 aa) |
|
0.563 | ||||||||||
 | ROPN1L | rhophilin associated tail protein 1-like (230 aa) |
|
0.562 | ||||||||||
 | SLC6A3 | solute carrier family 6 (neurotransmitter transporter, dopamine), member 3; Amine transporter. Terminates the action of dopamine by its high affinity sodium-dependent reuptake into presynaptic terminals (620 aa) |
|
0.539 | ||||||||||
 | TBATA | thymus, brain and testes associated; May play a role in spermatid differentiation (By similarity). Modulates thymic stromal cell proliferation and thymus function (By similarity) (351 aa) |
|
0.536 | ||||||||||
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Other names: H. sapiens, Homo, Homo sapiens, human, man
Share
