node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CMPK2 | DTYMK | ENSP00000256722 | ENSP00000304802 | cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial; May participate in dUTP and dCTP synthesis in mitochondria. Is able to phosphorylate dUMP, dCMP, CMP, UMP and monophosphates of the pyrimidine nucleoside analogs ddC, dFdC, araC, BVDU and FdUrd with ATP as phosphate donor. Efficacy is highest for dUMP followed by dCMP; CMP and UMP are poor substrates. May be involved in mtDNA depletion caused by long term treatment with ddC or other pyrimidine analogs | deoxythymidylate kinase (thymidylate kinase); Catalyzes the conversion of dTMP to dTDP | 0.861 |
CMPK2 | NME1 | ENSP00000256722 | ENSP00000013034 | cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial; May participate in dUTP and dCTP synthesis in mitochondria. Is able to phosphorylate dUMP, dCMP, CMP, UMP and monophosphates of the pyrimidine nucleoside analogs ddC, dFdC, araC, BVDU and FdUrd with ATP as phosphate donor. Efficacy is highest for dUMP followed by dCMP; CMP and UMP are poor substrates. May be involved in mtDNA depletion caused by long term treatment with ddC or other pyrimidine analogs | NME/NM23 nucleoside diphosphate kinase 1; Major role in the synthesis of nucleoside triphosphates other than ATP. Possesses nucleoside-diphosphate kinase, serine/threonine-specific protein kinase, geranyl and farnesyl pyrophosphate kinase, histidine protein kinase and 3’-5’ exonuclease activities. Involved in cell proliferation, differentiation and development, signal transduction, G protein- coupled receptor endocytosis, and gene expression. Required for neural development including neural patterning and cell fate determination | 0.947 |
CMPK2 | NME2 | ENSP00000256722 | ENSP00000376889 | cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial; May participate in dUTP and dCTP synthesis in mitochondria. Is able to phosphorylate dUMP, dCMP, CMP, UMP and monophosphates of the pyrimidine nucleoside analogs ddC, dFdC, araC, BVDU and FdUrd with ATP as phosphate donor. Efficacy is highest for dUMP followed by dCMP; CMP and UMP are poor substrates. May be involved in mtDNA depletion caused by long term treatment with ddC or other pyrimidine analogs | NME/NM23 nucleoside diphosphate kinase 2; Major role in the synthesis of nucleoside triphosphates other than ATP. Negatively regulates Rho activity by interacting with AKAP13/LBC. Acts as a transcriptional activator of the MYC gene; binds DNA non-specifically (PubMed-8392752). Exhibits histidine protein kinase activity | 0.946 |
CMPK2 | RRM1 | ENSP00000256722 | ENSP00000300738 | cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial; May participate in dUTP and dCTP synthesis in mitochondria. Is able to phosphorylate dUMP, dCMP, CMP, UMP and monophosphates of the pyrimidine nucleoside analogs ddC, dFdC, araC, BVDU and FdUrd with ATP as phosphate donor. Efficacy is highest for dUMP followed by dCMP; CMP and UMP are poor substrates. May be involved in mtDNA depletion caused by long term treatment with ddC or other pyrimidine analogs | ribonucleotide reductase M1; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) | 0.938 |
CMPK2 | UBC | ENSP00000256722 | ENSP00000344818 | cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial; May participate in dUTP and dCTP synthesis in mitochondria. Is able to phosphorylate dUMP, dCMP, CMP, UMP and monophosphates of the pyrimidine nucleoside analogs ddC, dFdC, araC, BVDU and FdUrd with ATP as phosphate donor. Efficacy is highest for dUMP followed by dCMP; CMP and UMP are poor substrates. May be involved in mtDNA depletion caused by long term treatment with ddC or other pyrimidine analogs | ubiquitin C | 0.545 |
DTYMK | CMPK2 | ENSP00000304802 | ENSP00000256722 | deoxythymidylate kinase (thymidylate kinase); Catalyzes the conversion of dTMP to dTDP | cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial; May participate in dUTP and dCTP synthesis in mitochondria. Is able to phosphorylate dUMP, dCMP, CMP, UMP and monophosphates of the pyrimidine nucleoside analogs ddC, dFdC, araC, BVDU and FdUrd with ATP as phosphate donor. Efficacy is highest for dUMP followed by dCMP; CMP and UMP are poor substrates. May be involved in mtDNA depletion caused by long term treatment with ddC or other pyrimidine analogs | 0.861 |
DTYMK | GUK1 | ENSP00000304802 | ENSP00000355689 | deoxythymidylate kinase (thymidylate kinase); Catalyzes the conversion of dTMP to dTDP | guanylate kinase 1; Essential for recycling GMP and indirectly, cGMP | 0.556 |
DTYMK | NME1 | ENSP00000304802 | ENSP00000013034 | deoxythymidylate kinase (thymidylate kinase); Catalyzes the conversion of dTMP to dTDP | NME/NM23 nucleoside diphosphate kinase 1; Major role in the synthesis of nucleoside triphosphates other than ATP. Possesses nucleoside-diphosphate kinase, serine/threonine-specific protein kinase, geranyl and farnesyl pyrophosphate kinase, histidine protein kinase and 3’-5’ exonuclease activities. Involved in cell proliferation, differentiation and development, signal transduction, G protein- coupled receptor endocytosis, and gene expression. Required for neural development including neural patterning and cell fate determination | 0.954 |
DTYMK | NME2 | ENSP00000304802 | ENSP00000376889 | deoxythymidylate kinase (thymidylate kinase); Catalyzes the conversion of dTMP to dTDP | NME/NM23 nucleoside diphosphate kinase 2; Major role in the synthesis of nucleoside triphosphates other than ATP. Negatively regulates Rho activity by interacting with AKAP13/LBC. Acts as a transcriptional activator of the MYC gene; binds DNA non-specifically (PubMed-8392752). Exhibits histidine protein kinase activity | 0.956 |
DTYMK | RRM1 | ENSP00000304802 | ENSP00000300738 | deoxythymidylate kinase (thymidylate kinase); Catalyzes the conversion of dTMP to dTDP | ribonucleotide reductase M1; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) | 0.954 |
DTYMK | UBC | ENSP00000304802 | ENSP00000344818 | deoxythymidylate kinase (thymidylate kinase); Catalyzes the conversion of dTMP to dTDP | ubiquitin C | 0.666 |
GUK1 | DTYMK | ENSP00000355689 | ENSP00000304802 | guanylate kinase 1; Essential for recycling GMP and indirectly, cGMP | deoxythymidylate kinase (thymidylate kinase); Catalyzes the conversion of dTMP to dTDP | 0.556 |
GUK1 | NME1 | ENSP00000355689 | ENSP00000013034 | guanylate kinase 1; Essential for recycling GMP and indirectly, cGMP | NME/NM23 nucleoside diphosphate kinase 1; Major role in the synthesis of nucleoside triphosphates other than ATP. Possesses nucleoside-diphosphate kinase, serine/threonine-specific protein kinase, geranyl and farnesyl pyrophosphate kinase, histidine protein kinase and 3’-5’ exonuclease activities. Involved in cell proliferation, differentiation and development, signal transduction, G protein- coupled receptor endocytosis, and gene expression. Required for neural development including neural patterning and cell fate determination | 0.945 |
GUK1 | NME2 | ENSP00000355689 | ENSP00000376889 | guanylate kinase 1; Essential for recycling GMP and indirectly, cGMP | NME/NM23 nucleoside diphosphate kinase 2; Major role in the synthesis of nucleoside triphosphates other than ATP. Negatively regulates Rho activity by interacting with AKAP13/LBC. Acts as a transcriptional activator of the MYC gene; binds DNA non-specifically (PubMed-8392752). Exhibits histidine protein kinase activity | 0.946 |
GUK1 | PKM | ENSP00000355689 | ENSP00000320171 | guanylate kinase 1; Essential for recycling GMP and indirectly, cGMP | pyruvate kinase, muscle | 0.913 |
GUK1 | POLR1B | ENSP00000355689 | ENSP00000263331 | guanylate kinase 1; Essential for recycling GMP and indirectly, cGMP | polymerase (RNA) I polypeptide B, 128kDa; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest core component of RNA polymerase I which synthesizes ribosomal RNA precursors. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol I is composed of mobile elements and RPA2 is part of the core element with the central large cleft and probably a clamp element that moves to open and close the cleft (By similarity) | 0.455 |
GUK1 | POLR2B | ENSP00000355689 | ENSP00000312735 | guanylate kinase 1; Essential for recycling GMP and indirectly, cGMP | polymerase (RNA) II (DNA directed) polypeptide B, 140kDa; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each ot [...] | 0.405 |
GUK1 | RRM1 | ENSP00000355689 | ENSP00000300738 | guanylate kinase 1; Essential for recycling GMP and indirectly, cGMP | ribonucleotide reductase M1; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) | 0.918 |
GUK1 | UBC | ENSP00000355689 | ENSP00000344818 | guanylate kinase 1; Essential for recycling GMP and indirectly, cGMP | ubiquitin C | 0.727 |
MYC | NME1 | ENSP00000367207 | ENSP00000013034 | v-myc myelocytomatosis viral oncogene homolog (avian); Participates in the regulation of gene transcription. Binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5’-CAC[GA]TG-3’. Seems to activate the transcription of growth-related genes | NME/NM23 nucleoside diphosphate kinase 1; Major role in the synthesis of nucleoside triphosphates other than ATP. Possesses nucleoside-diphosphate kinase, serine/threonine-specific protein kinase, geranyl and farnesyl pyrophosphate kinase, histidine protein kinase and 3’-5’ exonuclease activities. Involved in cell proliferation, differentiation and development, signal transduction, G protein- coupled receptor endocytosis, and gene expression. Required for neural development including neural patterning and cell fate determination | 0.955 |