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MAPK9 MAPK9 JUN JUN BCL2L1 BCL2L1 FOXO3 FOXO3 BCL2L11 BCL2L11 BCL2 BCL2 DYNLL1 DYNLL1 MAPK8 MAPK8 MCL1 MCL1 BAX BAX BCL2L2 BCL2L2
"BCL2L11" - BCL2-like 11 (apoptosis facilitator) in Homo sapiens
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Predicted Interactions
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BCL2L11BCL2-like 11 (apoptosis facilitator) (198 aa)    
Predicted Functional Partners:
BCL2
B-cell CLL/lymphoma 2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1) (239 aa)
        score_image score_image score_image   0.999
BCL2L1
BCL2-like 1; Potent inhibitor of cell death. Inhibits activation of caspases (By similarity). Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis (233 aa)
        score_image score_image score_image   0.999
MCL1
myeloid cell leukemia sequence 1 (BCL2-related) (350 aa)
        score_image score_image score_image   0.999
BAX
BCL2-associated X protein (218 aa)
        score_image score_image score_image   0.999
BCL2L2
BCL2-like 2; Promotes cell survival. Blocks dexamethasone-induced apoptosis. Mediates survival of postmitotic Sertoli cells by suppressing death-promoting activity of BAX (193 aa)
        score_image   score_image   0.999
DYNLL1
dynein, light chain, LC8-type 1; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures (89 aa)
        score_image score_image score_image   0.998
MAPK8
mitogen-activated protein kinase 8; Serine/threonine-protein kinase involved in various processes such as cell proliferation, differentiation, migration, transformation and programmed cell death. Extracellular stimuli such as proinflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK8/JNK1. In turn, MAPK8/JNK1 phosphorylates a number of transcription factors, primarily components of AP-1 such as JU [...] (427 aa)
        score_image score_image score_image   0.997
FOXO3
forkhead box O3; Transcriptional activator which triggers apoptosis in the absence of survival factors, including neuronal cell death upon oxidative stress. Recognizes and binds to the DNA sequence 5’-[AG]TAAA[TC]A-3’. Participates in post-transcriptional regulation of MYC- following phosphorylation by MAPKAPK5, promotes induction of miR-34b and miR-34c expression, 2 post- transcriptional regulators of MYC that bind to the 3’UTR of MYC transcript and prevent its translation (673 aa)
        score_image score_image score_image   0.997
MAPK9
mitogen-activated protein kinase 9 (424 aa)
        score_image score_image score_image   0.993
JUN
jun proto-oncogene; Transcription factor that recognizes and binds to the enhancer heptamer motif 5’-TGA[CG]TCA-3’. Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation (331 aa)
          score_image score_image   0.989
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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