AASS protein (Homo sapiens) - STRING network view

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AASS

aminoadipate-semialdehyde synthase; Bifunctional enzyme that catalyzes the first two steps in lysine degradation. The N-terminal and the C-terminal contain lysine-ketoglutarate reductase and saccharopine dehydrogenase activity, respectively (926 aa)

Predicted Functional Partners:

ALDH7A1

0.964

AGXT2L2

0.913

SCCPDH

0.910

AASDH

0.896

AASDHPPT

0.877

BTD

0.823

SRM

0.682

LAX1

0.681

ENSG00000268412

0.651

TRMT112

0.651

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AASDH	AASDHPPT	ENSP00000205214	ENSP00000278618	aminoadipate-semialdehyde dehydrogenase	aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase; Catalyzes the post-translational modification of target proteins by phosphopantetheine. Can transfer the 4’- phosphopantetheine moiety from coenzyme A to a serine residue of a broad range of acceptors, such as the acyl carrier domain of FASN	0.989
AASDH	AASS	ENSP00000205214	ENSP00000377040	aminoadipate-semialdehyde dehydrogenase	aminoadipate-semialdehyde synthase; Bifunctional enzyme that catalyzes the first two steps in lysine degradation. The N-terminal and the C-terminal contain lysine-ketoglutarate reductase and saccharopine dehydrogenase activity, respectively	0.896
AASDHPPT	AASDH	ENSP00000278618	ENSP00000205214	aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase; Catalyzes the post-translational modification of target proteins by phosphopantetheine. Can transfer the 4’- phosphopantetheine moiety from coenzyme A to a serine residue of a broad range of acceptors, such as the acyl carrier domain of FASN	aminoadipate-semialdehyde dehydrogenase	0.989
AASDHPPT	AASS	ENSP00000278618	ENSP00000377040	aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase; Catalyzes the post-translational modification of target proteins by phosphopantetheine. Can transfer the 4’- phosphopantetheine moiety from coenzyme A to a serine residue of a broad range of acceptors, such as the acyl carrier domain of FASN	aminoadipate-semialdehyde synthase; Bifunctional enzyme that catalyzes the first two steps in lysine degradation. The N-terminal and the C-terminal contain lysine-ketoglutarate reductase and saccharopine dehydrogenase activity, respectively	0.877
AASS	AASDH	ENSP00000377040	ENSP00000205214	aminoadipate-semialdehyde synthase; Bifunctional enzyme that catalyzes the first two steps in lysine degradation. The N-terminal and the C-terminal contain lysine-ketoglutarate reductase and saccharopine dehydrogenase activity, respectively	aminoadipate-semialdehyde dehydrogenase	0.896
AASS	AASDHPPT	ENSP00000377040	ENSP00000278618	aminoadipate-semialdehyde synthase; Bifunctional enzyme that catalyzes the first two steps in lysine degradation. The N-terminal and the C-terminal contain lysine-ketoglutarate reductase and saccharopine dehydrogenase activity, respectively	aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase; Catalyzes the post-translational modification of target proteins by phosphopantetheine. Can transfer the 4’- phosphopantetheine moiety from coenzyme A to a serine residue of a broad range of acceptors, such as the acyl carrier domain of FASN	0.877
AASS	AGXT2L2	ENSP00000377040	ENSP00000310978	aminoadipate-semialdehyde synthase; Bifunctional enzyme that catalyzes the first two steps in lysine degradation. The N-terminal and the C-terminal contain lysine-ketoglutarate reductase and saccharopine dehydrogenase activity, respectively	alanine-glyoxylate aminotransferase 2-like 2; Catalyzes the pyridoxal-phosphate-dependent breakdown of 5-phosphohydroxy-L-lysine, converting it to ammonia, inorganic phosphate and 2-aminoadipate semialdehyde	0.913
AASS	ALDH7A1	ENSP00000377040	ENSP00000387123	aminoadipate-semialdehyde synthase; Bifunctional enzyme that catalyzes the first two steps in lysine degradation. The N-terminal and the C-terminal contain lysine-ketoglutarate reductase and saccharopine dehydrogenase activity, respectively	aldehyde dehydrogenase 7 family, member A1; Multifunctional enzyme mediating important protective effects. Metabolizes betaine aldehyde to betaine, an important cellular osmolyte and methyl donor. Protects cells from oxidative stress by metabolizing a number of lipid peroxidation-derived aldehydes. Involved in lysine catabolism	0.964
AASS	BTD	ENSP00000377040	ENSP00000306477	aminoadipate-semialdehyde synthase; Bifunctional enzyme that catalyzes the first two steps in lysine degradation. The N-terminal and the C-terminal contain lysine-ketoglutarate reductase and saccharopine dehydrogenase activity, respectively	biotinidase; Catalytic release of biotin from biocytin, the product of biotin-dependent carboxylases degradation	0.823
AASS	ENSG00000268412	ENSP00000377040	ENSP00000472299	aminoadipate-semialdehyde synthase; Bifunctional enzyme that catalyzes the first two steps in lysine degradation. The N-terminal and the C-terminal contain lysine-ketoglutarate reductase and saccharopine dehydrogenase activity, respectively	Uncharacterized protein	0.651
AASS	LAX1	ENSP00000377040	ENSP00000406970	aminoadipate-semialdehyde synthase; Bifunctional enzyme that catalyzes the first two steps in lysine degradation. The N-terminal and the C-terminal contain lysine-ketoglutarate reductase and saccharopine dehydrogenase activity, respectively	lymphocyte transmembrane adaptor 1; Negatively regulates TCR (T-cell antigen receptor)- mediated signaling in T-cells and BCR (B-cell antigen receptor)- mediated signaling in B-cells	0.681
AASS	SCCPDH	ENSP00000377040	ENSP00000355467	aminoadipate-semialdehyde synthase; Bifunctional enzyme that catalyzes the first two steps in lysine degradation. The N-terminal and the C-terminal contain lysine-ketoglutarate reductase and saccharopine dehydrogenase activity, respectively	saccharopine dehydrogenase (putative)	0.910
AASS	SRM	ENSP00000377040	ENSP00000366156	aminoadipate-semialdehyde synthase; Bifunctional enzyme that catalyzes the first two steps in lysine degradation. The N-terminal and the C-terminal contain lysine-ketoglutarate reductase and saccharopine dehydrogenase activity, respectively	spermidine synthase; Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM). Has a strong preference for putrescine as substrate, and has very low activity towards 1,3-diaminopropane. Has extremely low activity towards spermidine	0.682
AASS	TRMT112	ENSP00000377040	ENSP00000438349	aminoadipate-semialdehyde synthase; Bifunctional enzyme that catalyzes the first two steps in lysine degradation. The N-terminal and the C-terminal contain lysine-ketoglutarate reductase and saccharopine dehydrogenase activity, respectively	tRNA methyltransferase 11-2 homolog (S. cerevisiae); Participates both in methylation of protein and tRNA species. The heterodimer with HEMK2/N6AMT1 catalyzes N5- methylation of ETF1 on ’Gln-185’, using S-adenosyl L-methionine as methyl donor. The heterodimer with ALKBH8 catalyzes the methylation of 5-carboxymethyl uridine to 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in target tRNA species	0.651
AGXT2L2	AASS	ENSP00000310978	ENSP00000377040	alanine-glyoxylate aminotransferase 2-like 2; Catalyzes the pyridoxal-phosphate-dependent breakdown of 5-phosphohydroxy-L-lysine, converting it to ammonia, inorganic phosphate and 2-aminoadipate semialdehyde	aminoadipate-semialdehyde synthase; Bifunctional enzyme that catalyzes the first two steps in lysine degradation. The N-terminal and the C-terminal contain lysine-ketoglutarate reductase and saccharopine dehydrogenase activity, respectively	0.913
AGXT2L2	ALDH7A1	ENSP00000310978	ENSP00000387123	alanine-glyoxylate aminotransferase 2-like 2; Catalyzes the pyridoxal-phosphate-dependent breakdown of 5-phosphohydroxy-L-lysine, converting it to ammonia, inorganic phosphate and 2-aminoadipate semialdehyde	aldehyde dehydrogenase 7 family, member A1; Multifunctional enzyme mediating important protective effects. Metabolizes betaine aldehyde to betaine, an important cellular osmolyte and methyl donor. Protects cells from oxidative stress by metabolizing a number of lipid peroxidation-derived aldehydes. Involved in lysine catabolism	0.961
ALDH7A1	AASS	ENSP00000387123	ENSP00000377040	aldehyde dehydrogenase 7 family, member A1; Multifunctional enzyme mediating important protective effects. Metabolizes betaine aldehyde to betaine, an important cellular osmolyte and methyl donor. Protects cells from oxidative stress by metabolizing a number of lipid peroxidation-derived aldehydes. Involved in lysine catabolism	aminoadipate-semialdehyde synthase; Bifunctional enzyme that catalyzes the first two steps in lysine degradation. The N-terminal and the C-terminal contain lysine-ketoglutarate reductase and saccharopine dehydrogenase activity, respectively	0.964
ALDH7A1	AGXT2L2	ENSP00000387123	ENSP00000310978	aldehyde dehydrogenase 7 family, member A1; Multifunctional enzyme mediating important protective effects. Metabolizes betaine aldehyde to betaine, an important cellular osmolyte and methyl donor. Protects cells from oxidative stress by metabolizing a number of lipid peroxidation-derived aldehydes. Involved in lysine catabolism	alanine-glyoxylate aminotransferase 2-like 2; Catalyzes the pyridoxal-phosphate-dependent breakdown of 5-phosphohydroxy-L-lysine, converting it to ammonia, inorganic phosphate and 2-aminoadipate semialdehyde	0.961
BTD	AASS	ENSP00000306477	ENSP00000377040	biotinidase; Catalytic release of biotin from biocytin, the product of biotin-dependent carboxylases degradation	aminoadipate-semialdehyde synthase; Bifunctional enzyme that catalyzes the first two steps in lysine degradation. The N-terminal and the C-terminal contain lysine-ketoglutarate reductase and saccharopine dehydrogenase activity, respectively	0.823
ENSG00000268412	AASS	ENSP00000472299	ENSP00000377040	Uncharacterized protein	aminoadipate-semialdehyde synthase; Bifunctional enzyme that catalyzes the first two steps in lysine degradation. The N-terminal and the C-terminal contain lysine-ketoglutarate reductase and saccharopine dehydrogenase activity, respectively	0.651

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