node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AAMDC | ACY3 | ENSP00000377078 | ENSP00000255082 | adipogenesis associated, Mth938 domain containing; May play a role in preadipocyte differentiation and adipogenesis (By similarity) | aspartoacylase (aminocyclase) 3; Plays an important role in deacetylating mercapturic acids in kidney proximal tubules (By similarity) | 0.618 |
AAMDC | ALG8 | ENSP00000377078 | ENSP00000299626 | adipogenesis associated, Mth938 domain containing; May play a role in preadipocyte differentiation and adipogenesis (By similarity) | asparagine-linked glycosylation 8, alpha-1,3-glucosyltransferase homolog (S. cerevisiae); Adds the second glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Glc(1)Man(9)GlcNAc(2)-PP-Dol (By similarity) | 0.529 |
AAMDC | CLNS1A | ENSP00000377078 | ENSP00000433919 | adipogenesis associated, Mth938 domain containing; May play a role in preadipocyte differentiation and adipogenesis (By similarity) | chloride channel, nucleotide-sensitive, 1A; The interaction with Sm proteins inhibits their assembly on U RNA and interferes with snRNP biogenesis. Inhibits the binding of survival motor neuron protein (SMN) to Sm proteins. May participate in cellular volume control by activation of a swelling-induced chloride conductance pathway | 0.525 |
AAMDC | CREB1 | ENSP00000377078 | ENSP00000387699 | adipogenesis associated, Mth938 domain containing; May play a role in preadipocyte differentiation and adipogenesis (By similarity) | cAMP responsive element binding protein 1; Phosphorylation-dependent transcription factor that stimulates transcription upon binding to the DNA cAMP response element (CRE), a sequence present in many viral and cellular promoters. Transcription activation is enhanced by the TORC coactivators which act independently of Ser-133 phosphorylation. Involved in different cellular processes including the synchronization of circadian rhythmicity and the differentiation of adipose cells | 0.784 |
AAMDC | CREM | ENSP00000377078 | ENSP00000265372 | adipogenesis associated, Mth938 domain containing; May play a role in preadipocyte differentiation and adipogenesis (By similarity) | cAMP responsive element modulator | 0.658 |
AAMDC | ENSG00000259112 | ENSP00000377078 | ENSP00000432614 | adipogenesis associated, Mth938 domain containing; May play a role in preadipocyte differentiation and adipogenesis (By similarity) | NDUFC2-KCTD14 readthrough; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity) | 0.544 |
AAMDC | INTS4 | ENSP00000377078 | ENSP00000434466 | adipogenesis associated, Mth938 domain containing; May play a role in preadipocyte differentiation and adipogenesis (By similarity) | integrator complex subunit 4; Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3’-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes | 0.614 |
AAMDC | KCTD14 | ENSP00000377078 | ENSP00000316482 | adipogenesis associated, Mth938 domain containing; May play a role in preadipocyte differentiation and adipogenesis (By similarity) | potassium channel tetramerisation domain containing 14 | 0.520 |
AAMDC | NDUFC2 | ENSP00000377078 | ENSP00000281031 | adipogenesis associated, Mth938 domain containing; May play a role in preadipocyte differentiation and adipogenesis (By similarity) | NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 2, 14.5kDa; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity) | 0.532 |
AAMDC | USP35 | ENSP00000377078 | ENSP00000431876 | adipogenesis associated, Mth938 domain containing; May play a role in preadipocyte differentiation and adipogenesis (By similarity) | ubiquitin specific peptidase 35 | 0.735 |
ACY3 | AAMDC | ENSP00000255082 | ENSP00000377078 | aspartoacylase (aminocyclase) 3; Plays an important role in deacetylating mercapturic acids in kidney proximal tubules (By similarity) | adipogenesis associated, Mth938 domain containing; May play a role in preadipocyte differentiation and adipogenesis (By similarity) | 0.618 |
ALG8 | AAMDC | ENSP00000299626 | ENSP00000377078 | asparagine-linked glycosylation 8, alpha-1,3-glucosyltransferase homolog (S. cerevisiae); Adds the second glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Glc(1)Man(9)GlcNAc(2)-PP-Dol (By similarity) | adipogenesis associated, Mth938 domain containing; May play a role in preadipocyte differentiation and adipogenesis (By similarity) | 0.529 |
ALG8 | ENSG00000259112 | ENSP00000299626 | ENSP00000432614 | asparagine-linked glycosylation 8, alpha-1,3-glucosyltransferase homolog (S. cerevisiae); Adds the second glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Glc(1)Man(9)GlcNAc(2)-PP-Dol (By similarity) | NDUFC2-KCTD14 readthrough; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity) | 0.715 |
ALG8 | INTS4 | ENSP00000299626 | ENSP00000434466 | asparagine-linked glycosylation 8, alpha-1,3-glucosyltransferase homolog (S. cerevisiae); Adds the second glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Glc(1)Man(9)GlcNAc(2)-PP-Dol (By similarity) | integrator complex subunit 4; Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3’-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes | 0.444 |
ALG8 | KCTD14 | ENSP00000299626 | ENSP00000316482 | asparagine-linked glycosylation 8, alpha-1,3-glucosyltransferase homolog (S. cerevisiae); Adds the second glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Glc(1)Man(9)GlcNAc(2)-PP-Dol (By similarity) | potassium channel tetramerisation domain containing 14 | 0.542 |
ALG8 | NDUFC2 | ENSP00000299626 | ENSP00000281031 | asparagine-linked glycosylation 8, alpha-1,3-glucosyltransferase homolog (S. cerevisiae); Adds the second glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Glc(1)Man(9)GlcNAc(2)-PP-Dol (By similarity) | NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 2, 14.5kDa; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity) | 0.695 |
ALG8 | USP35 | ENSP00000299626 | ENSP00000431876 | asparagine-linked glycosylation 8, alpha-1,3-glucosyltransferase homolog (S. cerevisiae); Adds the second glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Glc(1)Man(9)GlcNAc(2)-PP-Dol (By similarity) | ubiquitin specific peptidase 35 | 0.607 |
CLNS1A | AAMDC | ENSP00000433919 | ENSP00000377078 | chloride channel, nucleotide-sensitive, 1A; The interaction with Sm proteins inhibits their assembly on U RNA and interferes with snRNP biogenesis. Inhibits the binding of survival motor neuron protein (SMN) to Sm proteins. May participate in cellular volume control by activation of a swelling-induced chloride conductance pathway | adipogenesis associated, Mth938 domain containing; May play a role in preadipocyte differentiation and adipogenesis (By similarity) | 0.525 |
CLNS1A | INTS4 | ENSP00000433919 | ENSP00000434466 | chloride channel, nucleotide-sensitive, 1A; The interaction with Sm proteins inhibits their assembly on U RNA and interferes with snRNP biogenesis. Inhibits the binding of survival motor neuron protein (SMN) to Sm proteins. May participate in cellular volume control by activation of a swelling-induced chloride conductance pathway | integrator complex subunit 4; Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3’-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes | 0.418 |
CLNS1A | KCTD14 | ENSP00000433919 | ENSP00000316482 | chloride channel, nucleotide-sensitive, 1A; The interaction with Sm proteins inhibits their assembly on U RNA and interferes with snRNP biogenesis. Inhibits the binding of survival motor neuron protein (SMN) to Sm proteins. May participate in cellular volume control by activation of a swelling-induced chloride conductance pathway | potassium channel tetramerisation domain containing 14 | 0.542 |