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STRINGSTRING
CLNS1A CLNS1A KCTD14 KCTD14 INTS4 INTS4 ENSG00000259112 ENSG00000259112 USP35 USP35 CREB1 CREB1 AAMDC AAMDC ALG8 ALG8 CREM CREM NDUFC2 NDUFC2 ACY3 ACY3
"AAMDC" - adipogenesis associated, Mth938 domain containing in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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protein of unknown 3D structure
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some 3D structure is known or predicted
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query proteins and first shell of interactors
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white nodes:
second shell of interactors
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experimentally determined
Predicted Interactions
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protein homology
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[Homology]
Score
AAMDCadipogenesis associated, Mth938 domain containing; May play a role in preadipocyte differentiation and adipogenesis (By similarity) (122 aa)    
Predicted Functional Partners:
CREB1
cAMP responsive element binding protein 1; Phosphorylation-dependent transcription factor that stimulates transcription upon binding to the DNA cAMP response element (CRE), a sequence present in many viral and cellular promoters. Transcription activation is enhanced by the TORC coactivators which act independently of Ser-133 phosphorylation. Involved in different cellular processes including the synchronization of circadian rhythmicity and the differentiation of adipose cells (341 aa)
            score_image   0.784
USP35
ubiquitin specific peptidase 35 (1018 aa)
            score_image   0.735
CREM
cAMP responsive element modulator (300 aa)
            score_image   0.658
ACY3
aspartoacylase (aminocyclase) 3; Plays an important role in deacetylating mercapturic acids in kidney proximal tubules (By similarity) (319 aa)
        score_image       0.618
INTS4
integrator complex subunit 4; Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3’-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes (963 aa)
            score_image   0.614
ENSG00000259112
NDUFC2-KCTD14 readthrough; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity) (114 aa)
            score_image   0.544
NDUFC2
NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 2, 14.5kDa; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity) (119 aa)
            score_image   0.532
ALG8
asparagine-linked glycosylation 8, alpha-1,3-glucosyltransferase homolog (S. cerevisiae); Adds the second glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Glc(1)Man(9)GlcNAc(2)-PP-Dol (By similarity) (526 aa)
            score_image   0.529
CLNS1A
chloride channel, nucleotide-sensitive, 1A; The interaction with Sm proteins inhibits their assembly on U RNA and interferes with snRNP biogenesis. Inhibits the binding of survival motor neuron protein (SMN) to Sm proteins. May participate in cellular volume control by activation of a swelling-induced chloride conductance pathway (237 aa)
            score_image   0.525
KCTD14
potassium channel tetramerisation domain containing 14 (255 aa)
            score_image   0.520
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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