node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACIN1 | RNPS1 | ENSP00000262710 | ENSP00000301730 | apoptotic chromatin condensation inducer 1; Component of a splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of a few core proteins and several more peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Induces apoptotic chromatin condensation after activation by CASP3. Regulates cyclin A1, but not cyclin A2, expression in leukemia cells | RNA binding protein S1, serine-rich domain | 0.999 |
ACIN1 | SRPK2 | ENSP00000262710 | ENSP00000377262 | apoptotic chromatin condensation inducer 1; Component of a splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of a few core proteins and several more peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Induces apoptotic chromatin condensation after activation by CASP3. Regulates cyclin A1, but not cyclin A2, expression in leukemia cells | SRSF protein kinase 2; Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains and is involved in the phosphorylation of SR splicing factors and the regulation of splicing. Promotes neuronal apoptosis by up-regulating cyclin-D1 (CCND1) expression. This is done by the phosphorylation of SRSF2, leading to the suppression of p53/TP53 phosphorylation thereby relieving the repressive effect of p53/TP53 on cyclin-D1 (CCND1) expression. Phosphorylates ACIN1, and [...] | 0.974 |
DDX23 | PRPF38A | ENSP00000310723 | ENSP00000257181 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 23; Involved in pre-mRNA splicing and its phosphorylated form (by SRPK2) is required for spliceosomal B complex formation | PRP38 pre-mRNA processing factor 38 (yeast) domain containing A; May be required for pre-mRNA splicing (Potential) | 0.448 |
DDX23 | RNPS1 | ENSP00000310723 | ENSP00000301730 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 23; Involved in pre-mRNA splicing and its phosphorylated form (by SRPK2) is required for spliceosomal B complex formation | RNA binding protein S1, serine-rich domain | 0.926 |
DDX23 | SNRNP70 | ENSP00000310723 | ENSP00000472998 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 23; Involved in pre-mRNA splicing and its phosphorylated form (by SRPK2) is required for spliceosomal B complex formation | small nuclear ribonucleoprotein 70kDa (U1) | 0.961 |
DDX23 | SRPK2 | ENSP00000310723 | ENSP00000377262 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 23; Involved in pre-mRNA splicing and its phosphorylated form (by SRPK2) is required for spliceosomal B complex formation | SRSF protein kinase 2; Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains and is involved in the phosphorylation of SR splicing factors and the regulation of splicing. Promotes neuronal apoptosis by up-regulating cyclin-D1 (CCND1) expression. This is done by the phosphorylation of SRSF2, leading to the suppression of p53/TP53 phosphorylation thereby relieving the repressive effect of p53/TP53 on cyclin-D1 (CCND1) expression. Phosphorylates ACIN1, and [...] | 0.972 |
DDX23 | SRSF1 | ENSP00000310723 | ENSP00000258962 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 23; Involved in pre-mRNA splicing and its phosphorylated form (by SRPK2) is required for spliceosomal B complex formation | serine/arginine-rich splicing factor 1; Plays a role in preventing exon skipping, ensuring the accuracy of splicing and regulating alternative splicing. Interacts with other spliceosomal components, via the RS domains, to form a bridge between the 5’- and 3’-splice site binding components, U1 snRNP and U2AF. Can stimulate binding of U1 snRNP to a 5’-splice site-containing pre-mRNA. Binds to purine-rich RNA sequences, either the octamer, 5’-RGAAGAAC-3’ (r=A or G) or the decamers, AGGACAGAGC/AGGACGAAGC. Binds preferentially to the 5’- CGAGGCG-3’ motif in vitro. Three copies of the octame [...] | 0.944 |
DDX23 | SRSF2 | ENSP00000310723 | ENSP00000353089 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 23; Involved in pre-mRNA splicing and its phosphorylated form (by SRPK2) is required for spliceosomal B complex formation | serine/arginine-rich splicing factor 2; Necessary for the splicing of pre-mRNA. It is required for formation of the earliest ATP-dependent splicing complex and interacts with spliceosomal components bound to both the 5’- and 3’-splice sites during spliceosome assembly. It also is required for ATP-dependent interactions of both U1 and U2 snRNPs with pre- mRNA. Interacts with other spliceosomal components, via the RS domains, to form a bridge between the 5’- and 3’-splice site binding components, U1 snRNP and U2AF. Binds to purine-rich RNA sequences, either 5’-AGSAGAGTA-3’ (S=C or G) or [...] | 0.923 |
DDX23 | SRSF5 | ENSP00000310723 | ENSP00000377892 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 23; Involved in pre-mRNA splicing and its phosphorylated form (by SRPK2) is required for spliceosomal B complex formation | serine/arginine-rich splicing factor 5; Plays a role in constitutive splicing and can modulate the selection of alternative splice sites | 0.950 |
DDX23 | SRSF6 | ENSP00000310723 | ENSP00000244020 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 23; Involved in pre-mRNA splicing and its phosphorylated form (by SRPK2) is required for spliceosomal B complex formation | serine/arginine-rich splicing factor 6; Plays a role in constitutive splicing and can modulate the selection of alternative splice sites. Represses the splicing of MAPT/Tau exon 10 | 0.914 |
DDX23 | U2AF1 | ENSP00000310723 | ENSP00000291552 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 23; Involved in pre-mRNA splicing and its phosphorylated form (by SRPK2) is required for spliceosomal B complex formation | U2 small nuclear RNA auxiliary factor 1; Plays a critical role in both constitutive and enhancer- dependent splicing by mediating protein-protein interactions and protein-RNA interactions required for accurate 3’-splice site selection. Recruits U2 snRNP to the branch point. Directly mediates interactions between U2AF2 and proteins bound to the enhancers and thus may function as a bridge between U2AF2 and the enhancer complex to recruit it to the adjacent intron | 0.927 |
PRPF38A | DDX23 | ENSP00000257181 | ENSP00000310723 | PRP38 pre-mRNA processing factor 38 (yeast) domain containing A; May be required for pre-mRNA splicing (Potential) | DEAD (Asp-Glu-Ala-Asp) box polypeptide 23; Involved in pre-mRNA splicing and its phosphorylated form (by SRPK2) is required for spliceosomal B complex formation | 0.448 |
PRPF38A | RNPS1 | ENSP00000257181 | ENSP00000301730 | PRP38 pre-mRNA processing factor 38 (yeast) domain containing A; May be required for pre-mRNA splicing (Potential) | RNA binding protein S1, serine-rich domain | 0.777 |
PRPF38A | SRPK2 | ENSP00000257181 | ENSP00000377262 | PRP38 pre-mRNA processing factor 38 (yeast) domain containing A; May be required for pre-mRNA splicing (Potential) | SRSF protein kinase 2; Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains and is involved in the phosphorylation of SR splicing factors and the regulation of splicing. Promotes neuronal apoptosis by up-regulating cyclin-D1 (CCND1) expression. This is done by the phosphorylation of SRSF2, leading to the suppression of p53/TP53 phosphorylation thereby relieving the repressive effect of p53/TP53 on cyclin-D1 (CCND1) expression. Phosphorylates ACIN1, and [...] | 0.960 |
PRPF38A | U2AF1 | ENSP00000257181 | ENSP00000291552 | PRP38 pre-mRNA processing factor 38 (yeast) domain containing A; May be required for pre-mRNA splicing (Potential) | U2 small nuclear RNA auxiliary factor 1; Plays a critical role in both constitutive and enhancer- dependent splicing by mediating protein-protein interactions and protein-RNA interactions required for accurate 3’-splice site selection. Recruits U2 snRNP to the branch point. Directly mediates interactions between U2AF2 and proteins bound to the enhancers and thus may function as a bridge between U2AF2 and the enhancer complex to recruit it to the adjacent intron | 0.719 |
RNPS1 | ACIN1 | ENSP00000301730 | ENSP00000262710 | RNA binding protein S1, serine-rich domain | apoptotic chromatin condensation inducer 1; Component of a splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of a few core proteins and several more peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Induces apoptotic chromatin condensation after activation by CASP3. Regulates cyclin A1, but not cyclin A2, expression in leukemia cells | 0.999 |
RNPS1 | DDX23 | ENSP00000301730 | ENSP00000310723 | RNA binding protein S1, serine-rich domain | DEAD (Asp-Glu-Ala-Asp) box polypeptide 23; Involved in pre-mRNA splicing and its phosphorylated form (by SRPK2) is required for spliceosomal B complex formation | 0.926 |
RNPS1 | PRPF38A | ENSP00000301730 | ENSP00000257181 | RNA binding protein S1, serine-rich domain | PRP38 pre-mRNA processing factor 38 (yeast) domain containing A; May be required for pre-mRNA splicing (Potential) | 0.777 |
RNPS1 | SNRNP70 | ENSP00000301730 | ENSP00000472998 | RNA binding protein S1, serine-rich domain | small nuclear ribonucleoprotein 70kDa (U1) | 0.956 |
RNPS1 | SRPK2 | ENSP00000301730 | ENSP00000377262 | RNA binding protein S1, serine-rich domain | SRSF protein kinase 2; Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains and is involved in the phosphorylation of SR splicing factors and the regulation of splicing. Promotes neuronal apoptosis by up-regulating cyclin-D1 (CCND1) expression. This is done by the phosphorylation of SRSF2, leading to the suppression of p53/TP53 phosphorylation thereby relieving the repressive effect of p53/TP53 on cyclin-D1 (CCND1) expression. Phosphorylates ACIN1, and [...] | 0.958 |