PC protein (Homo sapiens) - STRING network view

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PC

pyruvate carboxylase; Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. Catalyzes in a tissue specific manner, the initial reactions of glucose (liver, kidney) and lipid (adipose tissue, liver, brain) synthesis from pyruvate (1178 aa)

Predicted Functional Partners:

HLCS

0.991

CS

0.985

PCK2

0.983

MDH2

0.979

PKM

0.975

PRKCDBP

0.972

PPT2

0.972

ME3

0.971

ME1

0.971

PCK1

0.968

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CS	MDH2	ENSP00000342056	ENSP00000327070	citrate synthase	malate dehydrogenase 2, NAD (mitochondrial)	0.996
CS	ME1	ENSP00000342056	ENSP00000358719	citrate synthase	malic enzyme 1, NADP(+)-dependent, cytosolic	0.895
CS	ME3	ENSP00000342056	ENSP00000352657	citrate synthase	malic enzyme 3, NADP(+)-dependent, mitochondrial	0.904
CS	PC	ENSP00000342056	ENSP00000377527	citrate synthase	pyruvate carboxylase; Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. Catalyzes in a tissue specific manner, the initial reactions of glucose (liver, kidney) and lipid (adipose tissue, liver, brain) synthesis from pyruvate	0.985
CS	PCK1	ENSP00000342056	ENSP00000319814	citrate synthase	phosphoenolpyruvate carboxykinase 1 (soluble); Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle	0.924
CS	PCK2	ENSP00000342056	ENSP00000216780	citrate synthase	phosphoenolpyruvate carboxykinase 2 (mitochondrial); Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle (By similarity)	0.531
CS	PKM	ENSP00000342056	ENSP00000320171	citrate synthase	pyruvate kinase, muscle	0.682
HLCS	PC	ENSP00000338387	ENSP00000377527	holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase); Post-translational modification of specific protein by attachment of biotin. Acts on various carboxylases such as acetyl- CoA-carboxylase, pyruvate carboxylase, propionyl CoA carboxylase, and 3-methylcrotonyl CoA carboxylase	pyruvate carboxylase; Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. Catalyzes in a tissue specific manner, the initial reactions of glucose (liver, kidney) and lipid (adipose tissue, liver, brain) synthesis from pyruvate	0.991
MDH2	CS	ENSP00000327070	ENSP00000342056	malate dehydrogenase 2, NAD (mitochondrial)	citrate synthase	0.996
MDH2	ME1	ENSP00000327070	ENSP00000358719	malate dehydrogenase 2, NAD (mitochondrial)	malic enzyme 1, NADP(+)-dependent, cytosolic	0.963
MDH2	ME3	ENSP00000327070	ENSP00000352657	malate dehydrogenase 2, NAD (mitochondrial)	malic enzyme 3, NADP(+)-dependent, mitochondrial	0.967
MDH2	PC	ENSP00000327070	ENSP00000377527	malate dehydrogenase 2, NAD (mitochondrial)	pyruvate carboxylase; Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. Catalyzes in a tissue specific manner, the initial reactions of glucose (liver, kidney) and lipid (adipose tissue, liver, brain) synthesis from pyruvate	0.979
MDH2	PCK1	ENSP00000327070	ENSP00000319814	malate dehydrogenase 2, NAD (mitochondrial)	phosphoenolpyruvate carboxykinase 1 (soluble); Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle	0.931
MDH2	PKM	ENSP00000327070	ENSP00000320171	malate dehydrogenase 2, NAD (mitochondrial)	pyruvate kinase, muscle	0.907
ME1	CS	ENSP00000358719	ENSP00000342056	malic enzyme 1, NADP(+)-dependent, cytosolic	citrate synthase	0.895
ME1	MDH2	ENSP00000358719	ENSP00000327070	malic enzyme 1, NADP(+)-dependent, cytosolic	malate dehydrogenase 2, NAD (mitochondrial)	0.963
ME1	PC	ENSP00000358719	ENSP00000377527	malic enzyme 1, NADP(+)-dependent, cytosolic	pyruvate carboxylase; Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. Catalyzes in a tissue specific manner, the initial reactions of glucose (liver, kidney) and lipid (adipose tissue, liver, brain) synthesis from pyruvate	0.971
ME1	PCK1	ENSP00000358719	ENSP00000319814	malic enzyme 1, NADP(+)-dependent, cytosolic	phosphoenolpyruvate carboxykinase 1 (soluble); Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle	0.486
ME1	PCK2	ENSP00000358719	ENSP00000216780	malic enzyme 1, NADP(+)-dependent, cytosolic	phosphoenolpyruvate carboxykinase 2 (mitochondrial); Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle (By similarity)	0.507
ME1	PKM	ENSP00000358719	ENSP00000320171	malic enzyme 1, NADP(+)-dependent, cytosolic	pyruvate kinase, muscle	0.977

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