node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABCB11 | ALB | ENSP00000263817 | ENSP00000295897 | ATP-binding cassette, sub-family B (MDR/TAP), member 11; Involved in the ATP-dependent secretion of bile salts into the canaliculus of hepatocytes | albumin | 0.412 |
ABCB11 | FABP6 | ENSP00000263817 | ENSP00000377549 | ATP-binding cassette, sub-family B (MDR/TAP), member 11; Involved in the ATP-dependent secretion of bile salts into the canaliculus of hepatocytes | fatty acid binding protein 6, ileal; Ileal protein which stimulates gastric acid and pepsinogen secretion. Seems to be able to bind to bile salts and bilirubins. Isoform 2 is essential for the survival of colon cancer cells to bile acid-induced apoptosis | 0.757 |
ABCB11 | HNF4A | ENSP00000263817 | ENSP00000312987 | ATP-binding cassette, sub-family B (MDR/TAP), member 11; Involved in the ATP-dependent secretion of bile salts into the canaliculus of hepatocytes | hepatocyte nuclear factor 4, alpha | 0.472 |
ABCB11 | NR1H4 | ENSP00000263817 | ENSP00000447149 | ATP-binding cassette, sub-family B (MDR/TAP), member 11; Involved in the ATP-dependent secretion of bile salts into the canaliculus of hepatocytes | nuclear receptor subfamily 1, group H, member 4; Ligand-activated transcription factor. Receptor for bile acids such as chenodeoxycholic acid, lithocholic acid and deoxycholic acid. Represses the transcription of the cholesterol 7-alpha-hydroxylase gene (CYP7A1) through the induction of NR0B2 or FGF19 expression, via two distinct mechanisms. Activates the intestinal bile acid-binding protein (IBABP). Activates the transcription of bile salt export pump ABCB11 by directly recruiting histone methyltransferase CARM1 to this locus | 0.962 |
ABCB11 | SLC10A1 | ENSP00000263817 | ENSP00000216540 | ATP-binding cassette, sub-family B (MDR/TAP), member 11; Involved in the ATP-dependent secretion of bile salts into the canaliculus of hepatocytes | solute carrier family 10 (sodium/bile acid cotransporter family), member 1; The hepatic sodium/bile acid uptake system exhibits broad substrate specificity and transports various non-bile acid organic compounds as well. It is strictly dependent on the extracellular presence of sodium | 0.917 |
ABCB11 | SLC10A2 | ENSP00000263817 | ENSP00000245312 | ATP-binding cassette, sub-family B (MDR/TAP), member 11; Involved in the ATP-dependent secretion of bile salts into the canaliculus of hepatocytes | solute carrier family 10 (sodium/bile acid cotransporter family), member 2; Plays a critical role in the sodium-dependent reabsorption of bile acids from the lumen of the small intestine. Plays a key role in cholesterol metabolism | 0.739 |
ABCB11 | SLCO1A2 | ENSP00000263817 | ENSP00000305974 | ATP-binding cassette, sub-family B (MDR/TAP), member 11; Involved in the ATP-dependent secretion of bile salts into the canaliculus of hepatocytes | solute carrier organic anion transporter family, member 1A2; Mediates the Na(+)-independent transport of organic anions such as sulfobromophthalein (BSP) and conjugated (taurocholate) and unconjugated (cholate) bile acids (By similarity). Selectively inhibited by the grapefruit juice component naringin | 0.813 |
ABCB11 | SLCO1B1 | ENSP00000263817 | ENSP00000256958 | ATP-binding cassette, sub-family B (MDR/TAP), member 11; Involved in the ATP-dependent secretion of bile salts into the canaliculus of hepatocytes | solute carrier organic anion transporter family, member 1B1; Mediates the Na(+)-independent uptake of organic anions such as pravastatin, taurocholate, methotrexate, dehydroepiandrosterone sulfate, 17-beta-glucuronosyl estradiol, estrone sulfate, prostaglandin E2, thromboxane B2, leukotriene C3, leukotriene E4, thyroxine and triiodothyronine. Involved in the clearance of bile acids and organic anions from the liver | 0.851 |
ABCB11 | SLCO1B3 | ENSP00000263817 | ENSP00000261196 | ATP-binding cassette, sub-family B (MDR/TAP), member 11; Involved in the ATP-dependent secretion of bile salts into the canaliculus of hepatocytes | solute carrier organic anion transporter family, member 1B3; Mediates the Na(+)-independent uptake of organic anions such as 17-beta-glucuronosyl estradiol, taurocholate, triiodothyronine (T3), leukotriene C4, dehydroepiandrosterone sulfate (DHEAS), methotrexate and sulfobromophthalein (BSP). Involved in the clearance of bile acids and organic anions from the liver | 0.782 |
ABCC3 | ALB | ENSP00000285238 | ENSP00000295897 | ATP-binding cassette, sub-family C (CFTR/MRP), member 3 | albumin | 0.925 |
ABCC3 | FABP6 | ENSP00000285238 | ENSP00000377549 | ATP-binding cassette, sub-family C (CFTR/MRP), member 3 | fatty acid binding protein 6, ileal; Ileal protein which stimulates gastric acid and pepsinogen secretion. Seems to be able to bind to bile salts and bilirubins. Isoform 2 is essential for the survival of colon cancer cells to bile acid-induced apoptosis | 0.933 |
ABCC3 | NR1H4 | ENSP00000285238 | ENSP00000447149 | ATP-binding cassette, sub-family C (CFTR/MRP), member 3 | nuclear receptor subfamily 1, group H, member 4; Ligand-activated transcription factor. Receptor for bile acids such as chenodeoxycholic acid, lithocholic acid and deoxycholic acid. Represses the transcription of the cholesterol 7-alpha-hydroxylase gene (CYP7A1) through the induction of NR0B2 or FGF19 expression, via two distinct mechanisms. Activates the intestinal bile acid-binding protein (IBABP). Activates the transcription of bile salt export pump ABCB11 by directly recruiting histone methyltransferase CARM1 to this locus | 0.533 |
ABCC3 | SLC10A1 | ENSP00000285238 | ENSP00000216540 | ATP-binding cassette, sub-family C (CFTR/MRP), member 3 | solute carrier family 10 (sodium/bile acid cotransporter family), member 1; The hepatic sodium/bile acid uptake system exhibits broad substrate specificity and transports various non-bile acid organic compounds as well. It is strictly dependent on the extracellular presence of sodium | 0.975 |
ABCC3 | SLC10A2 | ENSP00000285238 | ENSP00000245312 | ATP-binding cassette, sub-family C (CFTR/MRP), member 3 | solute carrier family 10 (sodium/bile acid cotransporter family), member 2; Plays a critical role in the sodium-dependent reabsorption of bile acids from the lumen of the small intestine. Plays a key role in cholesterol metabolism | 0.957 |
ABCC3 | SLCO1A2 | ENSP00000285238 | ENSP00000305974 | ATP-binding cassette, sub-family C (CFTR/MRP), member 3 | solute carrier organic anion transporter family, member 1A2; Mediates the Na(+)-independent transport of organic anions such as sulfobromophthalein (BSP) and conjugated (taurocholate) and unconjugated (cholate) bile acids (By similarity). Selectively inhibited by the grapefruit juice component naringin | 0.973 |
ABCC3 | SLCO1B1 | ENSP00000285238 | ENSP00000256958 | ATP-binding cassette, sub-family C (CFTR/MRP), member 3 | solute carrier organic anion transporter family, member 1B1; Mediates the Na(+)-independent uptake of organic anions such as pravastatin, taurocholate, methotrexate, dehydroepiandrosterone sulfate, 17-beta-glucuronosyl estradiol, estrone sulfate, prostaglandin E2, thromboxane B2, leukotriene C3, leukotriene E4, thyroxine and triiodothyronine. Involved in the clearance of bile acids and organic anions from the liver | 0.977 |
ABCC3 | SLCO1B3 | ENSP00000285238 | ENSP00000261196 | ATP-binding cassette, sub-family C (CFTR/MRP), member 3 | solute carrier organic anion transporter family, member 1B3; Mediates the Na(+)-independent uptake of organic anions such as 17-beta-glucuronosyl estradiol, taurocholate, triiodothyronine (T3), leukotriene C4, dehydroepiandrosterone sulfate (DHEAS), methotrexate and sulfobromophthalein (BSP). Involved in the clearance of bile acids and organic anions from the liver | 0.974 |
ALB | ABCB11 | ENSP00000295897 | ENSP00000263817 | albumin | ATP-binding cassette, sub-family B (MDR/TAP), member 11; Involved in the ATP-dependent secretion of bile salts into the canaliculus of hepatocytes | 0.412 |
ALB | ABCC3 | ENSP00000295897 | ENSP00000285238 | albumin | ATP-binding cassette, sub-family C (CFTR/MRP), member 3 | 0.925 |
ALB | FABP6 | ENSP00000295897 | ENSP00000377549 | albumin | fatty acid binding protein 6, ileal; Ileal protein which stimulates gastric acid and pepsinogen secretion. Seems to be able to bind to bile salts and bilirubins. Isoform 2 is essential for the survival of colon cancer cells to bile acid-induced apoptosis | 0.928 |