MTHFD2 protein (Homo sapiens) - STRING network view

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MTHFD2

methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase (350 aa)

Predicted Functional Partners:

SHMT1

0.988

SHMT2

0.986

GART

0.984

AMT

0.984

MTHFD1L

0.967

MTHFR

0.961

ATIC

0.960

FTCD

0.960

MTHFD1

0.959

ALDH1L1

0.956

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ALDH1L1	AMT	ENSP00000377083	ENSP00000273588	aldehyde dehydrogenase 1 family, member L1	aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine (By similarity)	0.923
ALDH1L1	ATIC	ENSP00000377083	ENSP00000236959	aldehyde dehydrogenase 1 family, member L1	5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase; Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis	0.410
ALDH1L1	FTCD	ENSP00000377083	ENSP00000291670	aldehyde dehydrogenase 1 family, member L1	formiminotransferase cyclodeaminase; Folate-dependent enzyme, that displays both transferase and deaminase activity. Serves to channel one-carbon units from formiminoglutamate to the folate pool	0.934
ALDH1L1	GART	ENSP00000377083	ENSP00000371236	aldehyde dehydrogenase 1 family, member L1	phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase	0.609
ALDH1L1	MTHFD1	ENSP00000377083	ENSP00000450560	aldehyde dehydrogenase 1 family, member L1	methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase	0.974
ALDH1L1	MTHFD1L	ENSP00000377083	ENSP00000356290	aldehyde dehydrogenase 1 family, member L1	methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like; May provide the missing metabolic reaction required to link the mitochondria and the cytoplasm in the mammalian model of one-carbon folate metabolism in embryonic an transformed cells complementing thus the enzymatic activities of MTHFD2 (By similarity)	0.755
ALDH1L1	MTHFD2	ENSP00000377083	ENSP00000377617	aldehyde dehydrogenase 1 family, member L1	methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase	0.956
ALDH1L1	MTHFR	ENSP00000377083	ENSP00000365775	aldehyde dehydrogenase 1 family, member L1	methylenetetrahydrofolate reductase (NAD(P)H); Catalyzes the conversion of 5,10- methylenetetrahydrofolate to 5-methyltetrahydrofolate, a co- substrate for homocysteine remethylation to methionine	0.449
ALDH1L1	SHMT1	ENSP00000377083	ENSP00000318868	aldehyde dehydrogenase 1 family, member L1	serine hydroxymethyltransferase 1 (soluble); Interconversion of serine and glycine (By similarity)	0.956
ALDH1L1	SHMT2	ENSP00000377083	ENSP00000333667	aldehyde dehydrogenase 1 family, member L1	serine hydroxymethyltransferase 2 (mitochondrial); Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Required to prevent uracil accumulation in mtDNA. Interconversion of serine and glycine. Associates with mitochondrial DNA	0.948
AMT	ALDH1L1	ENSP00000273588	ENSP00000377083	aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine (By similarity)	aldehyde dehydrogenase 1 family, member L1	0.923
AMT	ATIC	ENSP00000273588	ENSP00000236959	aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine (By similarity)	5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase; Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis	0.941
AMT	FTCD	ENSP00000273588	ENSP00000291670	aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine (By similarity)	formiminotransferase cyclodeaminase; Folate-dependent enzyme, that displays both transferase and deaminase activity. Serves to channel one-carbon units from formiminoglutamate to the folate pool	0.913
AMT	MTHFD1	ENSP00000273588	ENSP00000450560	aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine (By similarity)	methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase	0.981
AMT	MTHFD1L	ENSP00000273588	ENSP00000356290	aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine (By similarity)	methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like; May provide the missing metabolic reaction required to link the mitochondria and the cytoplasm in the mammalian model of one-carbon folate metabolism in embryonic an transformed cells complementing thus the enzymatic activities of MTHFD2 (By similarity)	0.983
AMT	MTHFD2	ENSP00000273588	ENSP00000377617	aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine (By similarity)	methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase	0.984
AMT	MTHFR	ENSP00000273588	ENSP00000365775	aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine (By similarity)	methylenetetrahydrofolate reductase (NAD(P)H); Catalyzes the conversion of 5,10- methylenetetrahydrofolate to 5-methyltetrahydrofolate, a co- substrate for homocysteine remethylation to methionine	0.930
AMT	SHMT1	ENSP00000273588	ENSP00000318868	aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine (By similarity)	serine hydroxymethyltransferase 1 (soluble); Interconversion of serine and glycine (By similarity)	0.985
AMT	SHMT2	ENSP00000273588	ENSP00000333667	aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine (By similarity)	serine hydroxymethyltransferase 2 (mitochondrial); Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Required to prevent uracil accumulation in mtDNA. Interconversion of serine and glycine. Associates with mitochondrial DNA	0.988
ATIC	ALDH1L1	ENSP00000236959	ENSP00000377083	5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase; Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis	aldehyde dehydrogenase 1 family, member L1	0.410

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