node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CCZ1 | GAPVD1 | ENSP00000325681 | ENSP00000377665 | CCZ1 vacuolar protein trafficking and biogenesis associated homolog (S. cerevisiae) | GTPase activating protein and VPS9 domains 1 | 0.610 |
CCZ1 | MON1A | ENSP00000325681 | ENSP00000296473 | CCZ1 vacuolar protein trafficking and biogenesis associated homolog (S. cerevisiae) | MON1 homolog A (yeast); Plays an important in membrane trafficking through the secretory apparatus. Not involved in endocytic trafficking to lysosomes (By similarity) | 0.863 |
CCZ1 | MON1B | ENSP00000325681 | ENSP00000248248 | CCZ1 vacuolar protein trafficking and biogenesis associated homolog (S. cerevisiae) | MON1 homolog B (yeast) | 0.862 |
CCZ1 | RAB5A | ENSP00000325681 | ENSP00000273047 | CCZ1 vacuolar protein trafficking and biogenesis associated homolog (S. cerevisiae) | RAB5A, member RAS oncogene family; Required for the fusion of plasma membranes and early endosomes. Contributes to the regulation of filopodia extension | 0.610 |
CCZ1 | UBC | ENSP00000325681 | ENSP00000344818 | CCZ1 vacuolar protein trafficking and biogenesis associated homolog (S. cerevisiae) | ubiquitin C | 0.483 |
CCZ1B | GAPVD1 | ENSP00000314544 | ENSP00000377665 | CCZ1 vacuolar protein trafficking and biogenesis associated homolog B (S. cerevisiae) | GTPase activating protein and VPS9 domains 1 | 0.610 |
CCZ1B | MON1A | ENSP00000314544 | ENSP00000296473 | CCZ1 vacuolar protein trafficking and biogenesis associated homolog B (S. cerevisiae) | MON1 homolog A (yeast); Plays an important in membrane trafficking through the secretory apparatus. Not involved in endocytic trafficking to lysosomes (By similarity) | 0.863 |
CCZ1B | MON1B | ENSP00000314544 | ENSP00000248248 | CCZ1 vacuolar protein trafficking and biogenesis associated homolog B (S. cerevisiae) | MON1 homolog B (yeast) | 0.862 |
CCZ1B | RAB5A | ENSP00000314544 | ENSP00000273047 | CCZ1 vacuolar protein trafficking and biogenesis associated homolog B (S. cerevisiae) | RAB5A, member RAS oncogene family; Required for the fusion of plasma membranes and early endosomes. Contributes to the regulation of filopodia extension | 0.610 |
CCZ1B | UBC | ENSP00000314544 | ENSP00000344818 | CCZ1 vacuolar protein trafficking and biogenesis associated homolog B (S. cerevisiae) | ubiquitin C | 0.854 |
COPS2 | GAPVD1 | ENSP00000299259 | ENSP00000377665 | COP9 constitutive photomorphogenic homolog subunit 2 (Arabidopsis); Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its a [...] | GTPase activating protein and VPS9 domains 1 | 0.644 |
COPS2 | UBC | ENSP00000299259 | ENSP00000344818 | COP9 constitutive photomorphogenic homolog subunit 2 (Arabidopsis); Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its a [...] | ubiquitin C | 0.981 |
GAPVD1 | CCZ1 | ENSP00000377665 | ENSP00000325681 | GTPase activating protein and VPS9 domains 1 | CCZ1 vacuolar protein trafficking and biogenesis associated homolog (S. cerevisiae) | 0.610 |
GAPVD1 | CCZ1B | ENSP00000377665 | ENSP00000314544 | GTPase activating protein and VPS9 domains 1 | CCZ1 vacuolar protein trafficking and biogenesis associated homolog B (S. cerevisiae) | 0.610 |
GAPVD1 | COPS2 | ENSP00000377665 | ENSP00000299259 | GTPase activating protein and VPS9 domains 1 | COP9 constitutive photomorphogenic homolog subunit 2 (Arabidopsis); Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its a [...] | 0.644 |
GAPVD1 | MON1A | ENSP00000377665 | ENSP00000296473 | GTPase activating protein and VPS9 domains 1 | MON1 homolog A (yeast); Plays an important in membrane trafficking through the secretory apparatus. Not involved in endocytic trafficking to lysosomes (By similarity) | 0.609 |
GAPVD1 | MON1B | ENSP00000377665 | ENSP00000248248 | GTPase activating protein and VPS9 domains 1 | MON1 homolog B (yeast) | 0.610 |
GAPVD1 | NGFR | ENSP00000377665 | ENSP00000172229 | GTPase activating protein and VPS9 domains 1 | nerve growth factor receptor; Plays a role in the regulation of the translocation of GLUT4 to the cell surface in adipocytes and skeletal muscle cells in response to insulin, probably by regulating RAB31 activity, and thereby contributes to the regulation of insulin-dependent glucose uptake (By similarity). Low affinity receptor which can bind to NGF, BDNF, NT-3, and NT-4. Can mediate cell survival as well as cell death of neural cells | 0.800 |
GAPVD1 | NXF1 | ENSP00000377665 | ENSP00000294172 | GTPase activating protein and VPS9 domains 1 | nuclear RNA export factor 1; Involved in the nuclear export of mRNA species bearing retroviral constitutive transport elements (CTE) and in the export of mRNA from the nucleus to the cytoplasm. The NXF1-NXT1 heterodimer is involved in the export of HSP70 mRNA in conjunction with ALYREF/THOC4 and THOC5 | 0.610 |
GAPVD1 | RAB31 | ENSP00000377665 | ENSP00000304565 | GTPase activating protein and VPS9 domains 1 | RAB31, member RAS oncogene family; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Required for the integrity and for normal function of the Golgi apparatus and the trans-Golgi network. Plays a role in insulin-stimulated translocation of GLUT4 to the cell membr [...] | 0.652 |