TBC1D23 protein (Homo sapiens) - STRING network view

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Size

small nodes:
protein of unknown 3D structure

large nodes:
some 3D structure is known or predicted

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

TBC1D23

TBC1 domain family, member 23 (699 aa)

Predicted Functional Partners:

TBC1D25

0.713

STK11

0.688

UBC

0.626

RAB3GAP2

0.591

TBC1D2B

0.576

TBC1D15

0.574

VPS26B

0.549

TBC1D17

0.548

TBC1D7

0.544

VPS26A

0.530

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but resolution at 400 dpi

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as simple tabular text output:

download

TSV: tab separated values - can be opened in Excel

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and annotated functions of the network proteins

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
RAB3GAP2	TBC1D15	ENSP00000351832	ENSP00000448182	RAB3 GTPase activating protein subunit 2 (non-catalytic); Regulatory subunit of a GTPase activating protein that has specificity for Rab3 subfamily (RAB3A, RAB3B, RAB3C and RAB3D). Rab3 proteins are involved in regulated exocytosis of neurotransmitters and hormones. Rab3 GTPase-activating complex specifically converts active Rab3-GTP to the inactive form Rab3- GDP. Required for normal eye and brain development. May participate in neurodevelopmental processes such as proliferation, migration and differentiation before synapse formation, and non- synaptic vesicular release of neurotransmitters	TBC1 domain family, member 15; Acts as a GTPase activating protein for RAB7A. Does not act on RAB4, RAB5 or RAB6 (By similarity)	0.569
RAB3GAP2	TBC1D17	ENSP00000351832	ENSP00000221543	RAB3 GTPase activating protein subunit 2 (non-catalytic); Regulatory subunit of a GTPase activating protein that has specificity for Rab3 subfamily (RAB3A, RAB3B, RAB3C and RAB3D). Rab3 proteins are involved in regulated exocytosis of neurotransmitters and hormones. Rab3 GTPase-activating complex specifically converts active Rab3-GTP to the inactive form Rab3- GDP. Required for normal eye and brain development. May participate in neurodevelopmental processes such as proliferation, migration and differentiation before synapse formation, and non- synaptic vesicular release of neurotransmitters	TBC1 domain family, member 17; May act as a GTPase-activating protein for Rab family protein(s)	0.439
RAB3GAP2	TBC1D23	ENSP00000351832	ENSP00000377700	RAB3 GTPase activating protein subunit 2 (non-catalytic); Regulatory subunit of a GTPase activating protein that has specificity for Rab3 subfamily (RAB3A, RAB3B, RAB3C and RAB3D). Rab3 proteins are involved in regulated exocytosis of neurotransmitters and hormones. Rab3 GTPase-activating complex specifically converts active Rab3-GTP to the inactive form Rab3- GDP. Required for normal eye and brain development. May participate in neurodevelopmental processes such as proliferation, migration and differentiation before synapse formation, and non- synaptic vesicular release of neurotransmitters	TBC1 domain family, member 23	0.591
RAB3GAP2	TBC1D25	ENSP00000351832	ENSP00000365962	RAB3 GTPase activating protein subunit 2 (non-catalytic); Regulatory subunit of a GTPase activating protein that has specificity for Rab3 subfamily (RAB3A, RAB3B, RAB3C and RAB3D). Rab3 proteins are involved in regulated exocytosis of neurotransmitters and hormones. Rab3 GTPase-activating complex specifically converts active Rab3-GTP to the inactive form Rab3- GDP. Required for normal eye and brain development. May participate in neurodevelopmental processes such as proliferation, migration and differentiation before synapse formation, and non- synaptic vesicular release of neurotransmitters	TBC1 domain family, member 25; Acts as a GTPase-activating protein specific for RAB33B. Involved in the regulation of autophagosome maturation, the process in which autophagosomes fuse with endosomes and lysosomes	0.640
RAB3GAP2	UBC	ENSP00000351832	ENSP00000344818	RAB3 GTPase activating protein subunit 2 (non-catalytic); Regulatory subunit of a GTPase activating protein that has specificity for Rab3 subfamily (RAB3A, RAB3B, RAB3C and RAB3D). Rab3 proteins are involved in regulated exocytosis of neurotransmitters and hormones. Rab3 GTPase-activating complex specifically converts active Rab3-GTP to the inactive form Rab3- GDP. Required for normal eye and brain development. May participate in neurodevelopmental processes such as proliferation, migration and differentiation before synapse formation, and non- synaptic vesicular release of neurotransmitters	ubiquitin C	0.943
STK11	TBC1D23	ENSP00000324856	ENSP00000377700	serine/threonine kinase 11; Tumor suppressor serine/threonine-protein kinase that controls the activity of AMP-activated protein kinase (AMPK) family members, thereby playing a role in various processes such as cell metabolism, cell polarity, apoptosis and DNA damage response. Acts by phosphorylating the T-loop of AMPK family proteins, leading to promote their activity- phosphorylates PRKAA1, PRKAA2, BRSK1, BRSK2, MARK1, MARK2, MARK3, MARK4, NUAK1, NUAK2, SIK1, SIK2, SIK3 and SNRK but not MELK. Also phosphorylates non-AMPK family proteins such as STRADA and possibly p53/TP53. Acts as a [...]	TBC1 domain family, member 23	0.688
STK11	UBC	ENSP00000324856	ENSP00000344818	serine/threonine kinase 11; Tumor suppressor serine/threonine-protein kinase that controls the activity of AMP-activated protein kinase (AMPK) family members, thereby playing a role in various processes such as cell metabolism, cell polarity, apoptosis and DNA damage response. Acts by phosphorylating the T-loop of AMPK family proteins, leading to promote their activity- phosphorylates PRKAA1, PRKAA2, BRSK1, BRSK2, MARK1, MARK2, MARK3, MARK4, NUAK1, NUAK2, SIK1, SIK2, SIK3 and SNRK but not MELK. Also phosphorylates non-AMPK family proteins such as STRADA and possibly p53/TP53. Acts as a [...]	ubiquitin C	0.626
TBC1D15	RAB3GAP2	ENSP00000448182	ENSP00000351832	TBC1 domain family, member 15; Acts as a GTPase activating protein for RAB7A. Does not act on RAB4, RAB5 or RAB6 (By similarity)	RAB3 GTPase activating protein subunit 2 (non-catalytic); Regulatory subunit of a GTPase activating protein that has specificity for Rab3 subfamily (RAB3A, RAB3B, RAB3C and RAB3D). Rab3 proteins are involved in regulated exocytosis of neurotransmitters and hormones. Rab3 GTPase-activating complex specifically converts active Rab3-GTP to the inactive form Rab3- GDP. Required for normal eye and brain development. May participate in neurodevelopmental processes such as proliferation, migration and differentiation before synapse formation, and non- synaptic vesicular release of neurotransmitters	0.569
TBC1D15	TBC1D23	ENSP00000448182	ENSP00000377700	TBC1 domain family, member 15; Acts as a GTPase activating protein for RAB7A. Does not act on RAB4, RAB5 or RAB6 (By similarity)	TBC1 domain family, member 23	0.574
TBC1D15	TBC1D7	ENSP00000448182	ENSP00000348813	TBC1 domain family, member 15; Acts as a GTPase activating protein for RAB7A. Does not act on RAB4, RAB5 or RAB6 (By similarity)	TBC1 domain family, member 7; Component of the TSC-TBC complex, that contains TBC1D7 in addition to the TSC1-TSC2 complex and consists of the functional complex possessing GTPase-activating protein (GAP) activity toward RHEB in response to alterations in specific cellular growth conditions. The small GTPase RHEB is a direct activator of the protein kinase activity of mTORC1 and the TSC-TBC complex acts as a negative regulator of mTORC1 signaling cascade by acting as a GAP for RHEB. Participates in the proper sensing of growth factors and glucose, but not amino acids, by mTORC1. It is u [...]	0.404
TBC1D15	UBC	ENSP00000448182	ENSP00000344818	TBC1 domain family, member 15; Acts as a GTPase activating protein for RAB7A. Does not act on RAB4, RAB5 or RAB6 (By similarity)	ubiquitin C	0.982
TBC1D15	VPS26A	ENSP00000448182	ENSP00000263559	TBC1 domain family, member 15; Acts as a GTPase activating protein for RAB7A. Does not act on RAB4, RAB5 or RAB6 (By similarity)	vacuolar protein sorting 26 homolog A (S. pombe); Essential component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi network. Also required to regulate transcytosis of the polymeric immunoglobulin receptor (pIgR-pIgA)	0.661
TBC1D17	RAB3GAP2	ENSP00000221543	ENSP00000351832	TBC1 domain family, member 17; May act as a GTPase-activating protein for Rab family protein(s)	RAB3 GTPase activating protein subunit 2 (non-catalytic); Regulatory subunit of a GTPase activating protein that has specificity for Rab3 subfamily (RAB3A, RAB3B, RAB3C and RAB3D). Rab3 proteins are involved in regulated exocytosis of neurotransmitters and hormones. Rab3 GTPase-activating complex specifically converts active Rab3-GTP to the inactive form Rab3- GDP. Required for normal eye and brain development. May participate in neurodevelopmental processes such as proliferation, migration and differentiation before synapse formation, and non- synaptic vesicular release of neurotransmitters	0.439
TBC1D17	TBC1D23	ENSP00000221543	ENSP00000377700	TBC1 domain family, member 17; May act as a GTPase-activating protein for Rab family protein(s)	TBC1 domain family, member 23	0.548
TBC1D17	UBC	ENSP00000221543	ENSP00000344818	TBC1 domain family, member 17; May act as a GTPase-activating protein for Rab family protein(s)	ubiquitin C	0.774
TBC1D17	VPS26A	ENSP00000221543	ENSP00000263559	TBC1 domain family, member 17; May act as a GTPase-activating protein for Rab family protein(s)	vacuolar protein sorting 26 homolog A (S. pombe); Essential component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi network. Also required to regulate transcytosis of the polymeric immunoglobulin receptor (pIgR-pIgA)	0.414
TBC1D23	RAB3GAP2	ENSP00000377700	ENSP00000351832	TBC1 domain family, member 23	RAB3 GTPase activating protein subunit 2 (non-catalytic); Regulatory subunit of a GTPase activating protein that has specificity for Rab3 subfamily (RAB3A, RAB3B, RAB3C and RAB3D). Rab3 proteins are involved in regulated exocytosis of neurotransmitters and hormones. Rab3 GTPase-activating complex specifically converts active Rab3-GTP to the inactive form Rab3- GDP. Required for normal eye and brain development. May participate in neurodevelopmental processes such as proliferation, migration and differentiation before synapse formation, and non- synaptic vesicular release of neurotransmitters	0.591
TBC1D23	STK11	ENSP00000377700	ENSP00000324856	TBC1 domain family, member 23	serine/threonine kinase 11; Tumor suppressor serine/threonine-protein kinase that controls the activity of AMP-activated protein kinase (AMPK) family members, thereby playing a role in various processes such as cell metabolism, cell polarity, apoptosis and DNA damage response. Acts by phosphorylating the T-loop of AMPK family proteins, leading to promote their activity- phosphorylates PRKAA1, PRKAA2, BRSK1, BRSK2, MARK1, MARK2, MARK3, MARK4, NUAK1, NUAK2, SIK1, SIK2, SIK3 and SNRK but not MELK. Also phosphorylates non-AMPK family proteins such as STRADA and possibly p53/TP53. Acts as a [...]	0.688
TBC1D23	TBC1D15	ENSP00000377700	ENSP00000448182	TBC1 domain family, member 23	TBC1 domain family, member 15; Acts as a GTPase activating protein for RAB7A. Does not act on RAB4, RAB5 or RAB6 (By similarity)	0.574
TBC1D23	TBC1D17	ENSP00000377700	ENSP00000221543	TBC1 domain family, member 23	TBC1 domain family, member 17; May act as a GTPase-activating protein for Rab family protein(s)	0.548

page 1 of 4

Experiments

Cooccurrence

Textmining

Neighborhood

Coexpression

Fusion

Databases

© STRING Consortium 2017

Credits

Access

Info

About