MIEN1 protein (Homo sapiens) - STRING network view

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Size

small nodes:
protein of unknown 3D structure

large nodes:
some 3D structure is known or predicted

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

MIEN1

migration and invasion enhancer 1; Increases cell migration by inducing filopodia formation at the leading edge of migrating cells. Plays a role in regulation of apoptosis, possibly through control of CASP3. May be involved in a redox-related process (115 aa)

Predicted Functional Partners:

GPX1

0.928

SELT

0.873

SEPW1

0.818

PRDX1

0.744

PGAP3

0.721

VIMP

0.681

C11orf31

0.628

C2orf29

0.623

GRB7

0.581

STARD3

0.561

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but resolution at 400 dpi

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as simple tabular text output:

download

TSV: tab separated values - can be opened in Excel

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and annotated functions of the network proteins

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
C11orf31	GPX1	ENSP00000373509	ENSP00000407375	chromosome 11 open reading frame 31; May be involved in a redox-related process (Potential)	glutathione peroxidase 1; Protects the hemoglobin in erythrocytes from oxidative breakdown	0.630
C11orf31	MIEN1	ENSP00000373509	ENSP00000377778	chromosome 11 open reading frame 31; May be involved in a redox-related process (Potential)	migration and invasion enhancer 1; Increases cell migration by inducing filopodia formation at the leading edge of migrating cells. Plays a role in regulation of apoptosis, possibly through control of CASP3. May be involved in a redox-related process	0.628
C11orf31	SELT	ENSP00000373509	ENSP00000418910	chromosome 11 open reading frame 31; May be involved in a redox-related process (Potential)	selenoprotein T precursor	0.753
C11orf31	SEPW1	ENSP00000373509	ENSP00000422644	chromosome 11 open reading frame 31; May be involved in a redox-related process (Potential)	selenoprotein W, 1; Plays a role as a glutathione (GSH)-dependent antioxidant. May be involved in a redox-related process. May play a role in the myopathies of selenium deficiency (By similarity)	0.772
C11orf31	VIMP	ENSP00000373509	ENSP00000381282	chromosome 11 open reading frame 31; May be involved in a redox-related process (Potential)	VCP-interacting membrane protein; Involved in the degradation process of misfolded endoplasmic reticulum (ER) luminal proteins. Participates in the transfer of misfolded proteins from the ER to the cytosol, where they are destroyed by the proteasome in a ubiquitin-dependent manner. Probably acts by serving as a linker between DERL1, which mediates the retrotranslocation of misfolded proteins into the cytosol, and the ATPase complex VCP, which mediates the translocation and ubiquitination	0.812
C2orf29	MIEN1	ENSP00000289382	ENSP00000377778	chromosome 2 open reading frame 29; Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Is required for the association of CNOT10 with the CCR4-NOT complex. Seems not to be required for complex deadenylase function	migration and invasion enhancer 1; Increases cell migration by inducing filopodia formation at the leading edge of migrating cells. Plays a role in regulation of apoptosis, possibly through control of CASP3. May be involved in a redox-related process	0.623
GPX1	C11orf31	ENSP00000407375	ENSP00000373509	glutathione peroxidase 1; Protects the hemoglobin in erythrocytes from oxidative breakdown	chromosome 11 open reading frame 31; May be involved in a redox-related process (Potential)	0.630
GPX1	MIEN1	ENSP00000407375	ENSP00000377778	glutathione peroxidase 1; Protects the hemoglobin in erythrocytes from oxidative breakdown	migration and invasion enhancer 1; Increases cell migration by inducing filopodia formation at the leading edge of migrating cells. Plays a role in regulation of apoptosis, possibly through control of CASP3. May be involved in a redox-related process	0.928
GPX1	PRDX1	ENSP00000407375	ENSP00000262746	glutathione peroxidase 1; Protects the hemoglobin in erythrocytes from oxidative breakdown	peroxiredoxin 1; Involved in redox regulation of the cell. Reduces peroxides with reducing equivalents provided through the thioredoxin system but not from glutaredoxin. May play an important role in eliminating peroxides generated during metabolism. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2). Reduces an intramolecular disulfide bond in GDPD5 that gates the ability to GDPD5 to drive postmitotic motor neuron differentiation (By similarity)	0.857
GPX1	SELT	ENSP00000407375	ENSP00000418910	glutathione peroxidase 1; Protects the hemoglobin in erythrocytes from oxidative breakdown	selenoprotein T precursor	0.587
GPX1	SEPW1	ENSP00000407375	ENSP00000422644	glutathione peroxidase 1; Protects the hemoglobin in erythrocytes from oxidative breakdown	selenoprotein W, 1; Plays a role as a glutathione (GSH)-dependent antioxidant. May be involved in a redox-related process. May play a role in the myopathies of selenium deficiency (By similarity)	0.647
GPX1	VIMP	ENSP00000407375	ENSP00000381282	glutathione peroxidase 1; Protects the hemoglobin in erythrocytes from oxidative breakdown	VCP-interacting membrane protein; Involved in the degradation process of misfolded endoplasmic reticulum (ER) luminal proteins. Participates in the transfer of misfolded proteins from the ER to the cytosol, where they are destroyed by the proteasome in a ubiquitin-dependent manner. Probably acts by serving as a linker between DERL1, which mediates the retrotranslocation of misfolded proteins into the cytosol, and the ATPase complex VCP, which mediates the translocation and ubiquitination	0.818
GRB7	MIEN1	ENSP00000403459	ENSP00000377778	growth factor receptor-bound protein 7	migration and invasion enhancer 1; Increases cell migration by inducing filopodia formation at the leading edge of migrating cells. Plays a role in regulation of apoptosis, possibly through control of CASP3. May be involved in a redox-related process	0.581
GRB7	PGAP3	ENSP00000403459	ENSP00000300658	growth factor receptor-bound protein 7	post-GPI attachment to proteins 3; Involved in the lipid remodeling steps of GPI-anchor maturation. Lipid remodeling steps consist in the generation of 2 saturated fatty chains at the sn-2 position of GPI-anchors proteins. Required for phospholipase A2 activity that removes an acyl-chain at the sn-2 position of GPI-anchors during the remodeling of GPI (Probable)	0.700
GRB7	STARD3	ENSP00000403459	ENSP00000337446	growth factor receptor-bound protein 7	StAR-related lipid transfer (START) domain containing 3; Binds and transports cholesterol. Promotes steroidogenesis in placenta and brain	0.720
MIEN1	C11orf31	ENSP00000377778	ENSP00000373509	migration and invasion enhancer 1; Increases cell migration by inducing filopodia formation at the leading edge of migrating cells. Plays a role in regulation of apoptosis, possibly through control of CASP3. May be involved in a redox-related process	chromosome 11 open reading frame 31; May be involved in a redox-related process (Potential)	0.628
MIEN1	C2orf29	ENSP00000377778	ENSP00000289382	migration and invasion enhancer 1; Increases cell migration by inducing filopodia formation at the leading edge of migrating cells. Plays a role in regulation of apoptosis, possibly through control of CASP3. May be involved in a redox-related process	chromosome 2 open reading frame 29; Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Is required for the association of CNOT10 with the CCR4-NOT complex. Seems not to be required for complex deadenylase function	0.623
MIEN1	GPX1	ENSP00000377778	ENSP00000407375	migration and invasion enhancer 1; Increases cell migration by inducing filopodia formation at the leading edge of migrating cells. Plays a role in regulation of apoptosis, possibly through control of CASP3. May be involved in a redox-related process	glutathione peroxidase 1; Protects the hemoglobin in erythrocytes from oxidative breakdown	0.928
MIEN1	GRB7	ENSP00000377778	ENSP00000403459	migration and invasion enhancer 1; Increases cell migration by inducing filopodia formation at the leading edge of migrating cells. Plays a role in regulation of apoptosis, possibly through control of CASP3. May be involved in a redox-related process	growth factor receptor-bound protein 7	0.581
MIEN1	PGAP3	ENSP00000377778	ENSP00000300658	migration and invasion enhancer 1; Increases cell migration by inducing filopodia formation at the leading edge of migrating cells. Plays a role in regulation of apoptosis, possibly through control of CASP3. May be involved in a redox-related process	post-GPI attachment to proteins 3; Involved in the lipid remodeling steps of GPI-anchor maturation. Lipid remodeling steps consist in the generation of 2 saturated fatty chains at the sn-2 position of GPI-anchors proteins. Required for phospholipase A2 activity that removes an acyl-chain at the sn-2 position of GPI-anchors during the remodeling of GPI (Probable)	0.721

page 1 of 3

Experiments

Cooccurrence

Textmining

Neighborhood

Databases

Fusion

Coexpression

© STRING Consortium 2017

Credits

Access

Info

About