node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
KDM8 | RCCD1 | ENSP00000398410 | ENSP00000377801 | lysine (K)-specific demethylase 8; Histone demethylase required for G2/M phase cell cycle progression. Specifically demethylates dimethylated ’Lys-36’ (H3K36me2) of histone H3, an epigenetic repressive mark, thereby acting as a transcription activator. Regulates expression of CCNA1 (cyclin-A1), leading to regulate cancer cell proliferation | RCC1 domain containing 1 | 0.604 |
NUBP1 | RCCD1 | ENSP00000283027 | ENSP00000377801 | nucleotide binding protein 1; Implicated in the regulation of centrosome duplication (By similarity). Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins | RCC1 domain containing 1 | 0.644 |
NUBP1 | UBC | ENSP00000283027 | ENSP00000344818 | nucleotide binding protein 1; Implicated in the regulation of centrosome duplication (By similarity). Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins | ubiquitin C | 0.620 |
RAN | RANBP2 | ENSP00000376176 | ENSP00000283195 | RAN, member RAS oncogene family | RAN binding protein 2; E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I. Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates. Could also have isomerase or chaperone activity and may bind RNA or DNA. Component of the nuclear export pathway. Specific docking site for the nuclear export factor exportin-1. Sumoylates PML at ’Lys-490’ which is essential for the proper assembly of PML-NB | 0.999 |
RAN | RANGRF | ENSP00000376176 | ENSP00000226105 | RAN, member RAS oncogene family | RAN guanine nucleotide release factor; May regulate the intracellular trafficking of RAN. In cardiac cells seems to regulate the cell surface localization of SCN5A | 0.995 |
RAN | RCCD1 | ENSP00000376176 | ENSP00000377801 | RAN, member RAS oncogene family | RCC1 domain containing 1 | 0.662 |
RAN | RGPD1 | ENSP00000376176 | ENSP00000381253 | RAN, member RAS oncogene family | RANBP2-like and GRIP domain containing 1 | 0.904 |
RAN | RGPD3 | ENSP00000376176 | ENSP00000386588 | RAN, member RAS oncogene family | RANBP2-like and GRIP domain containing 3 | 0.904 |
RAN | RGPD4 | ENSP00000376176 | ENSP00000386810 | RAN, member RAS oncogene family | RANBP2-like and GRIP domain containing 4 | 0.919 |
RAN | UBC | ENSP00000376176 | ENSP00000344818 | RAN, member RAS oncogene family | ubiquitin C | 0.996 |
RANBP2 | RAN | ENSP00000283195 | ENSP00000376176 | RAN binding protein 2; E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I. Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates. Could also have isomerase or chaperone activity and may bind RNA or DNA. Component of the nuclear export pathway. Specific docking site for the nuclear export factor exportin-1. Sumoylates PML at ’Lys-490’ which is essential for the proper assembly of PML-NB | RAN, member RAS oncogene family | 0.999 |
RANBP2 | RCCD1 | ENSP00000283195 | ENSP00000377801 | RAN binding protein 2; E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I. Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates. Could also have isomerase or chaperone activity and may bind RNA or DNA. Component of the nuclear export pathway. Specific docking site for the nuclear export factor exportin-1. Sumoylates PML at ’Lys-490’ which is essential for the proper assembly of PML-NB | RCC1 domain containing 1 | 0.584 |
RANBP2 | UBC | ENSP00000283195 | ENSP00000344818 | RAN binding protein 2; E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I. Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates. Could also have isomerase or chaperone activity and may bind RNA or DNA. Component of the nuclear export pathway. Specific docking site for the nuclear export factor exportin-1. Sumoylates PML at ’Lys-490’ which is essential for the proper assembly of PML-NB | ubiquitin C | 0.992 |
RANGRF | RAN | ENSP00000226105 | ENSP00000376176 | RAN guanine nucleotide release factor; May regulate the intracellular trafficking of RAN. In cardiac cells seems to regulate the cell surface localization of SCN5A | RAN, member RAS oncogene family | 0.995 |
RANGRF | RCCD1 | ENSP00000226105 | ENSP00000377801 | RAN guanine nucleotide release factor; May regulate the intracellular trafficking of RAN. In cardiac cells seems to regulate the cell surface localization of SCN5A | RCC1 domain containing 1 | 0.680 |
RANGRF | UBC | ENSP00000226105 | ENSP00000344818 | RAN guanine nucleotide release factor; May regulate the intracellular trafficking of RAN. In cardiac cells seems to regulate the cell surface localization of SCN5A | ubiquitin C | 0.509 |
RCCD1 | KDM8 | ENSP00000377801 | ENSP00000398410 | RCC1 domain containing 1 | lysine (K)-specific demethylase 8; Histone demethylase required for G2/M phase cell cycle progression. Specifically demethylates dimethylated ’Lys-36’ (H3K36me2) of histone H3, an epigenetic repressive mark, thereby acting as a transcription activator. Regulates expression of CCNA1 (cyclin-A1), leading to regulate cancer cell proliferation | 0.604 |
RCCD1 | NUBP1 | ENSP00000377801 | ENSP00000283027 | RCC1 domain containing 1 | nucleotide binding protein 1; Implicated in the regulation of centrosome duplication (By similarity). Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins | 0.644 |
RCCD1 | RAN | ENSP00000377801 | ENSP00000376176 | RCC1 domain containing 1 | RAN, member RAS oncogene family | 0.662 |
RCCD1 | RANBP2 | ENSP00000377801 | ENSP00000283195 | RCC1 domain containing 1 | RAN binding protein 2; E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I. Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates. Could also have isomerase or chaperone activity and may bind RNA or DNA. Component of the nuclear export pathway. Specific docking site for the nuclear export factor exportin-1. Sumoylates PML at ’Lys-490’ which is essential for the proper assembly of PML-NB | 0.584 |