Full Link:
  • Version:
  • 10.0 (archived version)
STRINGSTRING
NUBP1 NUBP1 UBC UBC RGPD3 RGPD3 KDM8 KDM8 RANBP2 RANBP2 RGPD4 RGPD4 RCCD1 RCCD1 RAN RAN RANGRF RANGRF RGPD1 RGPD1 WDFY4 WDFY4
"RCCD1" - RCC1 domain containing 1 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
RCCD1RCC1 domain containing 1 (376 aa)    
Predicted Functional Partners:
UBC
ubiquitin C (685 aa)
        score_image       0.893
WDFY4
WDFY family member 4 (3184 aa)
            score_image   0.716
RANGRF
RAN guanine nucleotide release factor; May regulate the intracellular trafficking of RAN. In cardiac cells seems to regulate the cell surface localization of SCN5A (186 aa)
        score_image   score_image   0.680
RAN
RAN, member RAS oncogene family (216 aa)
      score_image score_image   score_image   0.662
NUBP1
nucleotide binding protein 1; Implicated in the regulation of centrosome duplication (By similarity). Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins (320 aa)
        score_image       0.644
KDM8
lysine (K)-specific demethylase 8; Histone demethylase required for G2/M phase cell cycle progression. Specifically demethylates dimethylated ’Lys-36’ (H3K36me2) of histone H3, an epigenetic repressive mark, thereby acting as a transcription activator. Regulates expression of CCNA1 (cyclin-A1), leading to regulate cancer cell proliferation (454 aa)
        score_image   score_image   0.604
RANBP2
RAN binding protein 2; E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I. Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates. Could also have isomerase or chaperone activity and may bind RNA or DNA. Component of the nuclear export pathway. Specific docking site for the nuclear export factor exportin-1. Sumoylates PML at ’Lys-490’ which is essential for the proper assembly of PML-NB (3224 aa)
      score_image score_image   score_image   0.584
RGPD4
RANBP2-like and GRIP domain containing 4 (1758 aa)
      score_image score_image   score_image   0.577
RGPD3
RANBP2-like and GRIP domain containing 3 (1758 aa)
      score_image score_image   score_image   0.577
RGPD1
RANBP2-like and GRIP domain containing 1 (1756 aa)
      score_image score_image   score_image   0.577
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Server load: low (34%)