node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
DLX1 | FGF8 | ENSP00000354478 | ENSP00000321797 | distal-less homeobox 1; Likely to play a regulatory role in the development of the ventral forebrain. May play a role in craniofacial patterning and morphogenesis and may be involved in the early development of diencephalic subdivisions (By similarity) | fibroblast growth factor 8 (androgen-induced); Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. Required for normal brain, eye, ear and limb development during embryogenesis. Required for normal development of the gonadotropin-releasing hormone (GnRH) neuronal system | 0.892 |
DLX1 | LHX6 | ENSP00000354478 | ENSP00000377854 | distal-less homeobox 1; Likely to play a regulatory role in the development of the ventral forebrain. May play a role in craniofacial patterning and morphogenesis and may be involved in the early development of diencephalic subdivisions (By similarity) | LIM homeobox 6 | 0.759 |
DLX2 | FGF8 | ENSP00000234198 | ENSP00000321797 | distal-less homeobox 2; Likely to play a regulatory role in the development of the ventral forebrain. May play a role in craniofacial patterning and morphogenesis | fibroblast growth factor 8 (androgen-induced); Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. Required for normal brain, eye, ear and limb development during embryogenesis. Required for normal development of the gonadotropin-releasing hormone (GnRH) neuronal system | 0.975 |
DLX2 | LHX6 | ENSP00000234198 | ENSP00000377854 | distal-less homeobox 2; Likely to play a regulatory role in the development of the ventral forebrain. May play a role in craniofacial patterning and morphogenesis | LIM homeobox 6 | 0.750 |
FGF8 | DLX1 | ENSP00000321797 | ENSP00000354478 | fibroblast growth factor 8 (androgen-induced); Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. Required for normal brain, eye, ear and limb development during embryogenesis. Required for normal development of the gonadotropin-releasing hormone (GnRH) neuronal system | distal-less homeobox 1; Likely to play a regulatory role in the development of the ventral forebrain. May play a role in craniofacial patterning and morphogenesis and may be involved in the early development of diencephalic subdivisions (By similarity) | 0.892 |
FGF8 | DLX2 | ENSP00000321797 | ENSP00000234198 | fibroblast growth factor 8 (androgen-induced); Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. Required for normal brain, eye, ear and limb development during embryogenesis. Required for normal development of the gonadotropin-releasing hormone (GnRH) neuronal system | distal-less homeobox 2; Likely to play a regulatory role in the development of the ventral forebrain. May play a role in craniofacial patterning and morphogenesis | 0.975 |
FGF8 | LHX6 | ENSP00000321797 | ENSP00000377854 | fibroblast growth factor 8 (androgen-induced); Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. Required for normal brain, eye, ear and limb development during embryogenesis. Required for normal development of the gonadotropin-releasing hormone (GnRH) neuronal system | LIM homeobox 6 | 0.883 |
FGF8 | NKX2-1 | ENSP00000321797 | ENSP00000346879 | fibroblast growth factor 8 (androgen-induced); Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. Required for normal brain, eye, ear and limb development during embryogenesis. Required for normal development of the gonadotropin-releasing hormone (GnRH) neuronal system | NK2 homeobox 1; Transcription factor that binds and activates the promoter of thyroid specific genes such as thyroglobulin, thyroperoxidase, and thyrotropin receptor. Crucial in the maintenance of the thyroid differentiation phenotype. May play a role in lung development and surfactant homeostasis | 0.954 |
LDB1 | LHX6 | ENSP00000392466 | ENSP00000377854 | LIM domain binding 1; Binds to the LIM domain of a wide variety of LIM domain- containing transcription factors. May regulate the transcriptional activity of LIM-containing proteins by determining specific partner interactions. Play a role in the development of interneurons and motor neurons in cooperation with LHX3 and ISL1. Acts synergistically with LHX1/LIM1 in axis formation and activation of gene expression. Acts with LMO2 in the regulation of red blood cell development, maintaining erythroid precursors in an immature state (By similarity) | LIM homeobox 6 | 0.974 |
LDB1 | PDE1C | ENSP00000392466 | ENSP00000379496 | LIM domain binding 1; Binds to the LIM domain of a wide variety of LIM domain- containing transcription factors. May regulate the transcriptional activity of LIM-containing proteins by determining specific partner interactions. Play a role in the development of interneurons and motor neurons in cooperation with LHX3 and ISL1. Acts synergistically with LHX1/LIM1 in axis formation and activation of gene expression. Acts with LMO2 in the regulation of red blood cell development, maintaining erythroid precursors in an immature state (By similarity) | phosphodiesterase 1C, calmodulin-dependent 70kDa; Cyclic nucleotide phosphodiesterase with a dual- specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a high affinity for both cAMP and cGMP | 0.515 |
LDB2 | LHX6 | ENSP00000306772 | ENSP00000377854 | LIM domain binding 2; Binds to the LIM domain of a wide variety of LIM domain- containing transcription factors | LIM homeobox 6 | 0.944 |
LDB2 | PDE1C | ENSP00000306772 | ENSP00000379496 | LIM domain binding 2; Binds to the LIM domain of a wide variety of LIM domain- containing transcription factors | phosphodiesterase 1C, calmodulin-dependent 70kDa; Cyclic nucleotide phosphodiesterase with a dual- specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a high affinity for both cAMP and cGMP | 0.561 |
LHX6 | DLX1 | ENSP00000377854 | ENSP00000354478 | LIM homeobox 6 | distal-less homeobox 1; Likely to play a regulatory role in the development of the ventral forebrain. May play a role in craniofacial patterning and morphogenesis and may be involved in the early development of diencephalic subdivisions (By similarity) | 0.759 |
LHX6 | DLX2 | ENSP00000377854 | ENSP00000234198 | LIM homeobox 6 | distal-less homeobox 2; Likely to play a regulatory role in the development of the ventral forebrain. May play a role in craniofacial patterning and morphogenesis | 0.750 |
LHX6 | FGF8 | ENSP00000377854 | ENSP00000321797 | LIM homeobox 6 | fibroblast growth factor 8 (androgen-induced); Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. Required for normal brain, eye, ear and limb development during embryogenesis. Required for normal development of the gonadotropin-releasing hormone (GnRH) neuronal system | 0.883 |
LHX6 | LDB1 | ENSP00000377854 | ENSP00000392466 | LIM homeobox 6 | LIM domain binding 1; Binds to the LIM domain of a wide variety of LIM domain- containing transcription factors. May regulate the transcriptional activity of LIM-containing proteins by determining specific partner interactions. Play a role in the development of interneurons and motor neurons in cooperation with LHX3 and ISL1. Acts synergistically with LHX1/LIM1 in axis formation and activation of gene expression. Acts with LMO2 in the regulation of red blood cell development, maintaining erythroid precursors in an immature state (By similarity) | 0.974 |
LHX6 | LDB2 | ENSP00000377854 | ENSP00000306772 | LIM homeobox 6 | LIM domain binding 2; Binds to the LIM domain of a wide variety of LIM domain- containing transcription factors | 0.944 |
LHX6 | NKX2-1 | ENSP00000377854 | ENSP00000346879 | LIM homeobox 6 | NK2 homeobox 1; Transcription factor that binds and activates the promoter of thyroid specific genes such as thyroglobulin, thyroperoxidase, and thyrotropin receptor. Crucial in the maintenance of the thyroid differentiation phenotype. May play a role in lung development and surfactant homeostasis | 0.779 |
LHX6 | PDE1A | ENSP00000377854 | ENSP00000331574 | LIM homeobox 6 | phosphodiesterase 1A, calmodulin-dependent | 0.748 |
LHX6 | PDE1C | ENSP00000377854 | ENSP00000379496 | LIM homeobox 6 | phosphodiesterase 1C, calmodulin-dependent 70kDa; Cyclic nucleotide phosphodiesterase with a dual- specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a high affinity for both cAMP and cGMP | 0.869 |