| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| HNF4G | MED1 | ENSP00000379701 | ENSP00000300651 | hepatocyte nuclear factor 4, gamma; Transcription factor. Has a lower transcription activation potential than HNF4-alpha | mediator complex subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors | 0.915 |
| HNF4G | NR0B2 | ENSP00000379701 | ENSP00000254227 | hepatocyte nuclear factor 4, gamma; Transcription factor. Has a lower transcription activation potential than HNF4-alpha | nuclear receptor subfamily 0, group B, member 2; Acts as a transcriptional regulator. Acts as a negative regulator of receptor-dependent signaling pathways. Specifically inhibits transactivation of the nuclear receptor with whom it interacts. Inhibits transcriptional activity of NEUROD1 on E-box- containing promoter by interfering with the coactivation function of the p300/CBP-mediated trancription complex for NEUROD1 | 0.929 |
| HNF4G | NR2F6 | ENSP00000379701 | ENSP00000291442 | hepatocyte nuclear factor 4, gamma; Transcription factor. Has a lower transcription activation potential than HNF4-alpha | nuclear receptor subfamily 2, group F, member 6; Transcription factor predominantly involved in transcriptional repression. Binds to promoter/enhancer response elements that contain the imperfect 5’-AGGTCA-3’ direct or inverted repeats with various spacings which are also recognized by other nuclear hormone receptors. Involved in modulation of hormonal responses. Represses transcriptional activity of the lutropin-choriogonadotropic hormone receptor/LHCGR gene, the renin/REN gene and the oxytocin-neurophysin/OXT gene. Represses the triiodothyronine-dependent and -independent transcripti [...] | 0.911 |
| HNF4G | NR4A1 | ENSP00000379701 | ENSP00000353427 | hepatocyte nuclear factor 4, gamma; Transcription factor. Has a lower transcription activation potential than HNF4-alpha | nuclear receptor subfamily 4, group A, member 1; Orphan nuclear receptor. May act concomitantly with NURR1 in regulating the expression of delayed-early genes during liver regeneration. Binds the NGFI-B response element (NBRE) 5’- AAAAGGTCA-3’ (By similarity). May inhibit NF-kappa-B transactivation of IL2 | 0.905 |
| HNF4G | NR4A2 | ENSP00000379701 | ENSP00000344479 | hepatocyte nuclear factor 4, gamma; Transcription factor. Has a lower transcription activation potential than HNF4-alpha | nuclear receptor subfamily 4, group A, member 2; Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development. It is crucial for expression of a set of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons (By similarity) | 0.906 |
| HNF4G | NRBP1 | ENSP00000379701 | ENSP00000233557 | hepatocyte nuclear factor 4, gamma; Transcription factor. Has a lower transcription activation potential than HNF4-alpha | nuclear receptor binding protein 1; May play a role in subcellular trafficking between the endoplasmic reticulum and Golgi apparatus through interactions with the Rho-type GTPases. Binding to the NS3 protein of dengue virus type 2 appears to subvert this activity into the alteration of the intracellular membrane structure associated with flaviviral replication | 0.917 |
| HNF4G | RARG | ENSP00000379701 | ENSP00000377947 | hepatocyte nuclear factor 4, gamma; Transcription factor. Has a lower transcription activation potential than HNF4-alpha | retinoic acid receptor, gamma | 0.913 |
| HNF4G | RORB | ENSP00000379701 | ENSP00000366093 | hepatocyte nuclear factor 4, gamma; Transcription factor. Has a lower transcription activation potential than HNF4-alpha | RAR-related orphan receptor B; Orphan nuclear receptor required for normal postnatal development of rod and cone photoreceptor cells. Regulates transcription of OPN1SW in cone photoreceptor cells by binding the sequence 5’-AGGTCA-3’ in the OPN1SW promoter (By similarity) | 0.911 |
| HNF4G | RXRG | ENSP00000379701 | ENSP00000352900 | hepatocyte nuclear factor 4, gamma; Transcription factor. Has a lower transcription activation potential than HNF4-alpha | retinoid X receptor, gamma; Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5’-AGGTCA-3’ sites known as DR1-DR5. The high affinity ligand for RXRs is 9-cis retinoic acid (By similarity) | 0.908 |
| HNF4G | VDR | ENSP00000379701 | ENSP00000447173 | hepatocyte nuclear factor 4, gamma; Transcription factor. Has a lower transcription activation potential than HNF4-alpha | vitamin D (1,25- dihydroxyvitamin D3) receptor; Nuclear hormone receptor. Transcription factor that mediates the action of vitamin D3 by controlling the expression of hormone sensitive genes. Regulates transcription of hormone sensitive genes via its association with the WINAC complex, a chromatin-remodeling complex. Recruited to promoters via its interaction with the WINAC complex subunit BAZ1B/WSTF, which mediates the interaction with acetylated histones, an essential step for VDR-promoter association. Plays a central role in calcium homeostasis | 0.911 |
| MED1 | HNF4G | ENSP00000300651 | ENSP00000379701 | mediator complex subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors | hepatocyte nuclear factor 4, gamma; Transcription factor. Has a lower transcription activation potential than HNF4-alpha | 0.915 |
| MED1 | NR0B2 | ENSP00000300651 | ENSP00000254227 | mediator complex subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors | nuclear receptor subfamily 0, group B, member 2; Acts as a transcriptional regulator. Acts as a negative regulator of receptor-dependent signaling pathways. Specifically inhibits transactivation of the nuclear receptor with whom it interacts. Inhibits transcriptional activity of NEUROD1 on E-box- containing promoter by interfering with the coactivation function of the p300/CBP-mediated trancription complex for NEUROD1 | 0.925 |
| MED1 | NR2F6 | ENSP00000300651 | ENSP00000291442 | mediator complex subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors | nuclear receptor subfamily 2, group F, member 6; Transcription factor predominantly involved in transcriptional repression. Binds to promoter/enhancer response elements that contain the imperfect 5’-AGGTCA-3’ direct or inverted repeats with various spacings which are also recognized by other nuclear hormone receptors. Involved in modulation of hormonal responses. Represses transcriptional activity of the lutropin-choriogonadotropic hormone receptor/LHCGR gene, the renin/REN gene and the oxytocin-neurophysin/OXT gene. Represses the triiodothyronine-dependent and -independent transcripti [...] | 0.916 |
| MED1 | NR4A1 | ENSP00000300651 | ENSP00000353427 | mediator complex subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors | nuclear receptor subfamily 4, group A, member 1; Orphan nuclear receptor. May act concomitantly with NURR1 in regulating the expression of delayed-early genes during liver regeneration. Binds the NGFI-B response element (NBRE) 5’- AAAAGGTCA-3’ (By similarity). May inhibit NF-kappa-B transactivation of IL2 | 0.993 |
| MED1 | NR4A2 | ENSP00000300651 | ENSP00000344479 | mediator complex subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors | nuclear receptor subfamily 4, group A, member 2; Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development. It is crucial for expression of a set of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons (By similarity) | 0.927 |
| MED1 | NRBP1 | ENSP00000300651 | ENSP00000233557 | mediator complex subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors | nuclear receptor binding protein 1; May play a role in subcellular trafficking between the endoplasmic reticulum and Golgi apparatus through interactions with the Rho-type GTPases. Binding to the NS3 protein of dengue virus type 2 appears to subvert this activity into the alteration of the intracellular membrane structure associated with flaviviral replication | 0.904 |
| MED1 | RARG | ENSP00000300651 | ENSP00000377947 | mediator complex subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors | retinoic acid receptor, gamma | 0.925 |
| MED1 | RORB | ENSP00000300651 | ENSP00000366093 | mediator complex subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors | RAR-related orphan receptor B; Orphan nuclear receptor required for normal postnatal development of rod and cone photoreceptor cells. Regulates transcription of OPN1SW in cone photoreceptor cells by binding the sequence 5’-AGGTCA-3’ in the OPN1SW promoter (By similarity) | 0.910 |
| MED1 | RXRG | ENSP00000300651 | ENSP00000352900 | mediator complex subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors | retinoid X receptor, gamma; Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5’-AGGTCA-3’ sites known as DR1-DR5. The high affinity ligand for RXRs is 9-cis retinoic acid (By similarity) | 0.923 |
| MED1 | VDR | ENSP00000300651 | ENSP00000447173 | mediator complex subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors | vitamin D (1,25- dihydroxyvitamin D3) receptor; Nuclear hormone receptor. Transcription factor that mediates the action of vitamin D3 by controlling the expression of hormone sensitive genes. Regulates transcription of hormone sensitive genes via its association with the WINAC complex, a chromatin-remodeling complex. Recruited to promoters via its interaction with the WINAC complex subunit BAZ1B/WSTF, which mediates the interaction with acetylated histones, an essential step for VDR-promoter association. Plays a central role in calcium homeostasis | 0.999 |
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