ANKLE1 protein (Homo sapiens) - STRING network view

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ANKLE1

ankyrin repeat and LEM domain containing 1 (615 aa)

Predicted Functional Partners:

ANKLE2

0.882

LEMD2

0.818

LEMD3

0.812

TMEM43

0.592

SYNE4

0.532

NEK10

0.509

UBC

0.483

RBM23

0.463

RBM39

0.463

TMPO

0.451

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ANKLE1	ANKLE2	ENSP00000377971	ENSP00000350686	ankyrin repeat and LEM domain containing 1	ankyrin repeat and LEM domain containing 2; Involved in mitotic nuclear envelope reassembly by promoting dephosphorylation of BAF/BANF1 during mitotic exit. Coordinates the control of BAF/BANF1 dephosphorylation by inhibiting VRK1 kinase and promoting dephosphorylation of BAF/BANF1 by protein phosphatase 2A (PP2A), thereby facilitating nuclear envelope assembly. It is unclear whether it acts as a real PP2A regulatory subunit or whether it is involved in recruitment of the PP2A complex	0.882
ANKLE1	LEMD2	ENSP00000377971	ENSP00000293760	ankyrin repeat and LEM domain containing 1	LEM domain containing 2; Involved in nuclear structure organization	0.818
ANKLE1	LEMD3	ENSP00000377971	ENSP00000308369	ankyrin repeat and LEM domain containing 1	LEM domain containing 3; Can function as a specific repressor of TGF-beta, activin, and BMP signaling through its interaction with the R-SMAD proteins. Antagonizes TGF-beta-induced cell proliferation arrest	0.812
ANKLE1	NEK10	ENSP00000377971	ENSP00000343847	ankyrin repeat and LEM domain containing 1	NIMA-related kinase 10	0.509
ANKLE1	RBM23	ENSP00000377971	ENSP00000352956	ankyrin repeat and LEM domain containing 1	RNA binding motif protein 23; Probable RNA-binding protein. May be involved in pre- mRNA splicing process	0.463
ANKLE1	RBM39	ENSP00000377971	ENSP00000253363	ankyrin repeat and LEM domain containing 1	RNA binding motif protein 39; Transcriptional coactivator for steroid nuclear receptors ESR1/ER-alpha and ESR2/ER-beta, and JUN/AP-1 (By similarity). May be involved in pre-mRNA splicing process	0.463
ANKLE1	SYNE4	ENSP00000377971	ENSP00000316130	ankyrin repeat and LEM domain containing 1	spectrin repeat containing, nuclear envelope family member 4; Contributes to the establishment of secretory epithelial morphology by promoting kinesin-dependent apical migration of the centrosome and Golgi apparatus and basal localization of the nucleus (By similarity)	0.532
ANKLE1	TMEM43	ENSP00000377971	ENSP00000303992	ankyrin repeat and LEM domain containing 1	transmembrane protein 43; May have an important role in maintaining nuclear envelope structure by organizing protein complexes at the inner nuclear membrane. Required for retaining emerin at the inner nuclear membrane (By similarity)	0.592
ANKLE1	TMPO	ENSP00000377971	ENSP00000266732	ankyrin repeat and LEM domain containing 1	thymopoietin; May help direct the assembly of the nuclear lamina and thereby help maintain the structural organization of the nuclear envelope. Possible receptor for attachment of lamin filaments to the inner nuclear membrane. May be involved in the control of initiation of DNA replication through its interaction with NAKAP95	0.451
ANKLE1	UBC	ENSP00000377971	ENSP00000344818	ankyrin repeat and LEM domain containing 1	ubiquitin C	0.483
ANKLE2	ANKLE1	ENSP00000350686	ENSP00000377971	ankyrin repeat and LEM domain containing 2; Involved in mitotic nuclear envelope reassembly by promoting dephosphorylation of BAF/BANF1 during mitotic exit. Coordinates the control of BAF/BANF1 dephosphorylation by inhibiting VRK1 kinase and promoting dephosphorylation of BAF/BANF1 by protein phosphatase 2A (PP2A), thereby facilitating nuclear envelope assembly. It is unclear whether it acts as a real PP2A regulatory subunit or whether it is involved in recruitment of the PP2A complex	ankyrin repeat and LEM domain containing 1	0.882
ANKLE2	LEMD2	ENSP00000350686	ENSP00000293760	ankyrin repeat and LEM domain containing 2; Involved in mitotic nuclear envelope reassembly by promoting dephosphorylation of BAF/BANF1 during mitotic exit. Coordinates the control of BAF/BANF1 dephosphorylation by inhibiting VRK1 kinase and promoting dephosphorylation of BAF/BANF1 by protein phosphatase 2A (PP2A), thereby facilitating nuclear envelope assembly. It is unclear whether it acts as a real PP2A regulatory subunit or whether it is involved in recruitment of the PP2A complex	LEM domain containing 2; Involved in nuclear structure organization	0.543
ANKLE2	LEMD3	ENSP00000350686	ENSP00000308369	ankyrin repeat and LEM domain containing 2; Involved in mitotic nuclear envelope reassembly by promoting dephosphorylation of BAF/BANF1 during mitotic exit. Coordinates the control of BAF/BANF1 dephosphorylation by inhibiting VRK1 kinase and promoting dephosphorylation of BAF/BANF1 by protein phosphatase 2A (PP2A), thereby facilitating nuclear envelope assembly. It is unclear whether it acts as a real PP2A regulatory subunit or whether it is involved in recruitment of the PP2A complex	LEM domain containing 3; Can function as a specific repressor of TGF-beta, activin, and BMP signaling through its interaction with the R-SMAD proteins. Antagonizes TGF-beta-induced cell proliferation arrest	0.488
ANKLE2	SYNE4	ENSP00000350686	ENSP00000316130	ankyrin repeat and LEM domain containing 2; Involved in mitotic nuclear envelope reassembly by promoting dephosphorylation of BAF/BANF1 during mitotic exit. Coordinates the control of BAF/BANF1 dephosphorylation by inhibiting VRK1 kinase and promoting dephosphorylation of BAF/BANF1 by protein phosphatase 2A (PP2A), thereby facilitating nuclear envelope assembly. It is unclear whether it acts as a real PP2A regulatory subunit or whether it is involved in recruitment of the PP2A complex	spectrin repeat containing, nuclear envelope family member 4; Contributes to the establishment of secretory epithelial morphology by promoting kinesin-dependent apical migration of the centrosome and Golgi apparatus and basal localization of the nucleus (By similarity)	0.478
ANKLE2	TMEM43	ENSP00000350686	ENSP00000303992	ankyrin repeat and LEM domain containing 2; Involved in mitotic nuclear envelope reassembly by promoting dephosphorylation of BAF/BANF1 during mitotic exit. Coordinates the control of BAF/BANF1 dephosphorylation by inhibiting VRK1 kinase and promoting dephosphorylation of BAF/BANF1 by protein phosphatase 2A (PP2A), thereby facilitating nuclear envelope assembly. It is unclear whether it acts as a real PP2A regulatory subunit or whether it is involved in recruitment of the PP2A complex	transmembrane protein 43; May have an important role in maintaining nuclear envelope structure by organizing protein complexes at the inner nuclear membrane. Required for retaining emerin at the inner nuclear membrane (By similarity)	0.486
ANKLE2	UBC	ENSP00000350686	ENSP00000344818	ankyrin repeat and LEM domain containing 2; Involved in mitotic nuclear envelope reassembly by promoting dephosphorylation of BAF/BANF1 during mitotic exit. Coordinates the control of BAF/BANF1 dephosphorylation by inhibiting VRK1 kinase and promoting dephosphorylation of BAF/BANF1 by protein phosphatase 2A (PP2A), thereby facilitating nuclear envelope assembly. It is unclear whether it acts as a real PP2A regulatory subunit or whether it is involved in recruitment of the PP2A complex	ubiquitin C	0.483
LEMD2	ANKLE1	ENSP00000293760	ENSP00000377971	LEM domain containing 2; Involved in nuclear structure organization	ankyrin repeat and LEM domain containing 1	0.818
LEMD2	ANKLE2	ENSP00000293760	ENSP00000350686	LEM domain containing 2; Involved in nuclear structure organization	ankyrin repeat and LEM domain containing 2; Involved in mitotic nuclear envelope reassembly by promoting dephosphorylation of BAF/BANF1 during mitotic exit. Coordinates the control of BAF/BANF1 dephosphorylation by inhibiting VRK1 kinase and promoting dephosphorylation of BAF/BANF1 by protein phosphatase 2A (PP2A), thereby facilitating nuclear envelope assembly. It is unclear whether it acts as a real PP2A regulatory subunit or whether it is involved in recruitment of the PP2A complex	0.543
LEMD3	ANKLE1	ENSP00000308369	ENSP00000377971	LEM domain containing 3; Can function as a specific repressor of TGF-beta, activin, and BMP signaling through its interaction with the R-SMAD proteins. Antagonizes TGF-beta-induced cell proliferation arrest	ankyrin repeat and LEM domain containing 1	0.812
LEMD3	ANKLE2	ENSP00000308369	ENSP00000350686	LEM domain containing 3; Can function as a specific repressor of TGF-beta, activin, and BMP signaling through its interaction with the R-SMAD proteins. Antagonizes TGF-beta-induced cell proliferation arrest	ankyrin repeat and LEM domain containing 2; Involved in mitotic nuclear envelope reassembly by promoting dephosphorylation of BAF/BANF1 during mitotic exit. Coordinates the control of BAF/BANF1 dephosphorylation by inhibiting VRK1 kinase and promoting dephosphorylation of BAF/BANF1 by protein phosphatase 2A (PP2A), thereby facilitating nuclear envelope assembly. It is unclear whether it acts as a real PP2A regulatory subunit or whether it is involved in recruitment of the PP2A complex	0.488

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