node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABHD4 | PNPLA1 | ENSP00000414558 | ENSP00000378072 | abhydrolase domain containing 4; Lysophospholipase selective for N-acyl phosphatidylethanolamine (NAPE). Contributes to the biosynthesis of N-acyl ethanolamines, including the endocannabinoid anandamide by hydrolyzing the sn-1 and sn-2 acyl chains from N-acyl phosphatidylethanolamine (NAPE) generating glycerophospho-N-acyl ethanolamine (GP-NAE), an intermediate for N-acyl ethanolamine biosynthesis. Hydrolyzes substrates bearing saturated, monounsaturated, polyunsaturated N-acyl chains. Shows no significant activity towards other lysophospholipids, including lysophosphatidylcholine, lys [...] | patatin-like phospholipase domain containing 1; Lipid hydrolase (By similarity) | 0.535 |
ABHD5 | PNPLA1 | ENSP00000390849 | ENSP00000378072 | abhydrolase domain containing 5; Lysophosphatidic acid acyltransferase which functions in phosphatidic acid biosynthesis. May regulate the cellular storage of triacylglycerol through activation of the phospholipase PNPLA2. Involved in keratinocyte differentiation | patatin-like phospholipase domain containing 1; Lipid hydrolase (By similarity) | 0.744 |
FAM83F | PNPLA1 | ENSP00000330432 | ENSP00000378072 | family with sequence similarity 83, member F | patatin-like phospholipase domain containing 1; Lipid hydrolase (By similarity) | 0.725 |
FAM83F | THEM5 | ENSP00000330432 | ENSP00000357807 | family with sequence similarity 83, member F | thioesterase superfamily member 5; Has acyl-CoA thioesterase activity towards long-chain (C16 and C18) fatty acyl-CoA substrates, with a preference for linoleyl-CoA and other unsaturated long-chain fatty acid-CoA esters. Plays an important role in mitochondrial fatty acid metabolism, and in remodeling of the mitochondrial lipid cardiolipin. Required for normal mitochondrial function | 0.651 |
P85B | PIK3R2 | ENSP00000471914 | ENSP00000222254 | PIK3R2 protein ; Binds to activated (phosphorylated) protein-tyrosine kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane | phosphoinositide-3-kinase, regulatory subunit 2 (beta); Binds to activated (phosphorylated) protein-tyrosine kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane | 0.625 |
P85B | PNPLA1 | ENSP00000471914 | ENSP00000378072 | PIK3R2 protein ; Binds to activated (phosphorylated) protein-tyrosine kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane | patatin-like phospholipase domain containing 1; Lipid hydrolase (By similarity) | 0.516 |
PIK3R2 | P85B | ENSP00000222254 | ENSP00000471914 | phosphoinositide-3-kinase, regulatory subunit 2 (beta); Binds to activated (phosphorylated) protein-tyrosine kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane | PIK3R2 protein ; Binds to activated (phosphorylated) protein-tyrosine kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane | 0.625 |
PIK3R2 | PNPLA1 | ENSP00000222254 | ENSP00000378072 | phosphoinositide-3-kinase, regulatory subunit 2 (beta); Binds to activated (phosphorylated) protein-tyrosine kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane | patatin-like phospholipase domain containing 1; Lipid hydrolase (By similarity) | 0.522 |
PLA2G6 | PNPLA1 | ENSP00000333142 | ENSP00000378072 | phospholipase A2, group VI (cytosolic, calcium-independent); Catalyzes the release of fatty acids from phospholipids. It has been implicated in normal phospholipid remodeling, nitric oxide-induced or vasopressin-induced arachidonic acid release and in leukotriene and prostaglandin production. May participate in fas mediated apoptosis and in regulating transmembrane ion flux in glucose-stimulated B-cells. Has a role in cardiolipin (CL) deacylation. Required for both speed and directionality of monocyte MCP1/CCL2-induced chemotaxis through regulation of F- actin polymerization at the pse [...] | patatin-like phospholipase domain containing 1; Lipid hydrolase (By similarity) | 0.678 |
PLA2G6 | PNPLA6 | ENSP00000333142 | ENSP00000407509 | phospholipase A2, group VI (cytosolic, calcium-independent); Catalyzes the release of fatty acids from phospholipids. It has been implicated in normal phospholipid remodeling, nitric oxide-induced or vasopressin-induced arachidonic acid release and in leukotriene and prostaglandin production. May participate in fas mediated apoptosis and in regulating transmembrane ion flux in glucose-stimulated B-cells. Has a role in cardiolipin (CL) deacylation. Required for both speed and directionality of monocyte MCP1/CCL2-induced chemotaxis through regulation of F- actin polymerization at the pse [...] | patatin-like phospholipase domain containing 6; Phospholipase B that deacylates intracellular phosphatidylcholine (PtdCho), generating glycerophosphocholine (GroPtdCho). This deacylation occurs at both sn-2 and sn-1 positions of PtdCho. Its specific chemical modification by certain organophosphorus (OP) compounds leads to distal axonopathy | 0.975 |
PLA2G6 | PNPLA7 | ENSP00000333142 | ENSP00000384610 | phospholipase A2, group VI (cytosolic, calcium-independent); Catalyzes the release of fatty acids from phospholipids. It has been implicated in normal phospholipid remodeling, nitric oxide-induced or vasopressin-induced arachidonic acid release and in leukotriene and prostaglandin production. May participate in fas mediated apoptosis and in regulating transmembrane ion flux in glucose-stimulated B-cells. Has a role in cardiolipin (CL) deacylation. Required for both speed and directionality of monocyte MCP1/CCL2-induced chemotaxis through regulation of F- actin polymerization at the pse [...] | patatin-like phospholipase domain containing 7 | 0.970 |
PNPLA1 | ABHD4 | ENSP00000378072 | ENSP00000414558 | patatin-like phospholipase domain containing 1; Lipid hydrolase (By similarity) | abhydrolase domain containing 4; Lysophospholipase selective for N-acyl phosphatidylethanolamine (NAPE). Contributes to the biosynthesis of N-acyl ethanolamines, including the endocannabinoid anandamide by hydrolyzing the sn-1 and sn-2 acyl chains from N-acyl phosphatidylethanolamine (NAPE) generating glycerophospho-N-acyl ethanolamine (GP-NAE), an intermediate for N-acyl ethanolamine biosynthesis. Hydrolyzes substrates bearing saturated, monounsaturated, polyunsaturated N-acyl chains. Shows no significant activity towards other lysophospholipids, including lysophosphatidylcholine, lys [...] | 0.535 |
PNPLA1 | ABHD5 | ENSP00000378072 | ENSP00000390849 | patatin-like phospholipase domain containing 1; Lipid hydrolase (By similarity) | abhydrolase domain containing 5; Lysophosphatidic acid acyltransferase which functions in phosphatidic acid biosynthesis. May regulate the cellular storage of triacylglycerol through activation of the phospholipase PNPLA2. Involved in keratinocyte differentiation | 0.744 |
PNPLA1 | FAM83F | ENSP00000378072 | ENSP00000330432 | patatin-like phospholipase domain containing 1; Lipid hydrolase (By similarity) | family with sequence similarity 83, member F | 0.725 |
PNPLA1 | P85B | ENSP00000378072 | ENSP00000471914 | patatin-like phospholipase domain containing 1; Lipid hydrolase (By similarity) | PIK3R2 protein ; Binds to activated (phosphorylated) protein-tyrosine kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane | 0.516 |
PNPLA1 | PIK3R2 | ENSP00000378072 | ENSP00000222254 | patatin-like phospholipase domain containing 1; Lipid hydrolase (By similarity) | phosphoinositide-3-kinase, regulatory subunit 2 (beta); Binds to activated (phosphorylated) protein-tyrosine kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane | 0.522 |
PNPLA1 | PLA2G6 | ENSP00000378072 | ENSP00000333142 | patatin-like phospholipase domain containing 1; Lipid hydrolase (By similarity) | phospholipase A2, group VI (cytosolic, calcium-independent); Catalyzes the release of fatty acids from phospholipids. It has been implicated in normal phospholipid remodeling, nitric oxide-induced or vasopressin-induced arachidonic acid release and in leukotriene and prostaglandin production. May participate in fas mediated apoptosis and in regulating transmembrane ion flux in glucose-stimulated B-cells. Has a role in cardiolipin (CL) deacylation. Required for both speed and directionality of monocyte MCP1/CCL2-induced chemotaxis through regulation of F- actin polymerization at the pse [...] | 0.678 |
PNPLA1 | PNPLA6 | ENSP00000378072 | ENSP00000407509 | patatin-like phospholipase domain containing 1; Lipid hydrolase (By similarity) | patatin-like phospholipase domain containing 6; Phospholipase B that deacylates intracellular phosphatidylcholine (PtdCho), generating glycerophosphocholine (GroPtdCho). This deacylation occurs at both sn-2 and sn-1 positions of PtdCho. Its specific chemical modification by certain organophosphorus (OP) compounds leads to distal axonopathy | 0.684 |
PNPLA1 | PNPLA7 | ENSP00000378072 | ENSP00000384610 | patatin-like phospholipase domain containing 1; Lipid hydrolase (By similarity) | patatin-like phospholipase domain containing 7 | 0.653 |
PNPLA1 | PNPLA8 | ENSP00000378072 | ENSP00000257694 | patatin-like phospholipase domain containing 1; Lipid hydrolase (By similarity) | patatin-like phospholipase domain containing 8 | 0.811 |