node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
C3 | C4A | ENSP00000245907 | ENSP00000396688 | complement component 3; C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates | complement component 4A (Rodgers blood group) | 0.919 |
C3 | C4BPA | ENSP00000245907 | ENSP00000356037 | complement component 3; C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates | complement component 4 binding protein, alpha; Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. Alpha chain binds C4b. It interacts also with anticoagulant protein S and with serum amyloid P component | 0.680 |
C3 | CD46 | ENSP00000245907 | ENSP00000313875 | complement component 3; C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates | CD46 molecule, complement regulatory protein | 0.998 |
C3 | CFB | ENSP00000245907 | ENSP00000416561 | complement component 3; C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates | complement factor B | 0.990 |
C3 | CFH | ENSP00000245907 | ENSP00000356399 | complement component 3; C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates | complement factor H | 0.999 |
C3 | CFI | ENSP00000245907 | ENSP00000378130 | complement component 3; C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates | complement factor I; Responsible for cleaving the alpha-chains of C4b and C3b in the presence of the cofactors C4-binding protein and factor H respectively | 0.997 |
C3 | CFP | ENSP00000245907 | ENSP00000247153 | complement component 3; C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates | complement factor properdin; A positive regulator of the alternate pathway of complement. It binds to and stabilizes the C3- and C5-convertase enzyme complexes | 0.992 |
C3 | CR1 | ENSP00000245907 | ENSP00000356016 | complement component 3; C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates | complement component (3b/4b) receptor 1 (Knops blood group); Mediates cellular binding of particles and immune complexes that have activated complement | 0.998 |
C4A | C3 | ENSP00000396688 | ENSP00000245907 | complement component 4A (Rodgers blood group) | complement component 3; C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates | 0.919 |
C4A | C4BPA | ENSP00000396688 | ENSP00000356037 | complement component 4A (Rodgers blood group) | complement component 4 binding protein, alpha; Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. Alpha chain binds C4b. It interacts also with anticoagulant protein S and with serum amyloid P component | 0.908 |
C4A | C4BPB | ENSP00000396688 | ENSP00000243611 | complement component 4A (Rodgers blood group) | complement component 4 binding protein, beta; Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. It also interacts with anticoagulant protein S and with serum amyloid P component. The beta chain binds protein S | 0.907 |
C4A | CD46 | ENSP00000396688 | ENSP00000313875 | complement component 4A (Rodgers blood group) | CD46 molecule, complement regulatory protein | 0.907 |
C4A | CFB | ENSP00000396688 | ENSP00000416561 | complement component 4A (Rodgers blood group) | complement factor B | 0.648 |
C4A | CFI | ENSP00000396688 | ENSP00000378130 | complement component 4A (Rodgers blood group) | complement factor I; Responsible for cleaving the alpha-chains of C4b and C3b in the presence of the cofactors C4-binding protein and factor H respectively | 0.900 |
C4A | CFP | ENSP00000396688 | ENSP00000247153 | complement component 4A (Rodgers blood group) | complement factor properdin; A positive regulator of the alternate pathway of complement. It binds to and stabilizes the C3- and C5-convertase enzyme complexes | 0.508 |
C4A | CR1 | ENSP00000396688 | ENSP00000356016 | complement component 4A (Rodgers blood group) | complement component (3b/4b) receptor 1 (Knops blood group); Mediates cellular binding of particles and immune complexes that have activated complement | 0.980 |
C4BPA | C3 | ENSP00000356037 | ENSP00000245907 | complement component 4 binding protein, alpha; Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. Alpha chain binds C4b. It interacts also with anticoagulant protein S and with serum amyloid P component | complement component 3; C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates | 0.680 |
C4BPA | C4A | ENSP00000356037 | ENSP00000396688 | complement component 4 binding protein, alpha; Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. Alpha chain binds C4b. It interacts also with anticoagulant protein S and with serum amyloid P component | complement component 4A (Rodgers blood group) | 0.908 |
C4BPA | C4BPB | ENSP00000356037 | ENSP00000243611 | complement component 4 binding protein, alpha; Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. Alpha chain binds C4b. It interacts also with anticoagulant protein S and with serum amyloid P component | complement component 4 binding protein, beta; Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. It also interacts with anticoagulant protein S and with serum amyloid P component. The beta chain binds protein S | 0.923 |
C4BPA | CFI | ENSP00000356037 | ENSP00000378130 | complement component 4 binding protein, alpha; Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. Alpha chain binds C4b. It interacts also with anticoagulant protein S and with serum amyloid P component | complement factor I; Responsible for cleaving the alpha-chains of C4b and C3b in the presence of the cofactors C4-binding protein and factor H respectively | 0.923 |