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STRINGSTRING
C9 C9 CD46 CD46 CR1 CR1 CFH CFH CFI CFI C3 C3 C4BPA C4BPA C4A C4A CFB CFB CFP CFP C4BPB C4BPB
"CFI" - complement factor I in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
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[Homology]
Score
CFIcomplement factor I; Responsible for cleaving the alpha-chains of C4b and C3b in the presence of the cofactors C4-binding protein and factor H respectively (583 aa)    
Predicted Functional Partners:
C3
complement component 3; C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates (1663 aa)
        score_image score_image score_image   0.997
CFH
complement factor H (1231 aa)
        score_image score_image score_image   0.984
CD46
CD46 molecule, complement regulatory protein (399 aa)
          score_image score_image   0.949
C4BPA
complement component 4 binding protein, alpha; Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. Alpha chain binds C4b. It interacts also with anticoagulant protein S and with serum amyloid P component (597 aa)
      score_image   score_image score_image   0.923
CR1
complement component (3b/4b) receptor 1 (Knops blood group); Mediates cellular binding of particles and immune complexes that have activated complement (2489 aa)
          score_image score_image   0.916
C4A
complement component 4A (Rodgers blood group) (1744 aa)
          score_image     0.900
C4BPB
complement component 4 binding protein, beta; Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. It also interacts with anticoagulant protein S and with serum amyloid P component. The beta chain binds protein S (252 aa)
          score_image     0.900
C9
complement component 9; Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C9 is the pore-forming subunit of the MAC (559 aa)
      score_image     score_image   0.610
CFP
complement factor properdin; A positive regulator of the alternate pathway of complement. It binds to and stabilizes the C3- and C5-convertase enzyme complexes (469 aa)
            score_image   0.538
CFB
complement factor B (764 aa)
            score_image   0.493
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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