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NGDN NGDN VSX1 VSX1 HAND2 HAND2 SMYD1 SMYD1 MNX1 MNX1 SHH SHH IRX5 IRX5 KCND2 KCND2 PBX1 PBX1 KCNE4 KCNE4 GPD1L GPD1L
"IRX5" - iroquois homeobox 5 in Homo sapiens
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IRX5iroquois homeobox 5; Establishes the cardiac repolarization gradient by its repressive actions on the KCND2 potassium-channel gene. Required for retinal cone bipolar cell differentiation. May regulate contrast adaptation in the retina and control specific aspects of visual function in circuits of the mammalian retina (By similarity). Could be involved in the regulation of both the cell cycle and apoptosis in prostate cancer cells. Involved in craniofacial and gonadal development. Modulates the migration of progenitor cell populations in branchial arches and gonads by repressing CXCL12 (483 aa)    
Predicted Functional Partners:
KCND2
potassium voltage-gated channel, Shal-related subfamily, member 2; Pore-forming (alpha) subunit of voltage-gated rapidly inactivating A-type potassium channels. May contribute to I(To) current in heart and I(Sa) current in neurons. Channel properties are modulated by interactions with other alpha subunits and with regulatory subunits (630 aa)
            score_image   0.962
SHH
sonic hedgehog; Binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. In the absence of SHH, PTC represses the constitutive signaling activity of SMO. Also regulates another target, the gli oncogene. Intercellular signal essential for a variety of patterning events during development- signal produced by the notochord that induces ventral cell fate in the neural tube and somites, and the polarizing signal for patterning of the anterior-posterior axis of the developing limb bud. Displays both floor plate- [...] (462 aa)
            score_image   0.842
SMYD1
SET and MYND domain containing 1; Methylates histone H3 at ’Lys-4’ (H3K4me), seems able to perform both mono-, di-, and trimethylation. Acts as a transcriptional repressor. Essential for cardiomyocyte differentiation and cardiac morphogenesis (490 aa)
        score_image   score_image   0.759
MNX1
motor neuron and pancreas homeobox 1; Putative transcription factor involved in pancreas development and function (401 aa)
        score_image   score_image   0.694
GPD1L
glycerol-3-phosphate dehydrogenase 1-like; Plays a role in regulating cardiac sodium current; decreased enzymatic activity with resulting increased levels of glycerol 3-phosphate activating the DPD1L-dependent SCN5A phosphorylation pathway, may ultimately lead to decreased sodium current; cardiac sodium current may also be reduced due to alterations of NAD(H) balance induced by DPD1L (351 aa)
            score_image   0.659
KCNE4
potassium voltage-gated channel, Isk-related family, member 4; Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. May associate with KCNQ1/KVLTQ1 and inhibit potassium current (170 aa)
            score_image   0.656
VSX1
visual system homeobox 1 (365 aa)
            score_image   0.636
PBX1
pre-B-cell leukemia homeobox 1; Binds the sequence 5’-ATCAATCAA-3’. Acts as a transcriptional activator of PF4 in complex with MEIS1. Converted into a potent transcriptional activator by the (1;19) translocation. May have a role in steroidogenesis and, subsequently, sexual development and differentiation. Isoform PBX1b as part of a PDX1-PBX1b-MEIS2b complex in pancreatic acinar cells is involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element [...] (430 aa)
        score_image   score_image   0.597
NGDN
neuroguidin, EIF4E binding protein; Involved in the translational repression of cytoplasmic polyadenylation element (CPE)-containing mRNAs (By similarity) (315 aa)
            score_image   0.593
HAND2
heart and neural crest derivatives expressed 2; Essential for cardiac morphogenesis, particularly for the formation of the right ventricle and of the aortic arch arteries. Required for vascular development and regulation of angiogenesis, possibly through a VEGF signaling pathway. Plays also an important role in limb development, particularly in the establishment of anterior-posterior polarization, acting as an upstream regulator of sonic hedgehog (SHH) induction in the limb bud. Is involved in the development of branchial arches, which give rise to unique structures in the head and nec [...] (217 aa)
            score_image   0.591
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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