node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACO2 | ACSS1 | ENSP00000216254 | ENSP00000316924 | aconitase 2, mitochondrial; Catalyzes the isomerization of citrate to isocitrate via cis-aconitate (By similarity) | acyl-CoA synthetase short-chain family member 1 | 0.501 |
ACO2 | ACYP2 | ENSP00000216254 | ENSP00000378161 | aconitase 2, mitochondrial; Catalyzes the isomerization of citrate to isocitrate via cis-aconitate (By similarity) | acylphosphatase 2, muscle type; Its physiological role is not yet clear | 0.603 |
ACOT12 | ACSS1 | ENSP00000303246 | ENSP00000316924 | acyl-CoA thioesterase 12; Hydrolyzes acetyl-CoA to acetate and CoA | acyl-CoA synthetase short-chain family member 1 | 0.900 |
ACOT12 | ACSS2 | ENSP00000303246 | ENSP00000253382 | acyl-CoA thioesterase 12; Hydrolyzes acetyl-CoA to acetate and CoA | acyl-CoA synthetase short-chain family member 2; Activates acetate so that it can be used for lipid synthesis or for energy generation | 0.900 |
ACOT12 | ACYP2 | ENSP00000303246 | ENSP00000378161 | acyl-CoA thioesterase 12; Hydrolyzes acetyl-CoA to acetate and CoA | acylphosphatase 2, muscle type; Its physiological role is not yet clear | 0.900 |
ACOT12 | ALDH1B1 | ENSP00000303246 | ENSP00000366927 | acyl-CoA thioesterase 12; Hydrolyzes acetyl-CoA to acetate and CoA | aldehyde dehydrogenase 1 family, member B1; ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde. They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation | 0.911 |
ACOT12 | ALDH3A2 | ENSP00000303246 | ENSP00000345774 | acyl-CoA thioesterase 12; Hydrolyzes acetyl-CoA to acetate and CoA | aldehyde dehydrogenase 3 family, member A2; Catalyzes the oxidation of long-chain aliphatic aldehydes to fatty acids. Active on a variety of saturated and unsaturated aliphatic aldehydes between 6 and 24 carbons in length. Responsible for conversion of the sphingosine 1-phosphate (S1P) degradation product hexadecenal to hexadecenoic acid | 0.908 |
ACOT12 | ALDH7A1 | ENSP00000303246 | ENSP00000387123 | acyl-CoA thioesterase 12; Hydrolyzes acetyl-CoA to acetate and CoA | aldehyde dehydrogenase 7 family, member A1; Multifunctional enzyme mediating important protective effects. Metabolizes betaine aldehyde to betaine, an important cellular osmolyte and methyl donor. Protects cells from oxidative stress by metabolizing a number of lipid peroxidation-derived aldehydes. Involved in lysine catabolism | 0.900 |
ACOT12 | ALDH9A1 | ENSP00000303246 | ENSP00000346827 | acyl-CoA thioesterase 12; Hydrolyzes acetyl-CoA to acetate and CoA | aldehyde dehydrogenase 9 family, member A1; Converts gamma-trimethylaminobutyraldehyde into gamma- butyrobetaine. Catalyzes the irreversible oxidation of a broad range of aldehydes to the corresponding acids in an NAD-dependent reaction | 0.900 |
ACOT12 | ENSG00000257767 | ENSP00000303246 | ENSP00000450353 | acyl-CoA thioesterase 12; Hydrolyzes acetyl-CoA to acetate and CoA | Uncharacterized protein | 0.900 |
ACSS1 | ACO2 | ENSP00000316924 | ENSP00000216254 | acyl-CoA synthetase short-chain family member 1 | aconitase 2, mitochondrial; Catalyzes the isomerization of citrate to isocitrate via cis-aconitate (By similarity) | 0.501 |
ACSS1 | ACOT12 | ENSP00000316924 | ENSP00000303246 | acyl-CoA synthetase short-chain family member 1 | acyl-CoA thioesterase 12; Hydrolyzes acetyl-CoA to acetate and CoA | 0.900 |
ACSS1 | ACSS2 | ENSP00000316924 | ENSP00000253382 | acyl-CoA synthetase short-chain family member 1 | acyl-CoA synthetase short-chain family member 2; Activates acetate so that it can be used for lipid synthesis or for energy generation | 0.907 |
ACSS1 | ACYP2 | ENSP00000316924 | ENSP00000378161 | acyl-CoA synthetase short-chain family member 1 | acylphosphatase 2, muscle type; Its physiological role is not yet clear | 0.900 |
ACSS1 | ALDH1B1 | ENSP00000316924 | ENSP00000366927 | acyl-CoA synthetase short-chain family member 1 | aldehyde dehydrogenase 1 family, member B1; ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde. They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation | 0.961 |
ACSS1 | ALDH3A2 | ENSP00000316924 | ENSP00000345774 | acyl-CoA synthetase short-chain family member 1 | aldehyde dehydrogenase 3 family, member A2; Catalyzes the oxidation of long-chain aliphatic aldehydes to fatty acids. Active on a variety of saturated and unsaturated aliphatic aldehydes between 6 and 24 carbons in length. Responsible for conversion of the sphingosine 1-phosphate (S1P) degradation product hexadecenal to hexadecenoic acid | 0.954 |
ACSS1 | ALDH7A1 | ENSP00000316924 | ENSP00000387123 | acyl-CoA synthetase short-chain family member 1 | aldehyde dehydrogenase 7 family, member A1; Multifunctional enzyme mediating important protective effects. Metabolizes betaine aldehyde to betaine, an important cellular osmolyte and methyl donor. Protects cells from oxidative stress by metabolizing a number of lipid peroxidation-derived aldehydes. Involved in lysine catabolism | 0.938 |
ACSS1 | ALDH9A1 | ENSP00000316924 | ENSP00000346827 | acyl-CoA synthetase short-chain family member 1 | aldehyde dehydrogenase 9 family, member A1; Converts gamma-trimethylaminobutyraldehyde into gamma- butyrobetaine. Catalyzes the irreversible oxidation of a broad range of aldehydes to the corresponding acids in an NAD-dependent reaction | 0.939 |
ACSS1 | ENSG00000257767 | ENSP00000316924 | ENSP00000450353 | acyl-CoA synthetase short-chain family member 1 | Uncharacterized protein | 0.939 |
ACSS2 | ACOT12 | ENSP00000253382 | ENSP00000303246 | acyl-CoA synthetase short-chain family member 2; Activates acetate so that it can be used for lipid synthesis or for energy generation | acyl-CoA thioesterase 12; Hydrolyzes acetyl-CoA to acetate and CoA | 0.900 |