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MEF2D MEF2D PPIA PPIA MEF2A MEF2A NFATC2 NFATC2 NFATC1 NFATC1 MEF2C MEF2C FKBP1A FKBP1A PPP3CA PPP3CA CABIN1 CABIN1 PPP3R1 PPP3R1 RCAN1 RCAN1
"PPP3CA" - protein phosphatase 3, catalytic subunit, alpha isozyme in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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protein of unknown 3D structure
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PPP3CAprotein phosphatase 3, catalytic subunit, alpha isozyme; Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin. Dephosphorylates DNM1L, HSPB1 and SSH1 (521 aa)    
Predicted Functional Partners:
PPP3R1
protein phosphatase 3, regulatory subunit B, alpha; Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity (170 aa)
    score_image score_image score_image score_image score_image   0.999
CABIN1
calcineurin binding protein 1; May be required for replication-independent chromatin assembly. May serve as a negative regulator of T-cell receptor (TCR) signaling via inhibition of calcineurin. Inhibition of activated calcineurin is dependent on both PKC and calcium signals (2220 aa)
        score_image score_image score_image   0.997
PPIA
peptidylprolyl isomerase A (cyclophilin A); PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity) (165 aa)
        score_image score_image score_image   0.996
RCAN1
regulator of calcineurin 1 (252 aa)
        score_image   score_image   0.994
FKBP1A
FK506 binding protein 1A, 12kDa; Keeps in an inactive conformation TGFBR1, the TGF-beta type I serine/threonine kinase receptor, preventing TGF-beta receptor activation in absence of ligand. Recruites SMAD7 to ACVR1B which prevents the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. May modulate the RYR1 calcium channel activity. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (108 aa)
        score_image score_image score_image   0.985
NFATC1
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1; Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 or IL-4 gene transcription. Also controls gene expression in embryonic cardiac cells. Could regulate not only the activation and proliferation but also the differentiation and programmed death of T-lymphocytes as well as lymphoid and non-lymphoid cells (930 aa)
        score_image score_image score_image   0.981
MEF2A
myocyte enhancer factor 2A (499 aa)
          score_image score_image   0.977
NFATC2
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 (925 aa)
        score_image score_image score_image   0.977
MEF2D
myocyte enhancer factor 2D; Transcriptional activator which binds specifically to the MEF2 element, 5’-YTA[AT](4)TAR-3’, found in numerous muscle- specific, growth factor- and stress-induced genes. Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival. Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription. Plays a critical role in the regulation of neuronal apoptosis (By similarity) (521 aa)
          score_image score_image   0.975
MEF2C
myocyte enhancer factor 2C; Transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle- specific genes. Controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. Plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission. Crucial for normal neuronal development, distribution, and electrical activity in the neocortex. Necessary for proper development of megakaryocytes and platel [...] (483 aa)
          score_image score_image   0.962
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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