| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ADAM2 | ADAM20 | ENSP00000265708 | ENSP00000256389 | ADAM metallopeptidase domain 2; Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. Could have a direct role in sperm-zona binding or migration of sperm from the uterus into the oviduct. Interactions with egg membrane could be mediated via binding between its disintegrin-like domain to one or more integrins receptors on the egg. This is a non catalytic metalloprotease-like protein | ADAM metallopeptidase domain 20; May be involved in sperm maturation and/or fertilization | 0.917 |
| ADAM2 | ADAM21 | ENSP00000265708 | ENSP00000267499 | ADAM metallopeptidase domain 2; Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. Could have a direct role in sperm-zona binding or migration of sperm from the uterus into the oviduct. Interactions with egg membrane could be mediated via binding between its disintegrin-like domain to one or more integrins receptors on the egg. This is a non catalytic metalloprotease-like protein | ADAM metallopeptidase domain 21; May be involved in sperm maturation and/or fertilization. May also be involved in epithelia functions associated with establishing and maintaining gradients of ions or nutrients | 0.914 |
| ADAM2 | ADAM30 | ENSP00000265708 | ENSP00000358407 | ADAM metallopeptidase domain 2; Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. Could have a direct role in sperm-zona binding or migration of sperm from the uterus into the oviduct. Interactions with egg membrane could be mediated via binding between its disintegrin-like domain to one or more integrins receptors on the egg. This is a non catalytic metalloprotease-like protein | ADAM metallopeptidase domain 30; May be involved in spermatogenesis and fertilization | 0.908 |
| ADAM2 | B4GALT1 | ENSP00000265708 | ENSP00000369055 | ADAM metallopeptidase domain 2; Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. Could have a direct role in sperm-zona binding or migration of sperm from the uterus into the oviduct. Interactions with egg membrane could be mediated via binding between its disintegrin-like domain to one or more integrins receptors on the egg. This is a non catalytic metalloprotease-like protein | UDP-Gal-betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1 | 0.900 |
| ADAM2 | OVGP1 | ENSP00000265708 | ENSP00000358747 | ADAM metallopeptidase domain 2; Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. Could have a direct role in sperm-zona binding or migration of sperm from the uterus into the oviduct. Interactions with egg membrane could be mediated via binding between its disintegrin-like domain to one or more integrins receptors on the egg. This is a non catalytic metalloprotease-like protein | oviductal glycoprotein 1, 120kDa; Binds to oocyte zona pellucida in vivo. May play a role in the fertilization process and/or early embryonic development | 0.904 |
| ADAM2 | ZP1 | ENSP00000265708 | ENSP00000278853 | ADAM metallopeptidase domain 2; Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. Could have a direct role in sperm-zona binding or migration of sperm from the uterus into the oviduct. Interactions with egg membrane could be mediated via binding between its disintegrin-like domain to one or more integrins receptors on the egg. This is a non catalytic metalloprotease-like protein | zona pellucida glycoprotein 1 (sperm receptor); The mammalian zona pellucida, which mediates species- specific sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy, is composed of three to four glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP1 ensures the structural integrity of the zona pellucida | 0.904 |
| ADAM2 | ZP2 | ENSP00000265708 | ENSP00000219593 | ADAM metallopeptidase domain 2; Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. Could have a direct role in sperm-zona binding or migration of sperm from the uterus into the oviduct. Interactions with egg membrane could be mediated via binding between its disintegrin-like domain to one or more integrins receptors on the egg. This is a non catalytic metalloprotease-like protein | zona pellucida glycoprotein 2 (sperm receptor); The mammalian zona pellucida, which mediates species- specific sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy, is composed of three to four glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP2 may act as a secondary sperm receptor | 0.932 |
| ADAM2 | ZP3 | ENSP00000265708 | ENSP00000378326 | ADAM metallopeptidase domain 2; Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. Could have a direct role in sperm-zona binding or migration of sperm from the uterus into the oviduct. Interactions with egg membrane could be mediated via binding between its disintegrin-like domain to one or more integrins receptors on the egg. This is a non catalytic metalloprotease-like protein | zona pellucida glycoprotein 3 (sperm receptor); The mammalian zona pellucida, which mediates species- specific sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy, is composed of three to four glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP3 is essential for sperm binding and zona matrix formation | 0.923 |
| ADAM2 | ZP4 | ENSP00000265708 | ENSP00000355529 | ADAM metallopeptidase domain 2; Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. Could have a direct role in sperm-zona binding or migration of sperm from the uterus into the oviduct. Interactions with egg membrane could be mediated via binding between its disintegrin-like domain to one or more integrins receptors on the egg. This is a non catalytic metalloprotease-like protein | zona pellucida glycoprotein 4; The mammalian zona pellucida, which mediates species- specific sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy, is composed of three to four glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP4 may act as a sperm receptor | 0.905 |
| ADAM20 | ADAM2 | ENSP00000256389 | ENSP00000265708 | ADAM metallopeptidase domain 20; May be involved in sperm maturation and/or fertilization | ADAM metallopeptidase domain 2; Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. Could have a direct role in sperm-zona binding or migration of sperm from the uterus into the oviduct. Interactions with egg membrane could be mediated via binding between its disintegrin-like domain to one or more integrins receptors on the egg. This is a non catalytic metalloprotease-like protein | 0.917 |
| ADAM20 | ADAM21 | ENSP00000256389 | ENSP00000267499 | ADAM metallopeptidase domain 20; May be involved in sperm maturation and/or fertilization | ADAM metallopeptidase domain 21; May be involved in sperm maturation and/or fertilization. May also be involved in epithelia functions associated with establishing and maintaining gradients of ions or nutrients | 0.902 |
| ADAM20 | ADAM30 | ENSP00000256389 | ENSP00000358407 | ADAM metallopeptidase domain 20; May be involved in sperm maturation and/or fertilization | ADAM metallopeptidase domain 30; May be involved in spermatogenesis and fertilization | 0.908 |
| ADAM20 | B4GALT1 | ENSP00000256389 | ENSP00000369055 | ADAM metallopeptidase domain 20; May be involved in sperm maturation and/or fertilization | UDP-Gal-betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1 | 0.900 |
| ADAM20 | OVGP1 | ENSP00000256389 | ENSP00000358747 | ADAM metallopeptidase domain 20; May be involved in sperm maturation and/or fertilization | oviductal glycoprotein 1, 120kDa; Binds to oocyte zona pellucida in vivo. May play a role in the fertilization process and/or early embryonic development | 0.900 |
| ADAM20 | ZP1 | ENSP00000256389 | ENSP00000278853 | ADAM metallopeptidase domain 20; May be involved in sperm maturation and/or fertilization | zona pellucida glycoprotein 1 (sperm receptor); The mammalian zona pellucida, which mediates species- specific sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy, is composed of three to four glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP1 ensures the structural integrity of the zona pellucida | 0.900 |
| ADAM20 | ZP2 | ENSP00000256389 | ENSP00000219593 | ADAM metallopeptidase domain 20; May be involved in sperm maturation and/or fertilization | zona pellucida glycoprotein 2 (sperm receptor); The mammalian zona pellucida, which mediates species- specific sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy, is composed of three to four glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP2 may act as a secondary sperm receptor | 0.900 |
| ADAM20 | ZP3 | ENSP00000256389 | ENSP00000378326 | ADAM metallopeptidase domain 20; May be involved in sperm maturation and/or fertilization | zona pellucida glycoprotein 3 (sperm receptor); The mammalian zona pellucida, which mediates species- specific sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy, is composed of three to four glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP3 is essential for sperm binding and zona matrix formation | 0.902 |
| ADAM20 | ZP4 | ENSP00000256389 | ENSP00000355529 | ADAM metallopeptidase domain 20; May be involved in sperm maturation and/or fertilization | zona pellucida glycoprotein 4; The mammalian zona pellucida, which mediates species- specific sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy, is composed of three to four glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP4 may act as a sperm receptor | 0.900 |
| ADAM21 | ADAM2 | ENSP00000267499 | ENSP00000265708 | ADAM metallopeptidase domain 21; May be involved in sperm maturation and/or fertilization. May also be involved in epithelia functions associated with establishing and maintaining gradients of ions or nutrients | ADAM metallopeptidase domain 2; Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. Could have a direct role in sperm-zona binding or migration of sperm from the uterus into the oviduct. Interactions with egg membrane could be mediated via binding between its disintegrin-like domain to one or more integrins receptors on the egg. This is a non catalytic metalloprotease-like protein | 0.914 |
| ADAM21 | ADAM20 | ENSP00000267499 | ENSP00000256389 | ADAM metallopeptidase domain 21; May be involved in sperm maturation and/or fertilization. May also be involved in epithelia functions associated with establishing and maintaining gradients of ions or nutrients | ADAM metallopeptidase domain 20; May be involved in sperm maturation and/or fertilization | 0.902 |
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