node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ADH6 | ALDH1A1 | ENSP00000378359 | ENSP00000297785 | alcohol dehydrogenase 6 (class V) | aldehyde dehydrogenase 1 family, member A1; Binds free retinal and cellular retinol-binding protein- bound retinal. Can convert/oxidize retinaldehyde to retinoic acid (By similarity) | 0.964 |
ADH6 | ALDH1A3 | ENSP00000378359 | ENSP00000332256 | alcohol dehydrogenase 6 (class V) | aldehyde dehydrogenase 1 family, member A3; Recognizes as substrates free retinal and cellular retinol-binding protein-bound retinal. Seems to be the key enzyme in the formation of an RA gradient along the dorso-ventral axis during the early eye development and also in the development of the olfactory system (By similarity) | 0.949 |
ADH6 | ALDH1B1 | ENSP00000378359 | ENSP00000366927 | alcohol dehydrogenase 6 (class V) | aldehyde dehydrogenase 1 family, member B1; ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde. They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation | 0.975 |
ADH6 | ALDH3A1 | ENSP00000378359 | ENSP00000225740 | alcohol dehydrogenase 6 (class V) | aldehyde dehydrogenase 3 family, member A1; ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde. They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation. This protein preferentially oxidizes aromatic aldehyde substrates. It may play a role in the oxidation of toxic aldehydes | 0.955 |
ADH6 | ALDH3A2 | ENSP00000378359 | ENSP00000345774 | alcohol dehydrogenase 6 (class V) | aldehyde dehydrogenase 3 family, member A2; Catalyzes the oxidation of long-chain aliphatic aldehydes to fatty acids. Active on a variety of saturated and unsaturated aliphatic aldehydes between 6 and 24 carbons in length. Responsible for conversion of the sphingosine 1-phosphate (S1P) degradation product hexadecenal to hexadecenoic acid | 0.964 |
ADH6 | ALDH3B2 | ENSP00000378359 | ENSP00000255084 | alcohol dehydrogenase 6 (class V) | aldehyde dehydrogenase 3 family, member B2 | 0.964 |
ADH6 | ALDH9A1 | ENSP00000378359 | ENSP00000346827 | alcohol dehydrogenase 6 (class V) | aldehyde dehydrogenase 9 family, member A1; Converts gamma-trimethylaminobutyraldehyde into gamma- butyrobetaine. Catalyzes the irreversible oxidation of a broad range of aldehydes to the corresponding acids in an NAD-dependent reaction | 0.931 |
ADH6 | AOX1 | ENSP00000378359 | ENSP00000363832 | alcohol dehydrogenase 6 (class V) | aldehyde oxidase 1 | 0.948 |
ADH6 | COMT | ENSP00000378359 | ENSP00000354511 | alcohol dehydrogenase 6 (class V) | catechol-O-methyltransferase; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol | 0.929 |
ADH6 | CYP2E1 | ENSP00000378359 | ENSP00000252945 | alcohol dehydrogenase 6 (class V) | cytochrome P450, family 2, subfamily E, polypeptide 1; Metabolizes several precarcinogens, drugs, and solvents to reactive metabolites. Inactivates a number of drugs and xenobiotics and also bioactivates many xenobiotic substrates to their hepatotoxic or carcinogenic forms | 0.925 |
ALDH1A1 | ADH6 | ENSP00000297785 | ENSP00000378359 | aldehyde dehydrogenase 1 family, member A1; Binds free retinal and cellular retinol-binding protein- bound retinal. Can convert/oxidize retinaldehyde to retinoic acid (By similarity) | alcohol dehydrogenase 6 (class V) | 0.964 |
ALDH1A1 | CYP2E1 | ENSP00000297785 | ENSP00000252945 | aldehyde dehydrogenase 1 family, member A1; Binds free retinal and cellular retinol-binding protein- bound retinal. Can convert/oxidize retinaldehyde to retinoic acid (By similarity) | cytochrome P450, family 2, subfamily E, polypeptide 1; Metabolizes several precarcinogens, drugs, and solvents to reactive metabolites. Inactivates a number of drugs and xenobiotics and also bioactivates many xenobiotic substrates to their hepatotoxic or carcinogenic forms | 0.506 |
ALDH1A3 | ADH6 | ENSP00000332256 | ENSP00000378359 | aldehyde dehydrogenase 1 family, member A3; Recognizes as substrates free retinal and cellular retinol-binding protein-bound retinal. Seems to be the key enzyme in the formation of an RA gradient along the dorso-ventral axis during the early eye development and also in the development of the olfactory system (By similarity) | alcohol dehydrogenase 6 (class V) | 0.949 |
ALDH1A3 | COMT | ENSP00000332256 | ENSP00000354511 | aldehyde dehydrogenase 1 family, member A3; Recognizes as substrates free retinal and cellular retinol-binding protein-bound retinal. Seems to be the key enzyme in the formation of an RA gradient along the dorso-ventral axis during the early eye development and also in the development of the olfactory system (By similarity) | catechol-O-methyltransferase; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol | 0.902 |
ALDH1A3 | CYP2E1 | ENSP00000332256 | ENSP00000252945 | aldehyde dehydrogenase 1 family, member A3; Recognizes as substrates free retinal and cellular retinol-binding protein-bound retinal. Seems to be the key enzyme in the formation of an RA gradient along the dorso-ventral axis during the early eye development and also in the development of the olfactory system (By similarity) | cytochrome P450, family 2, subfamily E, polypeptide 1; Metabolizes several precarcinogens, drugs, and solvents to reactive metabolites. Inactivates a number of drugs and xenobiotics and also bioactivates many xenobiotic substrates to their hepatotoxic or carcinogenic forms | 0.915 |
ALDH1B1 | ADH6 | ENSP00000366927 | ENSP00000378359 | aldehyde dehydrogenase 1 family, member B1; ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde. They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation | alcohol dehydrogenase 6 (class V) | 0.975 |
ALDH3A1 | ADH6 | ENSP00000225740 | ENSP00000378359 | aldehyde dehydrogenase 3 family, member A1; ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde. They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation. This protein preferentially oxidizes aromatic aldehyde substrates. It may play a role in the oxidation of toxic aldehydes | alcohol dehydrogenase 6 (class V) | 0.955 |
ALDH3A1 | COMT | ENSP00000225740 | ENSP00000354511 | aldehyde dehydrogenase 3 family, member A1; ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde. They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation. This protein preferentially oxidizes aromatic aldehyde substrates. It may play a role in the oxidation of toxic aldehydes | catechol-O-methyltransferase; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol | 0.901 |
ALDH3A1 | CYP2E1 | ENSP00000225740 | ENSP00000252945 | aldehyde dehydrogenase 3 family, member A1; ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde. They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation. This protein preferentially oxidizes aromatic aldehyde substrates. It may play a role in the oxidation of toxic aldehydes | cytochrome P450, family 2, subfamily E, polypeptide 1; Metabolizes several precarcinogens, drugs, and solvents to reactive metabolites. Inactivates a number of drugs and xenobiotics and also bioactivates many xenobiotic substrates to their hepatotoxic or carcinogenic forms | 0.913 |
ALDH3A2 | ADH6 | ENSP00000345774 | ENSP00000378359 | aldehyde dehydrogenase 3 family, member A2; Catalyzes the oxidation of long-chain aliphatic aldehydes to fatty acids. Active on a variety of saturated and unsaturated aliphatic aldehydes between 6 and 24 carbons in length. Responsible for conversion of the sphingosine 1-phosphate (S1P) degradation product hexadecenal to hexadecenoic acid | alcohol dehydrogenase 6 (class V) | 0.964 |