node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
DAK | ENO3 | ENSP00000378360 | ENSP00000324105 | dihydroxyacetone kinase 2 homolog (S. cerevisiae); Catalyzes both the phosphorylation of dihydroxyacetone and of glyceraldehyde, and the splitting of ribonucleoside diphosphate-X compounds among which FAD is the best substrate | enolase 3 (beta, muscle); Appears to have a function in striated muscle development and regeneration | 0.682 |
DAK | GNPAT | ENSP00000378360 | ENSP00000355607 | dihydroxyacetone kinase 2 homolog (S. cerevisiae); Catalyzes both the phosphorylation of dihydroxyacetone and of glyceraldehyde, and the splitting of ribonucleoside diphosphate-X compounds among which FAD is the best substrate | glyceronephosphate O-acyltransferase | 0.800 |
DAK | GPD1 | ENSP00000378360 | ENSP00000301149 | dihydroxyacetone kinase 2 homolog (S. cerevisiae); Catalyzes both the phosphorylation of dihydroxyacetone and of glyceraldehyde, and the splitting of ribonucleoside diphosphate-X compounds among which FAD is the best substrate | glycerol-3-phosphate dehydrogenase 1 (soluble) | 0.829 |
DAK | GPD1L | ENSP00000378360 | ENSP00000282541 | dihydroxyacetone kinase 2 homolog (S. cerevisiae); Catalyzes both the phosphorylation of dihydroxyacetone and of glyceraldehyde, and the splitting of ribonucleoside diphosphate-X compounds among which FAD is the best substrate | glycerol-3-phosphate dehydrogenase 1-like; Plays a role in regulating cardiac sodium current; decreased enzymatic activity with resulting increased levels of glycerol 3-phosphate activating the DPD1L-dependent SCN5A phosphorylation pathway, may ultimately lead to decreased sodium current; cardiac sodium current may also be reduced due to alterations of NAD(H) balance induced by DPD1L | 0.829 |
DAK | GPD2 | ENSP00000378360 | ENSP00000308610 | dihydroxyacetone kinase 2 homolog (S. cerevisiae); Catalyzes both the phosphorylation of dihydroxyacetone and of glyceraldehyde, and the splitting of ribonucleoside diphosphate-X compounds among which FAD is the best substrate | glycerol-3-phosphate dehydrogenase 2 (mitochondrial) | 0.867 |
DAK | IFIH1 | ENSP00000378360 | ENSP00000263642 | dihydroxyacetone kinase 2 homolog (S. cerevisiae); Catalyzes both the phosphorylation of dihydroxyacetone and of glyceraldehyde, and the splitting of ribonucleoside diphosphate-X compounds among which FAD is the best substrate | interferon induced with helicase C domain 1; Innate immune receptor which acts as a cytoplasmic sensor of viral nucleic acids and plays a major role in sensing viral infection and in the activation of a cascade of antiviral responses including the induction of type I interferons and proinflammatory cytokines. Its ligands include mRNA lacking 2’-O- methylation at their 5’ cap and long-dsRNA (>1 kb in length). Upon ligand binding it associates with mitochondria antiviral signaling protein (MAVS/IPS1) which activates the IKK-related kinases- TBK1 and IKBKE which phosphorylate interferon r [...] | 0.995 |
DAK | MAVS | ENSP00000378360 | ENSP00000401980 | dihydroxyacetone kinase 2 homolog (S. cerevisiae); Catalyzes both the phosphorylation of dihydroxyacetone and of glyceraldehyde, and the splitting of ribonucleoside diphosphate-X compounds among which FAD is the best substrate | mitochondrial antiviral signaling protein | 0.908 |
DAK | NLRC5 | ENSP00000378360 | ENSP00000262510 | dihydroxyacetone kinase 2 homolog (S. cerevisiae); Catalyzes both the phosphorylation of dihydroxyacetone and of glyceraldehyde, and the splitting of ribonucleoside diphosphate-X compounds among which FAD is the best substrate | NLR family, CARD domain containing 5 | 0.900 |
DAK | NLRX1 | ENSP00000378360 | ENSP00000292199 | dihydroxyacetone kinase 2 homolog (S. cerevisiae); Catalyzes both the phosphorylation of dihydroxyacetone and of glyceraldehyde, and the splitting of ribonucleoside diphosphate-X compounds among which FAD is the best substrate | NLR family member X1; Participates in antiviral signaling. Acts as a negative regulator of MAVS-mediated antiviral responses, through the inhibition of the virus-induced RLH (RIG-like helicase)-MAVS interaction (PubMed-18200010). Has no inhibitory function on NF- Kappa-B and type 1 interferon signaling pathways, but enhances NF- Kappa-B and JUN N-terminal kinase dependent signaling through the production of reactive oxygen species (PubMed-18219313) | 0.930 |
DAK | UBC | ENSP00000378360 | ENSP00000344818 | dihydroxyacetone kinase 2 homolog (S. cerevisiae); Catalyzes both the phosphorylation of dihydroxyacetone and of glyceraldehyde, and the splitting of ribonucleoside diphosphate-X compounds among which FAD is the best substrate | ubiquitin C | 0.868 |
ENO3 | DAK | ENSP00000324105 | ENSP00000378360 | enolase 3 (beta, muscle); Appears to have a function in striated muscle development and regeneration | dihydroxyacetone kinase 2 homolog (S. cerevisiae); Catalyzes both the phosphorylation of dihydroxyacetone and of glyceraldehyde, and the splitting of ribonucleoside diphosphate-X compounds among which FAD is the best substrate | 0.682 |
ENO3 | UBC | ENSP00000324105 | ENSP00000344818 | enolase 3 (beta, muscle); Appears to have a function in striated muscle development and regeneration | ubiquitin C | 0.901 |
GNPAT | DAK | ENSP00000355607 | ENSP00000378360 | glyceronephosphate O-acyltransferase | dihydroxyacetone kinase 2 homolog (S. cerevisiae); Catalyzes both the phosphorylation of dihydroxyacetone and of glyceraldehyde, and the splitting of ribonucleoside diphosphate-X compounds among which FAD is the best substrate | 0.800 |
GNPAT | GPD1 | ENSP00000355607 | ENSP00000301149 | glyceronephosphate O-acyltransferase | glycerol-3-phosphate dehydrogenase 1 (soluble) | 0.922 |
GNPAT | GPD1L | ENSP00000355607 | ENSP00000282541 | glyceronephosphate O-acyltransferase | glycerol-3-phosphate dehydrogenase 1-like; Plays a role in regulating cardiac sodium current; decreased enzymatic activity with resulting increased levels of glycerol 3-phosphate activating the DPD1L-dependent SCN5A phosphorylation pathway, may ultimately lead to decreased sodium current; cardiac sodium current may also be reduced due to alterations of NAD(H) balance induced by DPD1L | 0.917 |
GNPAT | GPD2 | ENSP00000355607 | ENSP00000308610 | glyceronephosphate O-acyltransferase | glycerol-3-phosphate dehydrogenase 2 (mitochondrial) | 0.922 |
GNPAT | UBC | ENSP00000355607 | ENSP00000344818 | glyceronephosphate O-acyltransferase | ubiquitin C | 0.721 |
GPD1 | DAK | ENSP00000301149 | ENSP00000378360 | glycerol-3-phosphate dehydrogenase 1 (soluble) | dihydroxyacetone kinase 2 homolog (S. cerevisiae); Catalyzes both the phosphorylation of dihydroxyacetone and of glyceraldehyde, and the splitting of ribonucleoside diphosphate-X compounds among which FAD is the best substrate | 0.829 |
GPD1 | GNPAT | ENSP00000301149 | ENSP00000355607 | glycerol-3-phosphate dehydrogenase 1 (soluble) | glyceronephosphate O-acyltransferase | 0.922 |
GPD1 | GPD2 | ENSP00000301149 | ENSP00000308610 | glycerol-3-phosphate dehydrogenase 1 (soluble) | glycerol-3-phosphate dehydrogenase 2 (mitochondrial) | 0.948 |