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STRINGSTRING
PTOV1 PTOV1 SORBS1 SORBS1 F2R F2R FLOT2 FLOT2 FRS2 FRS2 CAV1 CAV1 EGFR EGFR UBC UBC FYN FYN ERLIN2 ERLIN2 RAB2A RAB2A
"FLOT2" - flotillin 2 in Homo sapiens
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protein of unknown 3D structure
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FLOT2flotillin 2; May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles. May be involved in epidermal cell adhesion and epidermal structure and function (428 aa)    
Predicted Functional Partners:
FYN
FYN oncogene related to SRC, FGR, YES; Non-receptor tyrosine-protein kinase that plays a role in many biological processes including regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. Inactive FYN is phosphorylated on its C-terminal tail within the catalytic domain. Following activation by PKA, the protein subsequently associates with PTK2/FAK1, allowing PTK2/FAK1 phosphorylation, activation and targeting to focal adhesions. Involved in the regulation of cell adhesion and motilit [...] (537 aa)
        score_image   score_image   0.967
F2R
coagulation factor II (thrombin) receptor; High affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation and in vascular development (425 aa)
        score_image   score_image   0.957
ERLIN2
ER lipid raft associated 2; Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Also involved in ITPR1 degradation by the ERAD pathway (339 aa)
        score_image   score_image   0.949
CAV1
caveolin 1, caveolae protein, 22kDa; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)- mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3- dependent manner. Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway (178 aa)
        score_image   score_image   0.942
RAB2A
RAB2A, member RAS oncogene family; Required for protein transport from the endoplasmic reticulum to the Golgi complex (212 aa)
        score_image   score_image   0.903
UBC
ubiquitin C (685 aa)
        score_image   score_image   0.897
PTOV1
prostate tumor overexpressed 1; May activate transcription. Required for nuclear translocation of FLOT1. Promotes cell proliferation (416 aa)
            score_image   0.860
EGFR
epidermal growth factor receptor (1210 aa)
            score_image   0.834
SORBS1
sorbin and SH3 domain containing 1 (1292 aa)
          score_image score_image   0.827
FRS2
fibroblast growth factor receptor substrate 2; Adapter protein that links activated FGR and NGF receptors to downstream signaling pathways. Plays an important role in the activation of MAP kinases and in the phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3- kinase, in response to ligand-mediated activation of FGFR1. Modulates signaling via SHC1 by competing for a common binding site on NTRK1 (508 aa)
            score_image   0.826
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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