node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ALPI | GOT1 | ENSP00000295463 | ENSP00000359539 | alkaline phosphatase, intestinal | glutamic-oxaloacetic transaminase 1, soluble (aspartate aminotransferase 1); Biosynthesis of L-glutamate from L-aspartate or L- cysteine. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is conve [...] | 0.814 |
ALPI | GOT2 | ENSP00000295463 | ENSP00000245206 | alkaline phosphatase, intestinal | glutamic-oxaloacetic transaminase 2, mitochondrial (aspartate aminotransferase 2); Catalyzes the irreversible transamination of the L- tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Plays a key role in amino acid metabolism. Important for metabolite exchange between mitochondria and cytosol. Facilitates cellular uptake of long-chain free fatty acids | 0.811 |
ALPI | GPT | ENSP00000295463 | ENSP00000378408 | alkaline phosphatase, intestinal | glutamic-pyruvate transaminase (alanine aminotransferase); Catalyzes the reversible transamination between alanine and 2-oxoglutarate to form pyruvate and glutamate. Participates in cellular nitrogen metabolism and also in liver gluconeogenesis starting with precursors transported from skeletal muscles (By similarity) | 0.735 |
ALPI | LDHA | ENSP00000295463 | ENSP00000445175 | alkaline phosphatase, intestinal | lactate dehydrogenase A | 0.658 |
ALPI | LDHB | ENSP00000295463 | ENSP00000229319 | alkaline phosphatase, intestinal | lactate dehydrogenase B | 0.707 |
ALPI | LDHC | ENSP00000295463 | ENSP00000280704 | alkaline phosphatase, intestinal | lactate dehydrogenase C; Possible role in sperm motility | 0.720 |
ALPL | GOT1 | ENSP00000363965 | ENSP00000359539 | alkaline phosphatase, liver/bone/kidney | glutamic-oxaloacetic transaminase 1, soluble (aspartate aminotransferase 1); Biosynthesis of L-glutamate from L-aspartate or L- cysteine. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is conve [...] | 0.810 |
ALPL | GOT2 | ENSP00000363965 | ENSP00000245206 | alkaline phosphatase, liver/bone/kidney | glutamic-oxaloacetic transaminase 2, mitochondrial (aspartate aminotransferase 2); Catalyzes the irreversible transamination of the L- tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Plays a key role in amino acid metabolism. Important for metabolite exchange between mitochondria and cytosol. Facilitates cellular uptake of long-chain free fatty acids | 0.757 |
ALPL | GPT | ENSP00000363965 | ENSP00000378408 | alkaline phosphatase, liver/bone/kidney | glutamic-pyruvate transaminase (alanine aminotransferase); Catalyzes the reversible transamination between alanine and 2-oxoglutarate to form pyruvate and glutamate. Participates in cellular nitrogen metabolism and also in liver gluconeogenesis starting with precursors transported from skeletal muscles (By similarity) | 0.730 |
ALPL | LDHA | ENSP00000363965 | ENSP00000445175 | alkaline phosphatase, liver/bone/kidney | lactate dehydrogenase A | 0.636 |
ALPL | LDHB | ENSP00000363965 | ENSP00000229319 | alkaline phosphatase, liver/bone/kidney | lactate dehydrogenase B | 0.700 |
ALPL | LDHC | ENSP00000363965 | ENSP00000280704 | alkaline phosphatase, liver/bone/kidney | lactate dehydrogenase C; Possible role in sperm motility | 0.700 |
ALPP | GOT1 | ENSP00000375881 | ENSP00000359539 | alkaline phosphatase, placental | glutamic-oxaloacetic transaminase 1, soluble (aspartate aminotransferase 1); Biosynthesis of L-glutamate from L-aspartate or L- cysteine. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is conve [...] | 0.810 |
ALPP | GOT2 | ENSP00000375881 | ENSP00000245206 | alkaline phosphatase, placental | glutamic-oxaloacetic transaminase 2, mitochondrial (aspartate aminotransferase 2); Catalyzes the irreversible transamination of the L- tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Plays a key role in amino acid metabolism. Important for metabolite exchange between mitochondria and cytosol. Facilitates cellular uptake of long-chain free fatty acids | 0.757 |
ALPP | GPT | ENSP00000375881 | ENSP00000378408 | alkaline phosphatase, placental | glutamic-pyruvate transaminase (alanine aminotransferase); Catalyzes the reversible transamination between alanine and 2-oxoglutarate to form pyruvate and glutamate. Participates in cellular nitrogen metabolism and also in liver gluconeogenesis starting with precursors transported from skeletal muscles (By similarity) | 0.730 |
ALPP | LDHA | ENSP00000375881 | ENSP00000445175 | alkaline phosphatase, placental | lactate dehydrogenase A | 0.635 |
ALPP | LDHB | ENSP00000375881 | ENSP00000229319 | alkaline phosphatase, placental | lactate dehydrogenase B | 0.700 |
ALPP | LDHC | ENSP00000375881 | ENSP00000280704 | alkaline phosphatase, placental | lactate dehydrogenase C; Possible role in sperm motility | 0.700 |
GOT1 | ALPI | ENSP00000359539 | ENSP00000295463 | glutamic-oxaloacetic transaminase 1, soluble (aspartate aminotransferase 1); Biosynthesis of L-glutamate from L-aspartate or L- cysteine. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is conve [...] | alkaline phosphatase, intestinal | 0.814 |
GOT1 | ALPL | ENSP00000359539 | ENSP00000363965 | glutamic-oxaloacetic transaminase 1, soluble (aspartate aminotransferase 1); Biosynthesis of L-glutamate from L-aspartate or L- cysteine. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is conve [...] | alkaline phosphatase, liver/bone/kidney | 0.810 |