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STRINGSTRING
HP HP ING1 ING1 ALPP ALPP GPT GPT LDHA LDHA GOT1 GOT1 LDHC LDHC GOT2 GOT2 LDHB LDHB ALPI ALPI ALPL ALPL
"GPT" - glutamic-pyruvate transaminase (alanine aminotransferase) in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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protein of unknown 3D structure
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second shell of interactors
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experimentally determined
Predicted Interactions
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textmining
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protein homology
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GPTglutamic-pyruvate transaminase (alanine aminotransferase); Catalyzes the reversible transamination between alanine and 2-oxoglutarate to form pyruvate and glutamate. Participates in cellular nitrogen metabolism and also in liver gluconeogenesis starting with precursors transported from skeletal muscles (By similarity) (496 aa)    
Predicted Functional Partners:
GOT1
glutamic-oxaloacetic transaminase 1, soluble (aspartate aminotransferase 1); Biosynthesis of L-glutamate from L-aspartate or L- cysteine. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is conve [...] (413 aa)
      score_image     score_image   0.933
GOT2
glutamic-oxaloacetic transaminase 2, mitochondrial (aspartate aminotransferase 2); Catalyzes the irreversible transamination of the L- tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Plays a key role in amino acid metabolism. Important for metabolite exchange between mitochondria and cytosol. Facilitates cellular uptake of long-chain free fatty acids (430 aa)
      score_image     score_image   0.915
LDHC
lactate dehydrogenase C; Possible role in sperm motility (332 aa)
            score_image   0.764
LDHB
lactate dehydrogenase B (334 aa)
            score_image   0.753
HP
haptoglobin; As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage. Haptoglobin also acts as an Antimicrobial; Antioxidant, has antibacterial activity and plays a role in modulating many aspects of the acute phase response. Hemoglobin/haptoglobin complexes are rapidely cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation [...] (406 aa)
            score_image   0.748
ALPI
alkaline phosphatase, intestinal (528 aa)
            score_image   0.735
ALPP
alkaline phosphatase, placental (535 aa)
            score_image   0.730
ALPL
alkaline phosphatase, liver/bone/kidney (524 aa)
            score_image   0.730
LDHA
lactate dehydrogenase A (361 aa)
            score_image   0.713
ING1
inhibitor of growth family, member 1 (422 aa)
            score_image   0.659
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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