node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACRV1 | LIPN | ENSP00000432816 | ENSP00000383923 | acrosomal vesicle protein 1 | lipase, family member N; Plays a highly specific role in the last step of keratinocyte differentiation. May have an essential function in lipid metabolism of the most differentiated epidermal layers | 0.705 |
ACRV1 | SP9 | ENSP00000432816 | ENSP00000378418 | acrosomal vesicle protein 1 | Sp9 transcription factor homolog (mouse); Transcription factor which plays a key role in limb development. Positively regulates FGF8 expression in the apical ectodermal ridge (AER) and contributes to limb outgrowth in embryos (By similarity) | 0.871 |
FGF8 | GSX2 | ENSP00000321797 | ENSP00000319118 | fibroblast growth factor 8 (androgen-induced); Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. Required for normal brain, eye, ear and limb development during embryogenesis. Required for normal development of the gonadotropin-releasing hormone (GnRH) neuronal system | GS homeobox 2; Probable transcription factor that binds to the DNA sequence 5’-CNAATTAG-3’ (By similarity) | 0.442 |
FGF8 | SP9 | ENSP00000321797 | ENSP00000378418 | fibroblast growth factor 8 (androgen-induced); Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. Required for normal brain, eye, ear and limb development during embryogenesis. Required for normal development of the gonadotropin-releasing hormone (GnRH) neuronal system | Sp9 transcription factor homolog (mouse); Transcription factor which plays a key role in limb development. Positively regulates FGF8 expression in the apical ectodermal ridge (AER) and contributes to limb outgrowth in embryos (By similarity) | 0.649 |
GSX2 | FGF8 | ENSP00000319118 | ENSP00000321797 | GS homeobox 2; Probable transcription factor that binds to the DNA sequence 5’-CNAATTAG-3’ (By similarity) | fibroblast growth factor 8 (androgen-induced); Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. Required for normal brain, eye, ear and limb development during embryogenesis. Required for normal development of the gonadotropin-releasing hormone (GnRH) neuronal system | 0.442 |
GSX2 | SP9 | ENSP00000319118 | ENSP00000378418 | GS homeobox 2; Probable transcription factor that binds to the DNA sequence 5’-CNAATTAG-3’ (By similarity) | Sp9 transcription factor homolog (mouse); Transcription factor which plays a key role in limb development. Positively regulates FGF8 expression in the apical ectodermal ridge (AER) and contributes to limb outgrowth in embryos (By similarity) | 0.648 |
LIPN | ACRV1 | ENSP00000383923 | ENSP00000432816 | lipase, family member N; Plays a highly specific role in the last step of keratinocyte differentiation. May have an essential function in lipid metabolism of the most differentiated epidermal layers | acrosomal vesicle protein 1 | 0.705 |
LIPN | PCSK5 | ENSP00000383923 | ENSP00000446280 | lipase, family member N; Plays a highly specific role in the last step of keratinocyte differentiation. May have an essential function in lipid metabolism of the most differentiated epidermal layers | proprotein convertase subtilisin/kexin type 5; Likely to represent a widespread endoprotease activity within the constitutive and regulated secretory pathway. Capable of cleavage at the RX(K/R)R consensus motif. Plays an essential role in pregnancy establishment by proteolytic activation of a number of important factors such as BMP2, CALD1 and alpha- integrins | 0.830 |
LIPN | SP9 | ENSP00000383923 | ENSP00000378418 | lipase, family member N; Plays a highly specific role in the last step of keratinocyte differentiation. May have an essential function in lipid metabolism of the most differentiated epidermal layers | Sp9 transcription factor homolog (mouse); Transcription factor which plays a key role in limb development. Positively regulates FGF8 expression in the apical ectodermal ridge (AER) and contributes to limb outgrowth in embryos (By similarity) | 0.810 |
MINA | SP9 | ENSP00000328251 | ENSP00000378418 | MYC induced nuclear antigen | Sp9 transcription factor homolog (mouse); Transcription factor which plays a key role in limb development. Positively regulates FGF8 expression in the apical ectodermal ridge (AER) and contributes to limb outgrowth in embryos (By similarity) | 0.624 |
P2RX7 | SP9 | ENSP00000442349 | ENSP00000378418 | purinergic receptor P2X, ligand-gated ion channel, 7; Receptor for ATP that acts as a ligand-gated ion channel. Responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Could function in both fast synaptic transmission and the ATP-mediated lysis of antigen-presenting cells | Sp9 transcription factor homolog (mouse); Transcription factor which plays a key role in limb development. Positively regulates FGF8 expression in the apical ectodermal ridge (AER) and contributes to limb outgrowth in embryos (By similarity) | 0.614 |
PCSK5 | LIPN | ENSP00000446280 | ENSP00000383923 | proprotein convertase subtilisin/kexin type 5; Likely to represent a widespread endoprotease activity within the constitutive and regulated secretory pathway. Capable of cleavage at the RX(K/R)R consensus motif. Plays an essential role in pregnancy establishment by proteolytic activation of a number of important factors such as BMP2, CALD1 and alpha- integrins | lipase, family member N; Plays a highly specific role in the last step of keratinocyte differentiation. May have an essential function in lipid metabolism of the most differentiated epidermal layers | 0.830 |
PCSK5 | SP9 | ENSP00000446280 | ENSP00000378418 | proprotein convertase subtilisin/kexin type 5; Likely to represent a widespread endoprotease activity within the constitutive and regulated secretory pathway. Capable of cleavage at the RX(K/R)R consensus motif. Plays an essential role in pregnancy establishment by proteolytic activation of a number of important factors such as BMP2, CALD1 and alpha- integrins | Sp9 transcription factor homolog (mouse); Transcription factor which plays a key role in limb development. Positively regulates FGF8 expression in the apical ectodermal ridge (AER) and contributes to limb outgrowth in embryos (By similarity) | 0.589 |
RAPGEF4 | SP9 | ENSP00000380271 | ENSP00000378418 | Rap guanine nucleotide exchange factor (GEF) 4; Guanine nucleotide exchange factor (GEF) for RAP1A, RAP1B and RAP2A small GTPases that is activated by binding cAMP. Seems not to activate RAB3A. Involved in cAMP-dependent, PKA- independent exocytosis through interaction with RIMS2 (By similarity) | Sp9 transcription factor homolog (mouse); Transcription factor which plays a key role in limb development. Positively regulates FGF8 expression in the apical ectodermal ridge (AER) and contributes to limb outgrowth in embryos (By similarity) | 0.567 |
RUNX1 | SP9 | ENSP00000300305 | ENSP00000378418 | runt-related transcription factor 1 | Sp9 transcription factor homolog (mouse); Transcription factor which plays a key role in limb development. Positively regulates FGF8 expression in the apical ectodermal ridge (AER) and contributes to limb outgrowth in embryos (By similarity) | 0.698 |
RUNX1 | TNF | ENSP00000300305 | ENSP00000398698 | runt-related transcription factor 1 | tumor necrosis factor | 0.688 |
SP9 | ACRV1 | ENSP00000378418 | ENSP00000432816 | Sp9 transcription factor homolog (mouse); Transcription factor which plays a key role in limb development. Positively regulates FGF8 expression in the apical ectodermal ridge (AER) and contributes to limb outgrowth in embryos (By similarity) | acrosomal vesicle protein 1 | 0.871 |
SP9 | FGF8 | ENSP00000378418 | ENSP00000321797 | Sp9 transcription factor homolog (mouse); Transcription factor which plays a key role in limb development. Positively regulates FGF8 expression in the apical ectodermal ridge (AER) and contributes to limb outgrowth in embryos (By similarity) | fibroblast growth factor 8 (androgen-induced); Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. Required for normal brain, eye, ear and limb development during embryogenesis. Required for normal development of the gonadotropin-releasing hormone (GnRH) neuronal system | 0.649 |
SP9 | GSX2 | ENSP00000378418 | ENSP00000319118 | Sp9 transcription factor homolog (mouse); Transcription factor which plays a key role in limb development. Positively regulates FGF8 expression in the apical ectodermal ridge (AER) and contributes to limb outgrowth in embryos (By similarity) | GS homeobox 2; Probable transcription factor that binds to the DNA sequence 5’-CNAATTAG-3’ (By similarity) | 0.648 |
SP9 | LIPN | ENSP00000378418 | ENSP00000383923 | Sp9 transcription factor homolog (mouse); Transcription factor which plays a key role in limb development. Positively regulates FGF8 expression in the apical ectodermal ridge (AER) and contributes to limb outgrowth in embryos (By similarity) | lipase, family member N; Plays a highly specific role in the last step of keratinocyte differentiation. May have an essential function in lipid metabolism of the most differentiated epidermal layers | 0.810 |