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STRINGSTRING
PCSK5 PCSK5 P2RX7 P2RX7 LIPN LIPN ACRV1 ACRV1 TNF TNF SP9 SP9 RUNX1 RUNX1 FGF8 FGF8 GSX2 GSX2 MINA MINA RAPGEF4 RAPGEF4
"SP9" - Sp9 transcription factor homolog in Homo sapiens
Nodes:
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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small nodes:
protein of unknown 3D structure
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some 3D structure is known or predicted
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query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
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Known Interactions
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from curated databases
experiment edge
experimentally determined
Predicted Interactions
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gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
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textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
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[Homology]
Score
SP9Sp9 transcription factor homolog (mouse); Transcription factor which plays a key role in limb development. Positively regulates FGF8 expression in the apical ectodermal ridge (AER) and contributes to limb outgrowth in embryos (By similarity) (484 aa)    
Predicted Functional Partners:
ACRV1
acrosomal vesicle protein 1 (265 aa)
            score_image   0.871
LIPN
lipase, family member N; Plays a highly specific role in the last step of keratinocyte differentiation. May have an essential function in lipid metabolism of the most differentiated epidermal layers (398 aa)
            score_image   0.810
RUNX1
runt-related transcription factor 1 (480 aa)
            score_image   0.698
FGF8
fibroblast growth factor 8 (androgen-induced); Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. Required for normal brain, eye, ear and limb development during embryogenesis. Required for normal development of the gonadotropin-releasing hormone (GnRH) neuronal system (244 aa)
            score_image   0.649
GSX2
GS homeobox 2; Probable transcription factor that binds to the DNA sequence 5’-CNAATTAG-3’ (By similarity) (304 aa)
            score_image   0.648
MINA
MYC induced nuclear antigen (465 aa)
        score_image   score_image   0.624
TNF
tumor necrosis factor (233 aa)
            score_image   0.615
P2RX7
purinergic receptor P2X, ligand-gated ion channel, 7; Receptor for ATP that acts as a ligand-gated ion channel. Responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Could function in both fast synaptic transmission and the ATP-mediated lysis of antigen-presenting cells (595 aa)
            score_image   0.614
PCSK5
proprotein convertase subtilisin/kexin type 5; Likely to represent a widespread endoprotease activity within the constitutive and regulated secretory pathway. Capable of cleavage at the RX(K/R)R consensus motif. Plays an essential role in pregnancy establishment by proteolytic activation of a number of important factors such as BMP2, CALD1 and alpha- integrins (1860 aa)
      score_image score_image   score_image   0.589
RAPGEF4
Rap guanine nucleotide exchange factor (GEF) 4; Guanine nucleotide exchange factor (GEF) for RAP1A, RAP1B and RAP2A small GTPases that is activated by binding cAMP. Seems not to activate RAB3A. Involved in cAMP-dependent, PKA- independent exocytosis through interaction with RIMS2 (By similarity) (1011 aa)
            score_image   0.567
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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