Full Link:
  • Version:
  • 10.0 (archived version)
STRINGSTRING
DAG1 DAG1 UTRN UTRN PRX PRX DTNA DTNA DRP2 DRP2 DSCR3 DSCR3 DPYSL2 DPYSL2 BTK BTK
"DRP2" - dystrophin related protein 2 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
DRP2dystrophin related protein 2; Possibly involved in membrane-cytoskeleton interactions of the central nervous system (957 aa)    
Predicted Functional Partners:
PRX
periaxin; Seems to be required for maintenance of peripheral nerve myelin sheath. May have a role in axon-glial interactions, possibly by interacting with the cytoplasmic domains of integral membrane proteins such as myelin-associated glycoprotein in the periaxonal regions of the Schwann cell plasma membrane. May have a role in the early phases of myelin deposition (1461 aa)
        score_image   score_image   0.782
DAG1
dystroglycan 1 (dystrophin-associated glycoprotein 1); The dystroglycan complex is involved in a number of processes including laminin and basement membrane assembly, sarcolemmal stability, cell survival, peripheral nerve myelination, nodal structure, cell migration, and epithelial polarization (895 aa)
        score_image   score_image   0.648
DTNA
dystrobrevin, alpha (743 aa)
        score_image   score_image score_image 0.628
BTK
Bruton agammaglobulinemia tyrosine kinase; Non-receptor tyrosine kinase indispensable for B lymphocyte development, differentiation and signaling. Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activation. After BCR engagement and activation at the plasma membrane, phosphorylates PLCG2 at several sites, igniting the downstream signaling pathway through calcium mobilization, followed by activation of the protein kinase C (PKC) family members. PLCG2 phosphorylation is performed in close cooperation with the adapter protein B-cel [...] (659 aa)
            score_image   0.609
DPYSL2
dihydropyrimidinase-like 2; Plays a role in neuronal development and polarity, as well as in axon growth and guidance, neuronal growth cone collapse and cell migration. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton (By similarity). Plays a role in neuron projection morphogenesis (572 aa)
        score_image       0.603
UTRN
utrophin; May play a role in anchoring the cytoskeleton to the plasma membrane (By similarity) (3433 aa)
        score_image   score_image score_image 0.583
DSCR3
Down syndrome critical region gene 3 (297 aa)
            score_image   0.557
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Server load: low (29%)