node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BTK | DRP2 | ENSP00000308176 | ENSP00000378635 | Bruton agammaglobulinemia tyrosine kinase; Non-receptor tyrosine kinase indispensable for B lymphocyte development, differentiation and signaling. Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activation. After BCR engagement and activation at the plasma membrane, phosphorylates PLCG2 at several sites, igniting the downstream signaling pathway through calcium mobilization, followed by activation of the protein kinase C (PKC) family members. PLCG2 phosphorylation is performed in close cooperation with the adapter protein B-cel [...] | dystrophin related protein 2; Possibly involved in membrane-cytoskeleton interactions of the central nervous system | 0.609 |
DAG1 | DRP2 | ENSP00000312435 | ENSP00000378635 | dystroglycan 1 (dystrophin-associated glycoprotein 1); The dystroglycan complex is involved in a number of processes including laminin and basement membrane assembly, sarcolemmal stability, cell survival, peripheral nerve myelination, nodal structure, cell migration, and epithelial polarization | dystrophin related protein 2; Possibly involved in membrane-cytoskeleton interactions of the central nervous system | 0.648 |
DAG1 | PRX | ENSP00000312435 | ENSP00000326018 | dystroglycan 1 (dystrophin-associated glycoprotein 1); The dystroglycan complex is involved in a number of processes including laminin and basement membrane assembly, sarcolemmal stability, cell survival, peripheral nerve myelination, nodal structure, cell migration, and epithelial polarization | periaxin; Seems to be required for maintenance of peripheral nerve myelin sheath. May have a role in axon-glial interactions, possibly by interacting with the cytoplasmic domains of integral membrane proteins such as myelin-associated glycoprotein in the periaxonal regions of the Schwann cell plasma membrane. May have a role in the early phases of myelin deposition | 0.614 |
DAG1 | UTRN | ENSP00000312435 | ENSP00000356515 | dystroglycan 1 (dystrophin-associated glycoprotein 1); The dystroglycan complex is involved in a number of processes including laminin and basement membrane assembly, sarcolemmal stability, cell survival, peripheral nerve myelination, nodal structure, cell migration, and epithelial polarization | utrophin; May play a role in anchoring the cytoskeleton to the plasma membrane (By similarity) | 0.999 |
DPYSL2 | DRP2 | ENSP00000309539 | ENSP00000378635 | dihydropyrimidinase-like 2; Plays a role in neuronal development and polarity, as well as in axon growth and guidance, neuronal growth cone collapse and cell migration. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton (By similarity). Plays a role in neuron projection morphogenesis | dystrophin related protein 2; Possibly involved in membrane-cytoskeleton interactions of the central nervous system | 0.603 |
DRP2 | BTK | ENSP00000378635 | ENSP00000308176 | dystrophin related protein 2; Possibly involved in membrane-cytoskeleton interactions of the central nervous system | Bruton agammaglobulinemia tyrosine kinase; Non-receptor tyrosine kinase indispensable for B lymphocyte development, differentiation and signaling. Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activation. After BCR engagement and activation at the plasma membrane, phosphorylates PLCG2 at several sites, igniting the downstream signaling pathway through calcium mobilization, followed by activation of the protein kinase C (PKC) family members. PLCG2 phosphorylation is performed in close cooperation with the adapter protein B-cel [...] | 0.609 |
DRP2 | DAG1 | ENSP00000378635 | ENSP00000312435 | dystrophin related protein 2; Possibly involved in membrane-cytoskeleton interactions of the central nervous system | dystroglycan 1 (dystrophin-associated glycoprotein 1); The dystroglycan complex is involved in a number of processes including laminin and basement membrane assembly, sarcolemmal stability, cell survival, peripheral nerve myelination, nodal structure, cell migration, and epithelial polarization | 0.648 |
DRP2 | DPYSL2 | ENSP00000378635 | ENSP00000309539 | dystrophin related protein 2; Possibly involved in membrane-cytoskeleton interactions of the central nervous system | dihydropyrimidinase-like 2; Plays a role in neuronal development and polarity, as well as in axon growth and guidance, neuronal growth cone collapse and cell migration. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton (By similarity). Plays a role in neuron projection morphogenesis | 0.603 |
DRP2 | DSCR3 | ENSP00000378635 | ENSP00000311399 | dystrophin related protein 2; Possibly involved in membrane-cytoskeleton interactions of the central nervous system | Down syndrome critical region gene 3 | 0.557 |
DRP2 | DTNA | ENSP00000378635 | ENSP00000382064 | dystrophin related protein 2; Possibly involved in membrane-cytoskeleton interactions of the central nervous system | dystrobrevin, alpha | 0.628 |
DRP2 | PRX | ENSP00000378635 | ENSP00000326018 | dystrophin related protein 2; Possibly involved in membrane-cytoskeleton interactions of the central nervous system | periaxin; Seems to be required for maintenance of peripheral nerve myelin sheath. May have a role in axon-glial interactions, possibly by interacting with the cytoplasmic domains of integral membrane proteins such as myelin-associated glycoprotein in the periaxonal regions of the Schwann cell plasma membrane. May have a role in the early phases of myelin deposition | 0.782 |
DRP2 | UTRN | ENSP00000378635 | ENSP00000356515 | dystrophin related protein 2; Possibly involved in membrane-cytoskeleton interactions of the central nervous system | utrophin; May play a role in anchoring the cytoskeleton to the plasma membrane (By similarity) | 0.583 |
DSCR3 | DRP2 | ENSP00000311399 | ENSP00000378635 | Down syndrome critical region gene 3 | dystrophin related protein 2; Possibly involved in membrane-cytoskeleton interactions of the central nervous system | 0.557 |
DTNA | DRP2 | ENSP00000382064 | ENSP00000378635 | dystrobrevin, alpha | dystrophin related protein 2; Possibly involved in membrane-cytoskeleton interactions of the central nervous system | 0.628 |
DTNA | UTRN | ENSP00000382064 | ENSP00000356515 | dystrobrevin, alpha | utrophin; May play a role in anchoring the cytoskeleton to the plasma membrane (By similarity) | 0.946 |
PRX | DAG1 | ENSP00000326018 | ENSP00000312435 | periaxin; Seems to be required for maintenance of peripheral nerve myelin sheath. May have a role in axon-glial interactions, possibly by interacting with the cytoplasmic domains of integral membrane proteins such as myelin-associated glycoprotein in the periaxonal regions of the Schwann cell plasma membrane. May have a role in the early phases of myelin deposition | dystroglycan 1 (dystrophin-associated glycoprotein 1); The dystroglycan complex is involved in a number of processes including laminin and basement membrane assembly, sarcolemmal stability, cell survival, peripheral nerve myelination, nodal structure, cell migration, and epithelial polarization | 0.614 |
PRX | DRP2 | ENSP00000326018 | ENSP00000378635 | periaxin; Seems to be required for maintenance of peripheral nerve myelin sheath. May have a role in axon-glial interactions, possibly by interacting with the cytoplasmic domains of integral membrane proteins such as myelin-associated glycoprotein in the periaxonal regions of the Schwann cell plasma membrane. May have a role in the early phases of myelin deposition | dystrophin related protein 2; Possibly involved in membrane-cytoskeleton interactions of the central nervous system | 0.782 |
UTRN | DAG1 | ENSP00000356515 | ENSP00000312435 | utrophin; May play a role in anchoring the cytoskeleton to the plasma membrane (By similarity) | dystroglycan 1 (dystrophin-associated glycoprotein 1); The dystroglycan complex is involved in a number of processes including laminin and basement membrane assembly, sarcolemmal stability, cell survival, peripheral nerve myelination, nodal structure, cell migration, and epithelial polarization | 0.999 |
UTRN | DRP2 | ENSP00000356515 | ENSP00000378635 | utrophin; May play a role in anchoring the cytoskeleton to the plasma membrane (By similarity) | dystrophin related protein 2; Possibly involved in membrane-cytoskeleton interactions of the central nervous system | 0.583 |
UTRN | DTNA | ENSP00000356515 | ENSP00000382064 | utrophin; May play a role in anchoring the cytoskeleton to the plasma membrane (By similarity) | dystrobrevin, alpha | 0.946 |