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STRINGSTRING
PRPF40B PRPF40B MS4A1 MS4A1 CD63 CD63 HLA-DRA HLA-DRA UBC UBC HLA-DRB5 HLA-DRB5 MARCH1 MARCH1 MBP MBP CD74 CD74 HLA-DRB1 HLA-DRB1 HLA-DMA HLA-DMA
"HLA-DRA" - major histocompatibility complex, class II, DR alpha in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
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Textmining
[Homology]
Score
HLA-DRAmajor histocompatibility complex, class II, DR alpha (254 aa)    
Predicted Functional Partners:
MS4A1
membrane-spanning 4-domains, subfamily A, member 1; This protein may be involved in the regulation of B-cell activation and proliferation (297 aa)
        score_image       0.778
CD74
CD74 molecule, major histocompatibility complex, class II invariant chain (296 aa)
      score_image score_image       0.744
HLA-DRB5
major histocompatibility complex, class II, DR beta 5 (266 aa)
      score_image score_image   score_image score_image 0.711
HLA-DRB1
major histocompatibility complex, class II, DR beta 1 (266 aa)
      score_image score_image   score_image score_image 0.705
UBC
ubiquitin C (685 aa)
        score_image       0.683
HLA-DMA
major histocompatibility complex, class II, DM alpha (261 aa)
      score_image score_image   score_image score_image 0.671
MBP
myelin basic protein (197 aa)
        score_image   score_image   0.587
MARCH1
membrane-associated ring finger (C3HC4) 1, E3 ubiquitin protein ligase; E3 ubiquitin-protein ligase that mediates ubiquitination of TFRC, CD86, FAS and MHC class II proteins, such as HLA-DR alpha and beta, and promotes their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. By constitutively ubiquitinating MHC class II proteins in immature dendritic cells, down-regulates their cell surface localization thus sequestering them in the intracellular endosomal system (289 aa)
        score_image       0.576
PRPF40B
PRP40 pre-mRNA processing factor 40 homolog B (S. cerevisiae); May be involved in pre-mRNA splicing (871 aa)
        score_image       0.574
CD63
CD63 molecule; This antigen is associated with early stages of melanoma tumor progression. May play a role in growth regulation (238 aa)
        score_image       0.570
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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