Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes:
protein of unknown 3D structure
protein of unknown 3D structure
large nodes:
some 3D structure is known or predicted
some 3D structure is known or predicted
Node Color
colored nodes:
query proteins and first shell of interactors
query proteins and first shell of interactors
white nodes:
second shell of interactors
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Your Input:
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Neighborhood |
Gene Fusion |
Cooccurence |
Coexpression |
Experiments |
Databases |
Textmining |
[Homology] |
Score |
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 | DHRS7B | dehydrogenase/reductase (SDR family) member 7B; Putative oxidoreductase (Potential) (325 aa) | ||||||||||||
Predicted Functional Partners:
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 | BRE | brain and reproductive organ-expressed (TNFRSF1A modulator) (415 aa) |
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0.740 | ||||||||||
 | ACIN1 | apoptotic chromatin condensation inducer 1; Component of a splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of a few core proteins and several more peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Induces apoptotic chromatin condensation after activation by CASP3. Regulates cyclin A1, but not cyclin A2, expression in leukemia cells (1341 aa) |
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0.644 | ||||||||||
 | UBC | ubiquitin C (685 aa) |
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0.644 | ||||||||||
 | ACACA | acetyl-CoA carboxylase alpha (2383 aa) |
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0.581 | |||||||||
 | ACACB | acetyl-CoA carboxylase beta; ACC-beta may be involved in the provision of malonyl-CoA or in the regulation of fatty acid oxidation, rather than fatty acid biosynthesis. Carries out three functions- biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase (2458 aa) |
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0.581 | |||||||||
 | TMEM98 | transmembrane protein 98 (226 aa) |
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0.579 | ||||||||||
 | LRRC48 | leucine rich repeat containing 48 (523 aa) |
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0.575 | ||||||||||
 | SMCR8 | Smith-Magenis syndrome chromosome region, candidate 8 (937 aa) |
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0.514 | ||||||||||
 | TBC1D29 | TBC1 domain family, member 29 (150 aa) |
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0.514 | ||||||||||
 | C17orf103 | chromosome 17 open reading frame 103 (112 aa) |
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0.509 | ||||||||||
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Other names: H. sapiens, Homo, Homo sapiens, human, man
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