splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes: protein of unknown 3D structure
large nodes: some 3D structure is known or predicted
Node Color
colored nodes: query proteins and first shell of interactors
white nodes: second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SLC5A10
solute carrier family 5 (sodium/glucose cotransporter), member 10; High capacity transporter for mannose and fructose and, to a lesser extent, glucose, AMG, and galactose (612 aa)
Predicted Functional Partners:
KIAA1919
KIAA1919; May function as a sodium-dependent glucose transporter (By similarity) (518 aa)
0.457
FAM83G
family with sequence similarity 83, member G (823 aa)
0.408
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606 Other names: H. sapiens, Homo, Homo sapiens, human, man
a tab-delimited file describing the names, domains and annotated functions of the network proteins
Browse interactions in tabular form:
node1
node2
node1 accession
node2 accession
node1 annotation
node2 annotation
score
FAM83G
SLC5A10
ENSP00000343279
ENSP00000379008
family with sequence similarity 83, member G
solute carrier family 5 (sodium/glucose cotransporter), member 10; High capacity transporter for mannose and fructose and, to a lesser extent, glucose, AMG, and galactose
0.408
KIAA1919
SLC5A10
ENSP00000357840
ENSP00000379008
KIAA1919; May function as a sodium-dependent glucose transporter (By similarity)
solute carrier family 5 (sodium/glucose cotransporter), member 10; High capacity transporter for mannose and fructose and, to a lesser extent, glucose, AMG, and galactose
0.457
SLC5A10
FAM83G
ENSP00000379008
ENSP00000343279
solute carrier family 5 (sodium/glucose cotransporter), member 10; High capacity transporter for mannose and fructose and, to a lesser extent, glucose, AMG, and galactose
family with sequence similarity 83, member G
0.408
SLC5A10
KIAA1919
ENSP00000379008
ENSP00000357840
solute carrier family 5 (sodium/glucose cotransporter), member 10; High capacity transporter for mannose and fructose and, to a lesser extent, glucose, AMG, and galactose
KIAA1919; May function as a sodium-dependent glucose transporter (By similarity)
Co-purification, co-crystallization, Yeast2Hybrid, Genetic Interactions, etc ... as imported from primary sources.
Neighborhood
Groups of genes that are frequently observed in each other's genomic neighborhood.
Databases
Known metabolic pathways, protein complexes, signal transduction pathways, etc ... from curated databases.
Fusion
Genes that are sometimes fused into single open reading frames.
Coexpression
Proteins whose genes are observed to be correlated in expression, across a large number of experiments.
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Network Stats
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Functional enrichments in your networkNote: some enrichments may be expected here (why?)
Enrichment analysis is still ongoing, please wait ...
Statistical background
For the above enrichment analysis, the following statistical background is assumed: