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STRINGSTRING
LOC284912 LOC284912 FAM83F FAM83F C22orf29 C22orf29 KLHDC7B KLHDC7B LOC642778 LOC642778 KLHDC10 KLHDC10 BIRC6 BIRC6
"KLHDC7B" - kelch domain containing 7B in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
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Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
KLHDC7Bkelch domain containing 7B (594 aa)    
Predicted Functional Partners:
LOC642778
NPIP-like protein 1 (369 aa)
      score_image     score_image   0.603
C22orf29
chromosome 22 open reading frame 29; Could induce apoptosis in a BH3 domain-dependent manner. The direct interaction network of Bcl-2 family members may play a key role in modulation BOP intrinsic apoptotic signaling activity (364 aa)
            score_image   0.585
FAM83F
family with sequence similarity 83, member F (500 aa)
            score_image   0.580
LOC284912
Hypothetical gene supported by BC001801 (80 aa)
            score_image   0.568
BIRC6
baculoviral IAP repeat containing 6; Anti-apoptotic protein which can regulate cell death by controlling caspases and by acting as an E3 ubiquitin-protein ligase. Has an unusual ubiquitin conjugation system in that it could combine in a single polypeptide, ubiquitin conjugating (E2) with ubiquitin ligase (E3) activity, forming a chimeric E2/E3 ubiquitin ligase. Its tragets include CASP9 and DIABLO/SMAC. Acts as an inhibitor of CASP3, CASP7 and CASP9. Important regulator for the final stages of cytokinesis. Crucial for normal vesicle targeting to the site of abscission, but also for the [...] (4857 aa)
        score_image   score_image   0.481
KLHDC10
kelch domain containing 10 (442 aa)
            score_image   0.429
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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