SMCR7 protein (Homo sapiens) - STRING network view

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SMCR7

Smith-Magenis syndrome chromosome region, candidate 7; Mitochondrial outer membrane protein which regulates mitochondrial morphology. Mitochondrial morphology is controlled by two opposites processes- fusion and fission. Can directly recruit the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface (465 aa)

Predicted Functional Partners:

DNM1L

0.872

MFF

0.658

UBC

0.620

TOMM20

0.576

FIS1

0.514

CEND1

0.480

RABAC1

0.465

TMEM168

0.459

SIRPG

0.416

MBOAT1

0.414

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CEND1	SMCR7	ENSP00000328336	ENSP00000379057	cell cycle exit and neuronal differentiation 1; Involved in neuroblastoma cell differentiation (By similarity)	Smith-Magenis syndrome chromosome region, candidate 7; Mitochondrial outer membrane protein which regulates mitochondrial morphology. Mitochondrial morphology is controlled by two opposites processes- fusion and fission. Can directly recruit the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface	0.480
DNM1L	FIS1	ENSP00000450399	ENSP00000223136	dynamin 1-like	fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae); Promotes the fragmentation of the mitochondrial network and its perinuclear clustering. Can induce cytochrome c release from the mitochondrion to the cytosol, ultimately leading to apoptosis. Also mediates peroxisomal fission	0.994
DNM1L	MFF	ENSP00000450399	ENSP00000302037	dynamin 1-like	mitochondrial fission factor; Plays a role in mitochondrial and peroxisomal fission	0.960
DNM1L	SMCR7	ENSP00000450399	ENSP00000379057	dynamin 1-like	Smith-Magenis syndrome chromosome region, candidate 7; Mitochondrial outer membrane protein which regulates mitochondrial morphology. Mitochondrial morphology is controlled by two opposites processes- fusion and fission. Can directly recruit the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface	0.872
DNM1L	TOMM20	ENSP00000450399	ENSP00000355566	dynamin 1-like	translocase of outer mitochondrial membrane 20 homolog (yeast); Central component of the receptor complex responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with TOM22 functions as the transit peptide receptor at the surface of the mitochondrion outer membrane and facilitates the movement of preproteins into the TOM40 translocation pore (By similarity)	0.601
DNM1L	UBC	ENSP00000450399	ENSP00000344818	dynamin 1-like	ubiquitin C	0.989
FIS1	DNM1L	ENSP00000223136	ENSP00000450399	fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae); Promotes the fragmentation of the mitochondrial network and its perinuclear clustering. Can induce cytochrome c release from the mitochondrion to the cytosol, ultimately leading to apoptosis. Also mediates peroxisomal fission	dynamin 1-like	0.994
FIS1	MFF	ENSP00000223136	ENSP00000302037	fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae); Promotes the fragmentation of the mitochondrial network and its perinuclear clustering. Can induce cytochrome c release from the mitochondrion to the cytosol, ultimately leading to apoptosis. Also mediates peroxisomal fission	mitochondrial fission factor; Plays a role in mitochondrial and peroxisomal fission	0.753
FIS1	SMCR7	ENSP00000223136	ENSP00000379057	fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae); Promotes the fragmentation of the mitochondrial network and its perinuclear clustering. Can induce cytochrome c release from the mitochondrion to the cytosol, ultimately leading to apoptosis. Also mediates peroxisomal fission	Smith-Magenis syndrome chromosome region, candidate 7; Mitochondrial outer membrane protein which regulates mitochondrial morphology. Mitochondrial morphology is controlled by two opposites processes- fusion and fission. Can directly recruit the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface	0.514
FIS1	TOMM20	ENSP00000223136	ENSP00000355566	fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae); Promotes the fragmentation of the mitochondrial network and its perinuclear clustering. Can induce cytochrome c release from the mitochondrion to the cytosol, ultimately leading to apoptosis. Also mediates peroxisomal fission	translocase of outer mitochondrial membrane 20 homolog (yeast); Central component of the receptor complex responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with TOM22 functions as the transit peptide receptor at the surface of the mitochondrion outer membrane and facilitates the movement of preproteins into the TOM40 translocation pore (By similarity)	0.797
FIS1	UBC	ENSP00000223136	ENSP00000344818	fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae); Promotes the fragmentation of the mitochondrial network and its perinuclear clustering. Can induce cytochrome c release from the mitochondrion to the cytosol, ultimately leading to apoptosis. Also mediates peroxisomal fission	ubiquitin C	0.898
MBOAT1	SMCR7	ENSP00000324944	ENSP00000379057	membrane bound O-acyltransferase domain containing 1; Acyltransferase which mediates the conversion of lysophosphatidylserine (1-acyl-2-hydroxy-sn-glycero-3-phospho-L- serine or LPS) into phosphatidylserine (1,2-diacyl-sn-glycero-3- phospho-L-serine or PS) (LPSAT activity). Prefers oleoyl-CoA as the acyl donor. Lysophospholipid acyltransferases (LPLATs) catalyze the reacylation step of the phospholipid remodeling pathway also known as the Lands cycle	Smith-Magenis syndrome chromosome region, candidate 7; Mitochondrial outer membrane protein which regulates mitochondrial morphology. Mitochondrial morphology is controlled by two opposites processes- fusion and fission. Can directly recruit the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface	0.414
MFF	DNM1L	ENSP00000302037	ENSP00000450399	mitochondrial fission factor; Plays a role in mitochondrial and peroxisomal fission	dynamin 1-like	0.960
MFF	FIS1	ENSP00000302037	ENSP00000223136	mitochondrial fission factor; Plays a role in mitochondrial and peroxisomal fission	fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae); Promotes the fragmentation of the mitochondrial network and its perinuclear clustering. Can induce cytochrome c release from the mitochondrion to the cytosol, ultimately leading to apoptosis. Also mediates peroxisomal fission	0.753
MFF	SMCR7	ENSP00000302037	ENSP00000379057	mitochondrial fission factor; Plays a role in mitochondrial and peroxisomal fission	Smith-Magenis syndrome chromosome region, candidate 7; Mitochondrial outer membrane protein which regulates mitochondrial morphology. Mitochondrial morphology is controlled by two opposites processes- fusion and fission. Can directly recruit the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface	0.658
MFF	UBC	ENSP00000302037	ENSP00000344818	mitochondrial fission factor; Plays a role in mitochondrial and peroxisomal fission	ubiquitin C	0.620
RABAC1	SMCR7	ENSP00000222008	ENSP00000379057	Rab acceptor 1 (prenylated); General Rab protein regulator required for vesicle formation from the Golgi complex. May control vesicle docking and fusion by mediating the action of Rab GTPases to the SNARE complexes. In addition it inhibits the removal of Rab GTPases from the membrane by GDI (By similarity)	Smith-Magenis syndrome chromosome region, candidate 7; Mitochondrial outer membrane protein which regulates mitochondrial morphology. Mitochondrial morphology is controlled by two opposites processes- fusion and fission. Can directly recruit the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface	0.465
RABAC1	UBC	ENSP00000222008	ENSP00000344818	Rab acceptor 1 (prenylated); General Rab protein regulator required for vesicle formation from the Golgi complex. May control vesicle docking and fusion by mediating the action of Rab GTPases to the SNARE complexes. In addition it inhibits the removal of Rab GTPases from the membrane by GDI (By similarity)	ubiquitin C	0.963
SIRPG	SMCR7	ENSP00000305529	ENSP00000379057	signal-regulatory protein gamma; Probable immunoglobulin-like cell surface receptor. On binding with CD47, mediates cell-cell adhesion. Engagement on T- cells by CD47 on antigen-presenting cells results in enhanced antigen-specific T-cell proliferation and costimulates T-cell activation	Smith-Magenis syndrome chromosome region, candidate 7; Mitochondrial outer membrane protein which regulates mitochondrial morphology. Mitochondrial morphology is controlled by two opposites processes- fusion and fission. Can directly recruit the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface	0.416
SMCR7	CEND1	ENSP00000379057	ENSP00000328336	Smith-Magenis syndrome chromosome region, candidate 7; Mitochondrial outer membrane protein which regulates mitochondrial morphology. Mitochondrial morphology is controlled by two opposites processes- fusion and fission. Can directly recruit the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface	cell cycle exit and neuronal differentiation 1; Involved in neuroblastoma cell differentiation (By similarity)	0.480

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