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CXCR1 CXCR1 CXCL1 CXCL1 CXCR2 CXCR2 CCL20 CCL20 CXCR3 CXCR3 CXCL12 CXCL12 CCL5 CCL5 CCR5 CCR5 CXCL11 CXCL11 CXCL10 CXCL10 CCR1 CCR1
"CXCL1" - chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) in Homo sapiens
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Predicted Interactions
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Score
CXCL1chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha); Has chemotactic activity for neutrophils. May play a role in inflammation and exerts its effects on endothelial cells in an autocrine fashion. In vitro, the processed forms GRO- alpha(4-73), GRO-alpha(5-73) and GRO-alpha(6-73) show a 30-fold higher chemotactic activity (107 aa)    
Predicted Functional Partners:
CXCR2
chemokine (C-X-C motif) receptor 2; Receptor for interleukin-8 which is a powerful neutrophil chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Binds to IL-8 with high affinity. Also binds with high affinity to CXCL3, GRO/MGSA and NAP-2 (360 aa)
        score_image score_image score_image   0.999
CXCR1
chemokine (C-X-C motif) receptor 1 (350 aa)
        score_image score_image score_image   0.996
CCL5
chemokine (C-C motif) ligand 5; Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. Binds to CCR1, CCR3, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T- cells. Recombinant RANTES protein induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form RANTES(3-68) acts as a natural chemotaxis inhibitor and is a more potent inhibitor of HIV-1-infection. The second processed form RANTES(4-68) exh [...] (91 aa)
          score_image score_image   0.971
CXCL10
chemokine (C-X-C motif) ligand 10; Chemotactic for monocytes and T-lymphocytes. Binds to CXCR3 (98 aa)
          score_image score_image   0.971
CXCL11
chemokine (C-X-C motif) ligand 11; Chemotactic for interleukin-activated T-cells but not unstimulated T-cells, neutrophils or monocytes. Induces calcium release in activated T-cells. Binds to CXCR3. May play an important role in CNS diseases which involve T-cell recruitment. May play a role in skin immune responses (94 aa)
          score_image score_image   0.967
CCL20
chemokine (C-C motif) ligand 20; Chemotactic factor that attracts lymphocytes and, slightly, neutrophils, but not monocytes. Inhibits proliferation of myeloid progenitors in colony formation assays. May be involved in formation and function of the mucosal lymphoid tissues by attracting lymphocytes and dendritic cells towards epithelial cells. C-terminal processed forms have been shown to be equally chemotactically active for leukocytes. Possesses antibacterial activity E.coli ATCC 25922 and S.aureus ATCC 29213 (96 aa)
      score_image   score_image score_image   0.963
CXCL12
chemokine (C-X-C motif) ligand 12 (140 aa)
          score_image score_image   0.957
CXCR3
chemokine (C-X-C motif) receptor 3; Receptor for CXCL9, CXCL10 and CXCL11 and mediates the proliferation of human mesangial cells (HMC) (415 aa)
          score_image score_image   0.956
CCR1
chemokine (C-C motif) receptor 1; Receptor for a C-C type chemokine. Binds to MIP-1-alpha, MIP-1-delta, RANTES, and MCP-3 and, less efficiently, to MIP-1- beta or MCP-1 and subsequently transduces a signal by increasing the intracellular calcium ions level. Responsible for affecting stem cell proliferation (355 aa)
          score_image score_image   0.954
CCR5
chemokine (C-C motif) receptor 5 (gene/pseudogene) (352 aa)
          score_image score_image   0.948
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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