node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ECD | ZNF287 | ENSP00000401566 | ENSP00000379168 | ecdysoneless homolog (Drosophila); Novel regulator of p53 stability and function. May also be a transcriptional activator required for the expression of glycolytic genes | zinc finger protein 287; May be involved in transcriptional regulation | 0.577 |
ECH1 | HEATR4 | ENSP00000221418 | ENSP00000335447 | enoyl CoA hydratase 1, peroxisomal; Isomerization of 3-trans,5-cis-dienoyl-CoA to 2-trans,4- trans-dienoyl-CoA (By similarity) | HEAT repeat containing 4 | 0.557 |
ECH1 | ZNF287 | ENSP00000221418 | ENSP00000379168 | enoyl CoA hydratase 1, peroxisomal; Isomerization of 3-trans,5-cis-dienoyl-CoA to 2-trans,4- trans-dienoyl-CoA (By similarity) | zinc finger protein 287; May be involved in transcriptional regulation | 0.483 |
ECH1 | ZNF512 | ENSP00000221418 | ENSP00000347648 | enoyl CoA hydratase 1, peroxisomal; Isomerization of 3-trans,5-cis-dienoyl-CoA to 2-trans,4- trans-dienoyl-CoA (By similarity) | zinc finger protein 512; May be involved in transcriptional regulation | 0.538 |
FBXL19 | ZNF287 | ENSP00000369666 | ENSP00000379168 | F-box and leucine-rich repeat protein 19; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex (By similarity) | zinc finger protein 287; May be involved in transcriptional regulation | 0.501 |
FBXL19 | ZNF512 | ENSP00000369666 | ENSP00000347648 | F-box and leucine-rich repeat protein 19; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex (By similarity) | zinc finger protein 512; May be involved in transcriptional regulation | 0.501 |
HEATR4 | ECH1 | ENSP00000335447 | ENSP00000221418 | HEAT repeat containing 4 | enoyl CoA hydratase 1, peroxisomal; Isomerization of 3-trans,5-cis-dienoyl-CoA to 2-trans,4- trans-dienoyl-CoA (By similarity) | 0.557 |
HEATR4 | ZNF287 | ENSP00000335447 | ENSP00000379168 | HEAT repeat containing 4 | zinc finger protein 287; May be involved in transcriptional regulation | 0.483 |
HEATR4 | ZNF512 | ENSP00000335447 | ENSP00000347648 | HEAT repeat containing 4 | zinc finger protein 512; May be involved in transcriptional regulation | 0.685 |
KDM2A | ZNF287 | ENSP00000432786 | ENSP00000379168 | lysine (K)-specific demethylase 2A; Histone demethylase that specifically demethylates ’Lys- 36’ of histone H3, thereby playing a central role in histone code. Preferentially demethylates dimethylated H3 ’Lys-36’ residue while it has weak or no activity for mono- and tri-methylated H3 ’Lys- 36’. May also recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation. Required to maintain the heterochromatic state. Associates with centromeres and represses transcription of small non-coding RNAs that are encoded by the clusters of satellite repeats at [...] | zinc finger protein 287; May be involved in transcriptional regulation | 0.501 |
KDM2A | ZNF512 | ENSP00000432786 | ENSP00000347648 | lysine (K)-specific demethylase 2A; Histone demethylase that specifically demethylates ’Lys- 36’ of histone H3, thereby playing a central role in histone code. Preferentially demethylates dimethylated H3 ’Lys-36’ residue while it has weak or no activity for mono- and tri-methylated H3 ’Lys- 36’. May also recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation. Required to maintain the heterochromatic state. Associates with centromeres and represses transcription of small non-coding RNAs that are encoded by the clusters of satellite repeats at [...] | zinc finger protein 512; May be involved in transcriptional regulation | 0.501 |
KDM2B | ZNF287 | ENSP00000366271 | ENSP00000379168 | lysine (K)-specific demethylase 2B; Histone demethylase that demethylates ’Lys-4’ and ’Lys- 36’ of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 ’Lys-4’ and dimethylated H3 ’Lys-36’ residue while it has weak or no activity for mono- and tri-methylated H3 ’Lys-36’. Preferentially binds the transcribed region of ribosomal RNA and represses the transcription of ribosomal RNA genes which inhibits cell growth and proliferation. May also serve as a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin [...] | zinc finger protein 287; May be involved in transcriptional regulation | 0.501 |
KDM2B | ZNF512 | ENSP00000366271 | ENSP00000347648 | lysine (K)-specific demethylase 2B; Histone demethylase that demethylates ’Lys-4’ and ’Lys- 36’ of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 ’Lys-4’ and dimethylated H3 ’Lys-36’ residue while it has weak or no activity for mono- and tri-methylated H3 ’Lys-36’. Preferentially binds the transcribed region of ribosomal RNA and represses the transcription of ribosomal RNA genes which inhibits cell growth and proliferation. May also serve as a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin [...] | zinc finger protein 512; May be involved in transcriptional regulation | 0.501 |
SUSD1 | TMEM245 | ENSP00000363388 | ENSP00000363714 | sushi domain containing 1 | transmembrane protein 245 | 0.597 |
SUSD1 | ZNF287 | ENSP00000363388 | ENSP00000379168 | sushi domain containing 1 | zinc finger protein 287; May be involved in transcriptional regulation | 0.485 |
TMEM245 | SUSD1 | ENSP00000363714 | ENSP00000363388 | transmembrane protein 245 | sushi domain containing 1 | 0.597 |
TMEM245 | ZNF287 | ENSP00000363714 | ENSP00000379168 | transmembrane protein 245 | zinc finger protein 287; May be involved in transcriptional regulation | 0.548 |
XRN1 | ZNF287 | ENSP00000264951 | ENSP00000379168 | 5’-3’ exoribonuclease 1; Major 5’-3’ exoribonuclease involved in mRNA decay. Required for the 5’-3’-processing of the G4 tetraplex-containing DNA and RNA substrates. The kinetic of hydrolysis is faster for G4 RNA tetraplex than for G4 DNA tetraplex and monomeric RNA tetraplex. Binds to RNA and DNA (By similarity). Plays a role in replication-dependent histone mRNA degradation. May act as a tumor suppressor protein in osteogenic sarcoma (OGS) | zinc finger protein 287; May be involved in transcriptional regulation | 0.543 |
XRN1 | ZNF512 | ENSP00000264951 | ENSP00000347648 | 5’-3’ exoribonuclease 1; Major 5’-3’ exoribonuclease involved in mRNA decay. Required for the 5’-3’-processing of the G4 tetraplex-containing DNA and RNA substrates. The kinetic of hydrolysis is faster for G4 RNA tetraplex than for G4 DNA tetraplex and monomeric RNA tetraplex. Binds to RNA and DNA (By similarity). Plays a role in replication-dependent histone mRNA degradation. May act as a tumor suppressor protein in osteogenic sarcoma (OGS) | zinc finger protein 512; May be involved in transcriptional regulation | 0.543 |
ZNF287 | ECD | ENSP00000379168 | ENSP00000401566 | zinc finger protein 287; May be involved in transcriptional regulation | ecdysoneless homolog (Drosophila); Novel regulator of p53 stability and function. May also be a transcriptional activator required for the expression of glycolytic genes | 0.577 |