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SLC13A4 SLC13A4 SLC16A5 SLC16A5 SLC16A7 SLC16A7 ACACA ACACA SLC5A12 SLC5A12 ACLY ACLY PRODH2 PRODH2 CEBPD CEBPD PRODH PRODH SLC22A12 SLC22A12 SLC16A9 SLC16A9
"SLC5A12" - solute carrier family 5 (sodium/glucose cotransporter), member 12 in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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protein of unknown 3D structure
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some 3D structure is known or predicted
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query proteins and first shell of interactors
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white nodes:
second shell of interactors
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Known Interactions
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from curated databases
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experimentally determined
Predicted Interactions
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fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
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textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
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Score
SLC5A12solute carrier family 5 (sodium/glucose cotransporter), member 12; Acts as an electroneutral and low-affinity sodium (Na(+))-dependent sodium-coupled solute transporter. Catalyzes the transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, nicotinate, propionate, butyrate and beta-D- hydroxybutyrate. May be responsible for the first step of reabsorption of monocarboxylates from the lumen of the proximal tubule of the kidney and the small intestine. May play also a role in monocarboxylates transport in the retina (By similarity). Mediates electroneutral [...] (618 aa)    
Predicted Functional Partners:
SLC22A12
solute carrier family 22 (organic anion/urate transporter), member 12; Required for efficient urate re-absorption in the kidney. Regulates blood urate levels. Mediates saturable urate uptake by facilitating the exchange of urate against organic anions (553 aa)
            score_image   0.864
PRODH
proline dehydrogenase (oxidase) 1 (600 aa)
score_image     score_image     score_image   0.836
PRODH2
proline dehydrogenase (oxidase) 2; Converts proline to delta-1-pyrroline-5-carboxylate (Probable) (536 aa)
score_image     score_image     score_image   0.836
CEBPD
CCAAT/enhancer binding protein (C/EBP), delta; C/EBP is a DNA-binding protein that recognizes two different motifs- the CCAAT homology common to many promoters and the enhanced core homology common to many enhancers. Important transcriptional activator in the regulation of genes involved in immune and inflammatory responses, may play an important role in the regulation of the several genes associated with activation and/or differentiation of macrophages (269 aa)
            score_image   0.752
SLC13A4
solute carrier family 13 (sodium/sulfate symporters), member 4; Sodium/sulfate cotransporter that mediates sulfate reabsorption in the high endothelial venules (HEV) (626 aa)
            score_image   0.619
SLC16A5
solute carrier family 16, member 5 (monocarboxylic acid transporter 6); Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (By similarity) (505 aa)
            score_image   0.616
ACLY
ATP citrate lyase; ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine (1101 aa)
      score_image     score_image   0.582
SLC16A9
solute carrier family 16, member 9 (monocarboxylic acid transporter 9); Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates (By similarity) (509 aa)
            score_image   0.549
SLC16A7
solute carrier family 16, member 7 (monocarboxylic acid transporter 2); Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate. MCT2 is a high affinity pyruvate transporter (478 aa)
            score_image   0.534
ACACA
acetyl-CoA carboxylase alpha (2383 aa)
      score_image     score_image   0.529
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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