| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CDC42EP3 | ZNF35 | ENSP00000295324 | ENSP00000379368 | CDC42 effector protein (Rho GTPase binding) 3; Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation in fibroblasts | zinc finger protein 35; May be involved in transcriptional regulation. Involved in cell differentiation and/or proliferation | 0.501 |
| FAM105A | ZNF35 | ENSP00000274217 | ENSP00000379368 | family with sequence similarity 105, member A | zinc finger protein 35; May be involved in transcriptional regulation. Involved in cell differentiation and/or proliferation | 0.507 |
| FBXL19 | ZNF35 | ENSP00000369666 | ENSP00000379368 | F-box and leucine-rich repeat protein 19; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex (By similarity) | zinc finger protein 35; May be involved in transcriptional regulation. Involved in cell differentiation and/or proliferation | 0.501 |
| HAP1 | ZNF35 | ENSP00000334002 | ENSP00000379368 | huntingtin-associated protein 1; Associates specifically with huntingtin. This binding is enhanced by an expanded polyglutamine repeat | zinc finger protein 35; May be involved in transcriptional regulation. Involved in cell differentiation and/or proliferation | 0.500 |
| KDM2A | ZNF35 | ENSP00000432786 | ENSP00000379368 | lysine (K)-specific demethylase 2A; Histone demethylase that specifically demethylates ’Lys- 36’ of histone H3, thereby playing a central role in histone code. Preferentially demethylates dimethylated H3 ’Lys-36’ residue while it has weak or no activity for mono- and tri-methylated H3 ’Lys- 36’. May also recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation. Required to maintain the heterochromatic state. Associates with centromeres and represses transcription of small non-coding RNAs that are encoded by the clusters of satellite repeats at [...] | zinc finger protein 35; May be involved in transcriptional regulation. Involved in cell differentiation and/or proliferation | 0.501 |
| KDM2B | ZNF35 | ENSP00000366271 | ENSP00000379368 | lysine (K)-specific demethylase 2B; Histone demethylase that demethylates ’Lys-4’ and ’Lys- 36’ of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 ’Lys-4’ and dimethylated H3 ’Lys-36’ residue while it has weak or no activity for mono- and tri-methylated H3 ’Lys-36’. Preferentially binds the transcribed region of ribosomal RNA and represses the transcription of ribosomal RNA genes which inhibits cell growth and proliferation. May also serve as a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin [...] | zinc finger protein 35; May be involved in transcriptional regulation. Involved in cell differentiation and/or proliferation | 0.501 |
| MAPK14 | PTPN23 | ENSP00000229794 | ENSP00000265562 | mitogen-activated protein kinase 14; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK14 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases which are a [...] | protein tyrosine phosphatase, non-receptor type 23; May act as a negative regulator of Ras-mediated mitogenic activity. Plays a role in ciliogenesis | 0.784 |
| MAPK14 | ZNF35 | ENSP00000229794 | ENSP00000379368 | mitogen-activated protein kinase 14; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK14 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases which are a [...] | zinc finger protein 35; May be involved in transcriptional regulation. Involved in cell differentiation and/or proliferation | 0.517 |
| PHB | ZNF35 | ENSP00000300408 | ENSP00000379368 | prohibitin; Prohibitin inhibits DNA synthesis. It has a role in regulating proliferation. As yet it is unclear if the protein or the mRNA exhibits this effect. May play a role in regulating mitochondrial respiration activity and in aging | zinc finger protein 35; May be involved in transcriptional regulation. Involved in cell differentiation and/or proliferation | 0.500 |
| PTPN23 | MAPK14 | ENSP00000265562 | ENSP00000229794 | protein tyrosine phosphatase, non-receptor type 23; May act as a negative regulator of Ras-mediated mitogenic activity. Plays a role in ciliogenesis | mitogen-activated protein kinase 14; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK14 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases which are a [...] | 0.784 |
| PTPN23 | ZNF35 | ENSP00000265562 | ENSP00000379368 | protein tyrosine phosphatase, non-receptor type 23; May act as a negative regulator of Ras-mediated mitogenic activity. Plays a role in ciliogenesis | zinc finger protein 35; May be involved in transcriptional regulation. Involved in cell differentiation and/or proliferation | 0.476 |
| XRN1 | ZNF35 | ENSP00000264951 | ENSP00000379368 | 5’-3’ exoribonuclease 1; Major 5’-3’ exoribonuclease involved in mRNA decay. Required for the 5’-3’-processing of the G4 tetraplex-containing DNA and RNA substrates. The kinetic of hydrolysis is faster for G4 RNA tetraplex than for G4 DNA tetraplex and monomeric RNA tetraplex. Binds to RNA and DNA (By similarity). Plays a role in replication-dependent histone mRNA degradation. May act as a tumor suppressor protein in osteogenic sarcoma (OGS) | zinc finger protein 35; May be involved in transcriptional regulation. Involved in cell differentiation and/or proliferation | 0.543 |
| ZNF35 | CDC42EP3 | ENSP00000379368 | ENSP00000295324 | zinc finger protein 35; May be involved in transcriptional regulation. Involved in cell differentiation and/or proliferation | CDC42 effector protein (Rho GTPase binding) 3; Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation in fibroblasts | 0.501 |
| ZNF35 | FAM105A | ENSP00000379368 | ENSP00000274217 | zinc finger protein 35; May be involved in transcriptional regulation. Involved in cell differentiation and/or proliferation | family with sequence similarity 105, member A | 0.507 |
| ZNF35 | FBXL19 | ENSP00000379368 | ENSP00000369666 | zinc finger protein 35; May be involved in transcriptional regulation. Involved in cell differentiation and/or proliferation | F-box and leucine-rich repeat protein 19; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex (By similarity) | 0.501 |
| ZNF35 | HAP1 | ENSP00000379368 | ENSP00000334002 | zinc finger protein 35; May be involved in transcriptional regulation. Involved in cell differentiation and/or proliferation | huntingtin-associated protein 1; Associates specifically with huntingtin. This binding is enhanced by an expanded polyglutamine repeat | 0.500 |
| ZNF35 | KDM2A | ENSP00000379368 | ENSP00000432786 | zinc finger protein 35; May be involved in transcriptional regulation. Involved in cell differentiation and/or proliferation | lysine (K)-specific demethylase 2A; Histone demethylase that specifically demethylates ’Lys- 36’ of histone H3, thereby playing a central role in histone code. Preferentially demethylates dimethylated H3 ’Lys-36’ residue while it has weak or no activity for mono- and tri-methylated H3 ’Lys- 36’. May also recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation. Required to maintain the heterochromatic state. Associates with centromeres and represses transcription of small non-coding RNAs that are encoded by the clusters of satellite repeats at [...] | 0.501 |
| ZNF35 | KDM2B | ENSP00000379368 | ENSP00000366271 | zinc finger protein 35; May be involved in transcriptional regulation. Involved in cell differentiation and/or proliferation | lysine (K)-specific demethylase 2B; Histone demethylase that demethylates ’Lys-4’ and ’Lys- 36’ of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 ’Lys-4’ and dimethylated H3 ’Lys-36’ residue while it has weak or no activity for mono- and tri-methylated H3 ’Lys-36’. Preferentially binds the transcribed region of ribosomal RNA and represses the transcription of ribosomal RNA genes which inhibits cell growth and proliferation. May also serve as a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin [...] | 0.501 |
| ZNF35 | MAPK14 | ENSP00000379368 | ENSP00000229794 | zinc finger protein 35; May be involved in transcriptional regulation. Involved in cell differentiation and/or proliferation | mitogen-activated protein kinase 14; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK14 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases which are a [...] | 0.517 |
| ZNF35 | PHB | ENSP00000379368 | ENSP00000300408 | zinc finger protein 35; May be involved in transcriptional regulation. Involved in cell differentiation and/or proliferation | prohibitin; Prohibitin inhibits DNA synthesis. It has a role in regulating proliferation. As yet it is unclear if the protein or the mRNA exhibits this effect. May play a role in regulating mitochondrial respiration activity and in aging | 0.500 |
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