ENAM protein (Homo sapiens) - STRING network view

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ENAM

enamelin; Involved in the mineralization and structural organization of enamel. Involved in the extension of enamel during the secretory stage of dental enamel formation (1142 aa)

Predicted Functional Partners:

AMBN

0.901

AMELX

0.861

AMTN

0.860

MMP20

0.811

TUFT1

0.757

MARCO

0.728

PARL

0.700

BMP3

0.685

ENG

0.659

KLK4

0.634

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AMBN	AMELX	ENSP00000313809	ENSP00000370088	ameloblastin (enamel matrix protein); Involved in the mineralization and structural organization of enamel	amelogenin, X-linked; Plays a role in biomineralization. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel	0.811
AMBN	AMTN	ENSP00000313809	ENSP00000341013	ameloblastin (enamel matrix protein); Involved in the mineralization and structural organization of enamel	amelotin; Could be a cell adhesion protein involved in the maturation of tooth enamel	0.860
AMBN	BMP3	ENSP00000313809	ENSP00000282701	ameloblastin (enamel matrix protein); Involved in the mineralization and structural organization of enamel	bone morphogenetic protein 3; Negatively regulates bone density. Antagonizes the ability of certain osteogenic BMPs to induce osteoprogenitor differentitation and ossification	0.743
AMBN	ENAM	ENSP00000313809	ENSP00000379383	ameloblastin (enamel matrix protein); Involved in the mineralization and structural organization of enamel	enamelin; Involved in the mineralization and structural organization of enamel. Involved in the extension of enamel during the secretory stage of dental enamel formation	0.901
AMBN	KLK4	ENSP00000313809	ENSP00000326159	ameloblastin (enamel matrix protein); Involved in the mineralization and structural organization of enamel	kallikrein-related peptidase 4; Involved in enamel formation	0.700
AMBN	MMP20	ENSP00000313809	ENSP00000260228	ameloblastin (enamel matrix protein); Involved in the mineralization and structural organization of enamel	matrix metallopeptidase 20; Degrades amelogenin, the major protein component of the enamel matrix and two of the macromolecules characterizing the cartilage extracellular matrix- aggrecan and the cartilage oligomeric matrix protein (COMP). May play a central role in tooth enamel formation	0.870
AMBN	TUFT1	ENSP00000313809	ENSP00000357842	ameloblastin (enamel matrix protein); Involved in the mineralization and structural organization of enamel	tuftelin 1; Involved in the mineralization and structural organization of enamel	0.759
AMELX	AMBN	ENSP00000370088	ENSP00000313809	amelogenin, X-linked; Plays a role in biomineralization. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel	ameloblastin (enamel matrix protein); Involved in the mineralization and structural organization of enamel	0.811
AMELX	AMTN	ENSP00000370088	ENSP00000341013	amelogenin, X-linked; Plays a role in biomineralization. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel	amelotin; Could be a cell adhesion protein involved in the maturation of tooth enamel	0.758
AMELX	ENAM	ENSP00000370088	ENSP00000379383	amelogenin, X-linked; Plays a role in biomineralization. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel	enamelin; Involved in the mineralization and structural organization of enamel. Involved in the extension of enamel during the secretory stage of dental enamel formation	0.861
AMELX	KLK4	ENSP00000370088	ENSP00000326159	amelogenin, X-linked; Plays a role in biomineralization. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel	kallikrein-related peptidase 4; Involved in enamel formation	0.567
AMELX	MMP20	ENSP00000370088	ENSP00000260228	amelogenin, X-linked; Plays a role in biomineralization. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel	matrix metallopeptidase 20; Degrades amelogenin, the major protein component of the enamel matrix and two of the macromolecules characterizing the cartilage extracellular matrix- aggrecan and the cartilage oligomeric matrix protein (COMP). May play a central role in tooth enamel formation	0.724
AMELX	TUFT1	ENSP00000370088	ENSP00000357842	amelogenin, X-linked; Plays a role in biomineralization. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel	tuftelin 1; Involved in the mineralization and structural organization of enamel	0.747
AMTN	AMBN	ENSP00000341013	ENSP00000313809	amelotin; Could be a cell adhesion protein involved in the maturation of tooth enamel	ameloblastin (enamel matrix protein); Involved in the mineralization and structural organization of enamel	0.860
AMTN	AMELX	ENSP00000341013	ENSP00000370088	amelotin; Could be a cell adhesion protein involved in the maturation of tooth enamel	amelogenin, X-linked; Plays a role in biomineralization. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel	0.758
AMTN	ENAM	ENSP00000341013	ENSP00000379383	amelotin; Could be a cell adhesion protein involved in the maturation of tooth enamel	enamelin; Involved in the mineralization and structural organization of enamel. Involved in the extension of enamel during the secretory stage of dental enamel formation	0.860
AMTN	KLK4	ENSP00000341013	ENSP00000326159	amelotin; Could be a cell adhesion protein involved in the maturation of tooth enamel	kallikrein-related peptidase 4; Involved in enamel formation	0.532
AMTN	MMP20	ENSP00000341013	ENSP00000260228	amelotin; Could be a cell adhesion protein involved in the maturation of tooth enamel	matrix metallopeptidase 20; Degrades amelogenin, the major protein component of the enamel matrix and two of the macromolecules characterizing the cartilage extracellular matrix- aggrecan and the cartilage oligomeric matrix protein (COMP). May play a central role in tooth enamel formation	0.659
BMP3	AMBN	ENSP00000282701	ENSP00000313809	bone morphogenetic protein 3; Negatively regulates bone density. Antagonizes the ability of certain osteogenic BMPs to induce osteoprogenitor differentitation and ossification	ameloblastin (enamel matrix protein); Involved in the mineralization and structural organization of enamel	0.743
BMP3	ENAM	ENSP00000282701	ENSP00000379383	bone morphogenetic protein 3; Negatively regulates bone density. Antagonizes the ability of certain osteogenic BMPs to induce osteoprogenitor differentitation and ossification	enamelin; Involved in the mineralization and structural organization of enamel. Involved in the extension of enamel during the secretory stage of dental enamel formation	0.685

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