| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CNGB3 | PDP1 | ENSP00000316605 | ENSP00000379503 | cyclic nucleotide gated channel beta 3; Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cGMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors. Induced a flickering channel gating, weakened the outward rectification in the presence of extracellular calcium, increased sensitivity for L-cis diltiazem and enhanced the cAMP efficiency of the channel when coexpressed with CNGA3 (By similarity). Essential for the generation of light-evoked electrical [...] | pyruvate dehyrogenase phosphatase catalytic subunit 1; Catalyzes the dephosphorylation and concomitant reactivation of the alpha subunit of the E1 component of the pyruvate dehydrogenase complex (By similarity) | 0.751 |
| PDHA1 | PDP1 | ENSP00000369134 | ENSP00000379503 | pyruvate dehydrogenase (lipoamide) alpha 1 | pyruvate dehyrogenase phosphatase catalytic subunit 1; Catalyzes the dephosphorylation and concomitant reactivation of the alpha subunit of the E1 component of the pyruvate dehydrogenase complex (By similarity) | 0.848 |
| PDP1 | CNGB3 | ENSP00000379503 | ENSP00000316605 | pyruvate dehyrogenase phosphatase catalytic subunit 1; Catalyzes the dephosphorylation and concomitant reactivation of the alpha subunit of the E1 component of the pyruvate dehydrogenase complex (By similarity) | cyclic nucleotide gated channel beta 3; Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cGMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors. Induced a flickering channel gating, weakened the outward rectification in the presence of extracellular calcium, increased sensitivity for L-cis diltiazem and enhanced the cAMP efficiency of the channel when coexpressed with CNGA3 (By similarity). Essential for the generation of light-evoked electrical [...] | 0.751 |
| PDP1 | PDHA1 | ENSP00000379503 | ENSP00000369134 | pyruvate dehyrogenase phosphatase catalytic subunit 1; Catalyzes the dephosphorylation and concomitant reactivation of the alpha subunit of the E1 component of the pyruvate dehydrogenase complex (By similarity) | pyruvate dehydrogenase (lipoamide) alpha 1 | 0.848 |
| PDP1 | PIM1 | ENSP00000379503 | ENSP00000362608 | pyruvate dehyrogenase phosphatase catalytic subunit 1; Catalyzes the dephosphorylation and concomitant reactivation of the alpha subunit of the E1 component of the pyruvate dehydrogenase complex (By similarity) | pim-1 oncogene; Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation and thus providing a selective advantage in tumorigenesis. Exerts its oncogenic activity through- the regulation of MYC transcriptional activity, the regulation of cell cycle progression and by phosphorylation and inhibition of proapoptotic proteins (BAD, MAP3K5, FOXO3). Phosphorylation of MYC leads to an increase of MYC protein stability and thereby an increase of transcriptional activity. The stabilization of MYC exerted by PIM1 might explain partly the strong synergi [...] | 0.655 |
| PDP1 | PIM2 | ENSP00000379503 | ENSP00000365692 | pyruvate dehyrogenase phosphatase catalytic subunit 1; Catalyzes the dephosphorylation and concomitant reactivation of the alpha subunit of the E1 component of the pyruvate dehydrogenase complex (By similarity) | pim-2 oncogene; Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Exerts its oncogenic activity through- the regulation of MYC transcriptional activity, the regulation of cell cycle progression, the regulation of cap-dependent protein translation and through survival signaling by phosphorylation of a pro-apoptotic protein, BAD. Phosphorylation of MYC leads to an increase of MYC protein stability and thereby an increase transcriptional activity. The stabilization of MYC exerted by PIM2 might explain partly the strong synergism between [...] | 0.655 |
| PDP1 | PPTC7 | ENSP00000379503 | ENSP00000346255 | pyruvate dehyrogenase phosphatase catalytic subunit 1; Catalyzes the dephosphorylation and concomitant reactivation of the alpha subunit of the E1 component of the pyruvate dehydrogenase complex (By similarity) | PTC7 protein phosphatase homolog (S. cerevisiae) | 0.708 |
| PDP1 | RIPK4 | ENSP00000379503 | ENSP00000332454 | pyruvate dehyrogenase phosphatase catalytic subunit 1; Catalyzes the dephosphorylation and concomitant reactivation of the alpha subunit of the E1 component of the pyruvate dehydrogenase complex (By similarity) | receptor-interacting serine-threonine kinase 4; Involved in stratified epithelial development. It is a direct transcriptional target of TP63. Plays a role in NF-kappa-B activation | 0.768 |
| PDP1 | STK40 | ENSP00000379503 | ENSP00000362221 | pyruvate dehyrogenase phosphatase catalytic subunit 1; Catalyzes the dephosphorylation and concomitant reactivation of the alpha subunit of the E1 component of the pyruvate dehydrogenase complex (By similarity) | serine/threonine kinase 40 | 0.655 |
| PDP1 | TSSK1B | ENSP00000379503 | ENSP00000375081 | pyruvate dehyrogenase phosphatase catalytic subunit 1; Catalyzes the dephosphorylation and concomitant reactivation of the alpha subunit of the E1 component of the pyruvate dehydrogenase complex (By similarity) | testis-specific serine kinase 1B; Testis-specific serine/threonine-protein kinase required during spermatid development. Phosphorylates ’Ser-288’ of TSKS. Involved in the late stages of spermatogenesis, during the reconstruction of the cytoplasm. During spermatogenesis, required for the transformation of a ring-shaped structure around the base of the flagellum originating from the chromatoid body | 0.655 |
| PDP1 | TSSK2 | ENSP00000379503 | ENSP00000382544 | pyruvate dehyrogenase phosphatase catalytic subunit 1; Catalyzes the dephosphorylation and concomitant reactivation of the alpha subunit of the E1 component of the pyruvate dehydrogenase complex (By similarity) | testis-specific serine kinase 2; Testis-specific serine/threonine-protein kinase required during spermatid development. Phosphorylates TSKS at ’Ser-288’ and SPAG16. Involved in the late stages of spermatogenesis, during the reconstruction of the cytoplasm. During spermatogenesis, required for the transformation of a ring-shaped structure around the base of the flagellum originating from the chromatoid body | 0.655 |
| PDP1 | TSSK3 | ENSP00000379503 | ENSP00000362634 | pyruvate dehyrogenase phosphatase catalytic subunit 1; Catalyzes the dephosphorylation and concomitant reactivation of the alpha subunit of the E1 component of the pyruvate dehydrogenase complex (By similarity) | testis-specific serine kinase 3; May be involved in a signaling pathway during male germ cell development or mature sperm function | 0.655 |
| PIM1 | PDP1 | ENSP00000362608 | ENSP00000379503 | pim-1 oncogene; Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation and thus providing a selective advantage in tumorigenesis. Exerts its oncogenic activity through- the regulation of MYC transcriptional activity, the regulation of cell cycle progression and by phosphorylation and inhibition of proapoptotic proteins (BAD, MAP3K5, FOXO3). Phosphorylation of MYC leads to an increase of MYC protein stability and thereby an increase of transcriptional activity. The stabilization of MYC exerted by PIM1 might explain partly the strong synergi [...] | pyruvate dehyrogenase phosphatase catalytic subunit 1; Catalyzes the dephosphorylation and concomitant reactivation of the alpha subunit of the E1 component of the pyruvate dehydrogenase complex (By similarity) | 0.655 |
| PIM1 | PPTC7 | ENSP00000362608 | ENSP00000346255 | pim-1 oncogene; Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation and thus providing a selective advantage in tumorigenesis. Exerts its oncogenic activity through- the regulation of MYC transcriptional activity, the regulation of cell cycle progression and by phosphorylation and inhibition of proapoptotic proteins (BAD, MAP3K5, FOXO3). Phosphorylation of MYC leads to an increase of MYC protein stability and thereby an increase of transcriptional activity. The stabilization of MYC exerted by PIM1 might explain partly the strong synergi [...] | PTC7 protein phosphatase homolog (S. cerevisiae) | 0.643 |
| PIM2 | PDP1 | ENSP00000365692 | ENSP00000379503 | pim-2 oncogene; Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Exerts its oncogenic activity through- the regulation of MYC transcriptional activity, the regulation of cell cycle progression, the regulation of cap-dependent protein translation and through survival signaling by phosphorylation of a pro-apoptotic protein, BAD. Phosphorylation of MYC leads to an increase of MYC protein stability and thereby an increase transcriptional activity. The stabilization of MYC exerted by PIM2 might explain partly the strong synergism between [...] | pyruvate dehyrogenase phosphatase catalytic subunit 1; Catalyzes the dephosphorylation and concomitant reactivation of the alpha subunit of the E1 component of the pyruvate dehydrogenase complex (By similarity) | 0.655 |
| PIM2 | PPTC7 | ENSP00000365692 | ENSP00000346255 | pim-2 oncogene; Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Exerts its oncogenic activity through- the regulation of MYC transcriptional activity, the regulation of cell cycle progression, the regulation of cap-dependent protein translation and through survival signaling by phosphorylation of a pro-apoptotic protein, BAD. Phosphorylation of MYC leads to an increase of MYC protein stability and thereby an increase transcriptional activity. The stabilization of MYC exerted by PIM2 might explain partly the strong synergism between [...] | PTC7 protein phosphatase homolog (S. cerevisiae) | 0.643 |
| PPTC7 | PDP1 | ENSP00000346255 | ENSP00000379503 | PTC7 protein phosphatase homolog (S. cerevisiae) | pyruvate dehyrogenase phosphatase catalytic subunit 1; Catalyzes the dephosphorylation and concomitant reactivation of the alpha subunit of the E1 component of the pyruvate dehydrogenase complex (By similarity) | 0.708 |
| PPTC7 | PIM1 | ENSP00000346255 | ENSP00000362608 | PTC7 protein phosphatase homolog (S. cerevisiae) | pim-1 oncogene; Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation and thus providing a selective advantage in tumorigenesis. Exerts its oncogenic activity through- the regulation of MYC transcriptional activity, the regulation of cell cycle progression and by phosphorylation and inhibition of proapoptotic proteins (BAD, MAP3K5, FOXO3). Phosphorylation of MYC leads to an increase of MYC protein stability and thereby an increase of transcriptional activity. The stabilization of MYC exerted by PIM1 might explain partly the strong synergi [...] | 0.643 |
| PPTC7 | PIM2 | ENSP00000346255 | ENSP00000365692 | PTC7 protein phosphatase homolog (S. cerevisiae) | pim-2 oncogene; Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Exerts its oncogenic activity through- the regulation of MYC transcriptional activity, the regulation of cell cycle progression, the regulation of cap-dependent protein translation and through survival signaling by phosphorylation of a pro-apoptotic protein, BAD. Phosphorylation of MYC leads to an increase of MYC protein stability and thereby an increase transcriptional activity. The stabilization of MYC exerted by PIM2 might explain partly the strong synergism between [...] | 0.643 |
| PPTC7 | RIPK4 | ENSP00000346255 | ENSP00000332454 | PTC7 protein phosphatase homolog (S. cerevisiae) | receptor-interacting serine-threonine kinase 4; Involved in stratified epithelial development. It is a direct transcriptional target of TP63. Plays a role in NF-kappa-B activation | 0.768 |
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