ADCYAP1R1 protein (Homo sapiens) - STRING network view

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Size

small nodes:
protein of unknown 3D structure

large nodes:
some 3D structure is known or predicted

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

ADCYAP1R1

adenylate cyclase activating polypeptide 1 (pituitary) receptor type I; This is a receptor for PACAP-27 and PACAP-38. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. May regulate the release of adrenocorticotropin, luteinizing hormone, growth hormone, prolactin, epinephrine, and catecholamine. May play a role in spermatogenesis and sperm motility. Causes smooth muscle relaxation and secretion in the gastrointestinal tract (496 aa)

Predicted Functional Partners:

ADCYAP1

0.998

VIP

0.973

GCG

0.956

NPS

0.948

GHRH

0.944

PTH

0.925

ADCY1

0.920

CRH

0.918

POMC

0.917

GIP

0.917

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but resolution at 400 dpi

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as simple tabular text output:

download

TSV: tab separated values - can be opened in Excel

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and annotated functions of the network proteins

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADCY1	ADCYAP1	ENSP00000297323	ENSP00000411658	adenylate cyclase 1 (brain); This is a calmodulin-sensitive adenylyl cyclase. May be involved in regulatory processes in the central nervous system. It may play a role in memory acquisition and learning	adenylate cyclase activating polypeptide 1 (pituitary); Binding to its receptor activates G proteins and stimulates adenylate cyclase in pituitary cells	0.914
ADCY1	ADCYAP1R1	ENSP00000297323	ENSP00000379514	adenylate cyclase 1 (brain); This is a calmodulin-sensitive adenylyl cyclase. May be involved in regulatory processes in the central nervous system. It may play a role in memory acquisition and learning	adenylate cyclase activating polypeptide 1 (pituitary) receptor type I; This is a receptor for PACAP-27 and PACAP-38. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. May regulate the release of adrenocorticotropin, luteinizing hormone, growth hormone, prolactin, epinephrine, and catecholamine. May play a role in spermatogenesis and sperm motility. Causes smooth muscle relaxation and secretion in the gastrointestinal tract	0.920
ADCY1	CRH	ENSP00000297323	ENSP00000276571	adenylate cyclase 1 (brain); This is a calmodulin-sensitive adenylyl cyclase. May be involved in regulatory processes in the central nervous system. It may play a role in memory acquisition and learning	corticotropin releasing hormone; This hormone from hypothalamus regulates the release of corticotropin from pituitary gland	0.900
ADCY1	GCG	ENSP00000297323	ENSP00000387662	adenylate cyclase 1 (brain); This is a calmodulin-sensitive adenylyl cyclase. May be involved in regulatory processes in the central nervous system. It may play a role in memory acquisition and learning	glucagon; Glicentin may modulate gastric acid secretion and the gastro-pyloro-duodenal activity. May play an important role in intestinal mucosal growth in the early period of life	0.918
ADCY1	GHRH	ENSP00000297323	ENSP00000237527	adenylate cyclase 1 (brain); This is a calmodulin-sensitive adenylyl cyclase. May be involved in regulatory processes in the central nervous system. It may play a role in memory acquisition and learning	growth hormone releasing hormone; GRF is released by the hypothalamus and acts on the adenohypophyse to stimulate the secretion of growth hormone	0.917
ADCY1	GIP	ENSP00000297323	ENSP00000350005	adenylate cyclase 1 (brain); This is a calmodulin-sensitive adenylyl cyclase. May be involved in regulatory processes in the central nervous system. It may play a role in memory acquisition and learning	gastric inhibitory polypeptide; Potent stimulator of insulin secretion and relatively poor inhibitor of gastric acid secretion	0.900
ADCY1	NPS	ENSP00000297323	ENSP00000381105	adenylate cyclase 1 (brain); This is a calmodulin-sensitive adenylyl cyclase. May be involved in regulatory processes in the central nervous system. It may play a role in memory acquisition and learning	neuropeptide S; Modulates arousal and anxiety. May play an important anorexigenic role. Binds to its receptor NPSR1 with nanomolar affinity to increase intracellular calcium concentrations (By similarity)	0.900
ADCY1	POMC	ENSP00000297323	ENSP00000264708	adenylate cyclase 1 (brain); This is a calmodulin-sensitive adenylyl cyclase. May be involved in regulatory processes in the central nervous system. It may play a role in memory acquisition and learning	proopiomelanocortin; ACTH stimulates the adrenal glands to release cortisol	0.913
ADCY1	PTH	ENSP00000297323	ENSP00000282091	adenylate cyclase 1 (brain); This is a calmodulin-sensitive adenylyl cyclase. May be involved in regulatory processes in the central nervous system. It may play a role in memory acquisition and learning	parathyroid hormone; PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion. Stimulates [1-14C]-2- deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblastic cells	0.922
ADCY1	VIP	ENSP00000297323	ENSP00000356213	adenylate cyclase 1 (brain); This is a calmodulin-sensitive adenylyl cyclase. May be involved in regulatory processes in the central nervous system. It may play a role in memory acquisition and learning	vasoactive intestinal peptide; VIP causes vasodilation, lowers arterial blood pressure, stimulates myocardial contractility, increases glycogenolysis and relaxes the smooth muscle of trachea, stomach and gall bladder	0.903
ADCYAP1	ADCY1	ENSP00000411658	ENSP00000297323	adenylate cyclase activating polypeptide 1 (pituitary); Binding to its receptor activates G proteins and stimulates adenylate cyclase in pituitary cells	adenylate cyclase 1 (brain); This is a calmodulin-sensitive adenylyl cyclase. May be involved in regulatory processes in the central nervous system. It may play a role in memory acquisition and learning	0.914
ADCYAP1	ADCYAP1R1	ENSP00000411658	ENSP00000379514	adenylate cyclase activating polypeptide 1 (pituitary); Binding to its receptor activates G proteins and stimulates adenylate cyclase in pituitary cells	adenylate cyclase activating polypeptide 1 (pituitary) receptor type I; This is a receptor for PACAP-27 and PACAP-38. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. May regulate the release of adrenocorticotropin, luteinizing hormone, growth hormone, prolactin, epinephrine, and catecholamine. May play a role in spermatogenesis and sperm motility. Causes smooth muscle relaxation and secretion in the gastrointestinal tract	0.998
ADCYAP1	CRH	ENSP00000411658	ENSP00000276571	adenylate cyclase activating polypeptide 1 (pituitary); Binding to its receptor activates G proteins and stimulates adenylate cyclase in pituitary cells	corticotropin releasing hormone; This hormone from hypothalamus regulates the release of corticotropin from pituitary gland	0.915
ADCYAP1	GCG	ENSP00000411658	ENSP00000387662	adenylate cyclase activating polypeptide 1 (pituitary); Binding to its receptor activates G proteins and stimulates adenylate cyclase in pituitary cells	glucagon; Glicentin may modulate gastric acid secretion and the gastro-pyloro-duodenal activity. May play an important role in intestinal mucosal growth in the early period of life	0.933
ADCYAP1	GHRH	ENSP00000411658	ENSP00000237527	adenylate cyclase activating polypeptide 1 (pituitary); Binding to its receptor activates G proteins and stimulates adenylate cyclase in pituitary cells	growth hormone releasing hormone; GRF is released by the hypothalamus and acts on the adenohypophyse to stimulate the secretion of growth hormone	0.964
ADCYAP1	GIP	ENSP00000411658	ENSP00000350005	adenylate cyclase activating polypeptide 1 (pituitary); Binding to its receptor activates G proteins and stimulates adenylate cyclase in pituitary cells	gastric inhibitory polypeptide; Potent stimulator of insulin secretion and relatively poor inhibitor of gastric acid secretion	0.954
ADCYAP1	NPS	ENSP00000411658	ENSP00000381105	adenylate cyclase activating polypeptide 1 (pituitary); Binding to its receptor activates G proteins and stimulates adenylate cyclase in pituitary cells	neuropeptide S; Modulates arousal and anxiety. May play an important anorexigenic role. Binds to its receptor NPSR1 with nanomolar affinity to increase intracellular calcium concentrations (By similarity)	0.935
ADCYAP1	POMC	ENSP00000411658	ENSP00000264708	adenylate cyclase activating polypeptide 1 (pituitary); Binding to its receptor activates G proteins and stimulates adenylate cyclase in pituitary cells	proopiomelanocortin; ACTH stimulates the adrenal glands to release cortisol	0.917
ADCYAP1	PTH	ENSP00000411658	ENSP00000282091	adenylate cyclase activating polypeptide 1 (pituitary); Binding to its receptor activates G proteins and stimulates adenylate cyclase in pituitary cells	parathyroid hormone; PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion. Stimulates [1-14C]-2- deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblastic cells	0.906
ADCYAP1	VIP	ENSP00000411658	ENSP00000356213	adenylate cyclase activating polypeptide 1 (pituitary); Binding to its receptor activates G proteins and stimulates adenylate cyclase in pituitary cells	vasoactive intestinal peptide; VIP causes vasodilation, lowers arterial blood pressure, stimulates myocardial contractility, increases glycogenolysis and relaxes the smooth muscle of trachea, stomach and gall bladder	0.913

page 1 of 6

Experiments

Cooccurrence

Databases

Neighborhood

Textmining

Fusion

Coexpression

© STRING Consortium 2017

Credits

Access

Info

About